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AR011210A1 - Derivados de propanolamina, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su utilizacion - Google Patents

Derivados de propanolamina, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su utilizacion

Info

Publication number
AR011210A1
AR011210A1 ARP980101512A ARP980101512A AR011210A1 AR 011210 A1 AR011210 A1 AR 011210A1 AR P980101512 A ARP980101512 A AR P980101512A AR P980101512 A ARP980101512 A AR P980101512A AR 011210 A1 AR011210 A1 AR 011210A1
Authority
AR
Argentina
Prior art keywords
alkyl
coor11
cooh
cho
fluoro
Prior art date
Application number
ARP980101512A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998102530 external-priority patent/DE19802530A1/de
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR011210A1 publication Critical patent/AR011210A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Derivados de propanolamina de la formula (I), en la que R1 y R2 son, independientemente uno de otro, cicloalquilo con 3-8 átomos de C en el anillo,fenilo, naftilo, fenantrilo, piridilo, tienilo, furilo, pirimidilo, indolilo, tiazolilo,imida zolilo, cumarinilo, ftaliminilo, quinoilo, piperazinilo,tetrazolilo, triazolilo, oxazolilo o sus derivados condensados con tieno, piridino o benzo, pudiendo el anillo de cicloalquilo, el radical aromáticoo el radical heteroaromáticoestar susti tuidos de una a tres veces con fluoro, cloro, bromo, yodo, OH, CF3, -NO2, CN, alcoxi (C1-C8), alquilo (C1-C8), NH2,-NH-R9, -N(R9)R10, -CHO, -COOH, -COOR11, -(C=O)-R12, alquil (C1-C6)-OH, alquil (C1-C6)(OH)-fenilo, alquil (C1-C6)-CF3,alquil (C1-C6) -NO2, alquil (C1-C6)-CN,alquil (C1-C6)-NH2, alquil (C1-C6)-NH-R9, alquil (C1-C6)-N(R9)R10, alquil (C1-6)-CHO, alquil (C1-C6)-COOH, alquil (C1-C6)-COOR11, alquil (C1-C6)-(C=O)-R12, -O-alquil (C1-C6)-OH, -O-alquil (C1-C6)-CF3, -O-alquil (C1-C6)-N O2, -O- alquil (C1-C6)-CN, -O-alquil (C1-C6)-NH2, -O-alquil (C1-C6)-NH-R9, -O-alquil(C1-C6)-N(R9)R10, -O-alquil (C1-C6)-CHO, -O-alquil (C1-C6)-COOH, -O-alquil (C1-C6)-COOR11, -O-alquil (C1-C6)-(C=O)-R12, -N-SO2H, -SO2-CH3, -O-alquil(C1-C6)-O- alquil (C1-C6)-fenilo, pudiendo en los radicales alquilo uno (o varios) átomo(s) de hidrogeno estar reemplazados por fluoro; R3 hasta R6,independientemente unos de otros, son hidrogeno, fluoro, cloro, bromo, yodo, OH,CF3, -NO2, CN, alcoxi ( C1-C8), alquilo (C1-C8), NH2, -NH-R9, -N(R9)R10,-CHO, -COOH, -COOR11, -(C=O)-R12, pudiendo en los radicales alquilo uno (o varios) átomo(s) de hidrogeno estar reemplazados por fluoro; R9 hasta R12 son,independientementeunos de otros, hidrogeno, alquilo (C1-C8); X es CH, NH; Y es CH, NH; con la condicion de que los radicales R1, R2, X e Y no han de tener al
ARP980101512A 1997-04-04 1998-04-02 Derivados de propanolamina, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su utilizacion AR011210A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19713865 1997-04-04
DE1998102530 DE19802530A1 (de) 1998-01-26 1998-01-26 Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number Publication Date
AR011210A1 true AR011210A1 (es) 2000-08-02

Family

ID=26035472

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101512A AR011210A1 (es) 1997-04-04 1998-04-02 Derivados de propanolamina, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su utilizacion

Country Status (24)

Country Link
US (1) US5874451A (es)
EP (1) EP0869121B1 (es)
JP (1) JP4234805B2 (es)
KR (1) KR19980081055A (es)
CN (1) CN1185217C (es)
AR (1) AR011210A1 (es)
AT (1) ATE268758T1 (es)
AU (1) AU730228B2 (es)
BR (1) BR9801150A (es)
CA (1) CA2233925A1 (es)
CZ (1) CZ293758B6 (es)
DE (1) DE59811528D1 (es)
DK (1) DK0869121T3 (es)
ES (1) ES2223091T3 (es)
HK (1) HK1015789A1 (es)
HU (1) HUP9800781A3 (es)
ID (1) ID20137A (es)
IL (1) IL123927A (es)
MY (1) MY114944A (es)
NZ (1) NZ330110A (es)
PL (1) PL325699A1 (es)
PT (1) PT869121E (es)
RU (1) RU2198876C2 (es)
TR (1) TR199800608A3 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845402B4 (de) 1998-10-02 2005-04-07 Aventis Pharma Deutschland Gmbh Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US6489344B1 (en) 1998-06-19 2002-12-03 Chiron Corporation Inhibitors of glycogen synthase kinase 3
DE19845403B4 (de) * 1998-10-02 2005-02-10 Aventis Pharma Deutschland Gmbh Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845406C2 (de) * 1998-10-02 2001-10-18 Aventis Pharma Gmbh Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845405C2 (de) * 1998-10-02 2000-07-13 Aventis Pharma Gmbh Arylsubstituierte Propanolaminderivate und deren Verwendung
ATE338039T1 (de) * 2000-12-21 2006-09-15 Sanofi Aventis Deutschland Diphenylazetidinonderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
JP2005505538A (ja) * 2001-08-22 2005-02-24 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング アリール置換プロパノールアミン誘導体と他の活性成分との組み合わせ物およびその使用
EP2565178A1 (en) 2002-10-03 2013-03-06 Ono Pharmaceutical Co., Ltd. LPA Receptor Antagonists
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
JP4766384B2 (ja) * 2003-12-19 2011-09-07 小野薬品工業株式会社 リゾホスファチジン酸受容体拮抗作用を有する化合物およびその用途
CN1869002A (zh) * 2005-05-27 2006-11-29 中国科学院上海药物研究所 一类非甾体雄激素受体调节剂、其制备方法和用途
JP5461189B2 (ja) * 2006-11-15 2014-04-02 ワイエム・バイオサイエンスィーズ・オーストラリア・ピーティーワイ・リミテッド キナーゼ活性の阻害剤
US20110294767A1 (en) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US20140243281A1 (en) 2011-10-28 2014-08-28 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
EP2770990A4 (en) 2011-10-28 2015-03-11 Lumena Pharmaceuticals Inc Gallic acid refluxing agent for the treatment of hypertension and chronic liver disease
CN105228607A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗原发性硬化性胆管炎和炎性肠病的胆汁酸再循环抑制剂
MX2015013196A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett.
CN105553262B (zh) * 2015-08-24 2018-02-16 苏州瑞铬优电子科技有限公司 一种提高dc/dc升压变换器转换效率的方法
ES2982943T3 (es) 2019-02-12 2024-10-21 Mirum Pharmaceuticals Inc Métodos para aumentar el crecimiento en sujetos pediátricos con hepatopatía colestásica

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI892341A (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
DE59108326D1 (de) * 1990-12-06 1996-12-12 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
DK0557879T3 (da) * 1992-02-22 1997-06-16 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse

Also Published As

Publication number Publication date
HUP9800781A2 (hu) 1999-06-28
AU730228B2 (en) 2001-03-01
JP4234805B2 (ja) 2009-03-04
CN1185217C (zh) 2005-01-19
MY114944A (en) 2003-02-28
DK0869121T3 (da) 2004-09-20
RU2198876C2 (ru) 2003-02-20
ATE268758T1 (de) 2004-06-15
BR9801150A (pt) 2000-03-21
CZ293758B6 (cs) 2004-07-14
JPH10287651A (ja) 1998-10-27
PL325699A1 (en) 1998-10-12
EP0869121B1 (de) 2004-06-09
CN1199731A (zh) 1998-11-25
HUP9800781A3 (en) 1999-07-28
IL123927A (en) 2001-01-28
AU6062498A (en) 1998-10-08
CZ102598A3 (cs) 1998-10-14
PT869121E (pt) 2004-10-29
CA2233925A1 (en) 1998-10-04
DE59811528D1 (de) 2004-07-15
US5874451A (en) 1999-02-23
TR199800608A2 (en) 1998-10-21
HU9800781D0 (en) 1998-05-28
ID20137A (id) 1998-10-08
ES2223091T3 (es) 2005-02-16
NZ330110A (en) 1999-03-29
HK1015789A1 (en) 1999-10-22
EP0869121A1 (de) 1998-10-07
TR199800608A3 (tr) 1998-10-21
KR19980081055A (ko) 1998-11-25

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