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AR013375A1 - Proceso para producir enaminonas - Google Patents

Proceso para producir enaminonas

Info

Publication number
AR013375A1
AR013375A1 ARP980103737A ARP980103737A AR013375A1 AR 013375 A1 AR013375 A1 AR 013375A1 AR P980103737 A ARP980103737 A AR P980103737A AR P980103737 A ARP980103737 A AR P980103737A AR 013375 A1 AR013375 A1 AR 013375A1
Authority
AR
Argentina
Prior art keywords
chain alkyl
phenyl
cycloalkyl
group
branched chain
Prior art date
Application number
ARP980103737A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/106,471 external-priority patent/US5932745A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR013375A1 publication Critical patent/AR013375A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un proceso para producir una enaminona de la formula (I): en la cual X es seleccionado entre el grupo de H, alquilo de cadena recta C1-6, alquilo decadena ramificada C3-5, cicloalquilo C3-7, -CH2-fenilo o -CH2-fenilo sustituido;R1 es seleccionado entre el grupo que consiste en hidrogeno, alquilode cadena recta C1-6, alquilo de cadena ramificada C3-6, cicloalquilo C3-7, fenilo, fenilo sustituido, CH2-fenilo o -CH2-fenilo sustituido o un grupo delas formulas (a) donde los grupos cicloalquilo C3-7 están optativamente sustituidos con 1 a 3 grupos independientemente seleccionados entre R5-R9; R2 yR3 son independientemente seleccionados entre el grupo que consiste en alquilo de cadena recta C1-6, alquilo de cadena ramificada C3-6, cicloalquilo C3-7 oCh2-fenilo; o R2 y R3 pueden estar unidos para formar un anillo de tres a seis átomos; R4 y R4 son independientemente seleccionados entre el grupo queconsiste en hidrogeno, alquilo de cadena recta C1-6, alquilo de cadena ramificada C3-6, cicloalquilo C3-7 -OR11, -NR11R13, -NR11C(O)OR10, NR11C(O)R10,OC(O)R10, OC(O)OR10 o OC(O)NHR10. Fenilo sustituido y -CH2-fenilo sustituido son b: R5-R9 son independientemente seleccionados entre el grupo que consisteenhidrogeno, halogeno, trifluorometilo, perfluoroalquilo C2-6, alquilo de cadena recta C1-6, alquilo de cadena ramificada C3-6, cicloalquilo C3-7, -CN,-NO2, -OR11, -CO2R11, NR11R13, -NR11C(O)OR11, -NR11C(O)R11, OC(O)R11, OC(O)OR11 o OC(O)NHR11; R10 es seleccionado entre el grupo que consiste en hidrogeno,alquilo de cadena recta C1-C10, alquilo de cadena ramificada C3-10, cicloalquilo C3-7, fenilo o -CH2-fenilo; R11 y R11 son independientementeseleccionados entre el grupo que consiste en hidrogeno, alquilo de cadena recta C1-6, alquilo de cadena ramificada C3-6, cicloalquilo C3-7, fenilo, fenilo
ARP980103737A 1997-07-30 1998-07-29 Proceso para producir enaminonas AR013375A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90329997A 1997-07-30 1997-07-30
US09/106,471 US5932745A (en) 1997-07-30 1998-06-30 Process for converting propargylic amine-N-oxides to enaminones

Publications (1)

Publication Number Publication Date
AR013375A1 true AR013375A1 (es) 2000-12-27

Family

ID=26803694

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103737A AR013375A1 (es) 1997-07-30 1998-07-29 Proceso para producir enaminonas

Country Status (7)

Country Link
EP (1) EP1000012A1 (es)
JP (1) JP2001512095A (es)
AR (1) AR013375A1 (es)
AU (1) AU747543B2 (es)
CA (1) CA2298595A1 (es)
TW (1) TW513394B (es)
WO (1) WO1999006351A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235900B1 (en) * 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
JP4706320B2 (ja) * 2005-04-25 2011-06-22 宇部興産株式会社 Ｎ，ｎ−ジメチルアミノアルケノン化合物の製法
JP4706325B2 (ja) * 2005-05-10 2011-06-22 宇部興産株式会社 ４−置換−１−ｎ，ｎ−ジアルキルアミノ−１−ブテン−３−オンの取得方法
JP2014523899A (ja) * 2011-07-06 2014-09-18 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ アミノプロピンまたはエナミノンの製造方法
CN115233243A (zh) * 2022-06-27 2022-10-25 台州学院 一种电催化下2,4,5-三取代噁唑衍生物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059709A (en) * 1990-11-13 1991-10-22 American Cyanamid Company Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles

Also Published As

Publication number Publication date
CA2298595A1 (en) 1999-02-11
JP2001512095A (ja) 2001-08-21
AU8512198A (en) 1999-02-22
WO1999006351A1 (en) 1999-02-11
TW513394B (en) 2002-12-11
EP1000012A1 (en) 2000-05-17
AU747543B2 (en) 2002-05-16

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Legal Events

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