AR011082A1 - Heterociclos de 5 miembros con sustitucion por bifenilsulfonilo, su uso para la preparacion de un medicamento asi como medicamento que los contiene - Google Patents
Heterociclos de 5 miembros con sustitucion por bifenilsulfonilo, su uso para la preparacion de un medicamento asi como medicamento que los contieneInfo
- Publication number
- AR011082A1 AR011082A1 ARP980100244A ARP980100244A AR011082A1 AR 011082 A1 AR011082 A1 AR 011082A1 AR P980100244 A ARP980100244 A AR P980100244A AR P980100244 A ARP980100244 A AR P980100244A AR 011082 A1 AR011082 A1 AR 011082A1
- Authority
- AR
- Argentina
- Prior art keywords
- zero
- medicinal product
- alkyl
- atoms
- independently
- Prior art date
Links
- -1 BIPHENYL SULFONYL Chemical class 0.000 title abstract 3
- 238000006467 substitution reaction Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 2
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Heterocíclicos de 5 miembros con sustitucion por bifenilsulfonilo de la formula (I), en la que los símbolos tienen los siguientes significados: R1es hidrogeno, alquilo con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C o -Ca-H2a-fenilo, que está sin sustituir o sustituido con 1-3 sustituyentes que se relacionanentre el grupo que consta de F, Cl, Br, I, CF3, metilo, metoxi, hidroxi y NR(8)R(9); R(8) y R(9), independientemente uno de otro son H o alquilo (C1-C4);a es cero, 1 o 2; o R1 es -CbH2b heteroarilo (C1-C9), que está sin sustituir o sustituido segun se describe en la memoria descriptiva; b es cero, 1 o 2; oR1 es -Cd-H2d-cicloalquilo (C3-C7); d es cero, 1 o 2; R2 y R3, independientemente uno de otro, son hidrogeno, F,Cl, Br, I, CF3, -CN, -NO2,CH2OR17, CO-R6 o O-R7; R17, R6 y R7 tienen su significado dado en la memoria descriptivia, significan H o alquilo (C1-C4); o R2 y R3 independientemente unoo de otro, son alquilo con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C, cicloalquilo con 3, 4, 5, 6 o 7 átomos de C o CgH2g-fenilo, que está sin sustituir osustituido, tienen su significado dado en la memoria descriptiva; g es cero, 1 o 2; o R2 y R3 son, independientemente uno de otro, -ClH2l-heteroarilo (C1-C9),que está sin sustituir o sustituido, tienen su significado dado en la memoria descriptiva; l es cero, 1 o 2; o R2 y R3 son, independientemente uno de otro,SOn-R22; n es cero, 1 o 2; R22 es alquilo con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C, cicloalquilocon 3, 4, 5, 6 o 7 átomos de C o -CsH2s-fenilo, que estásin sustituir o sustituido, tienen su significado dado en la memoria descriptiva; s es cero, 1 o 2; R4 y R5 independientemente uno de otro,son hidrogeno, alquilo con 1, 2, 3, 4, 5, 6, 7 u 8 átomos de C, F, Cl, Br, I, CF3, -CN, -NO2, SOp-R16, CO-R23 o R-24; p es cero, 1 o 2; R16 es alquilo con
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702045A DE19702045A1 (de) | 1997-01-22 | 1997-01-22 | Imidazol-Derivae mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19731328A DE19731328A1 (de) | 1997-07-22 | 1997-07-22 | Imidazol-Derivate mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE1997141636 DE19741636A1 (de) | 1997-09-22 | 1997-09-22 | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011082A1 true AR011082A1 (es) | 2000-08-02 |
Family
ID=27217050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100244A AR011082A1 (es) | 1997-01-22 | 1998-01-20 | Heterociclos de 5 miembros con sustitucion por bifenilsulfonilo, su uso para la preparacion de un medicamento asi como medicamento que los contiene |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6335451B1 (es) |
| EP (1) | EP0855392A3 (es) |
| JP (1) | JPH10204064A (es) |
| KR (1) | KR100529479B1 (es) |
| CN (1) | CN1176911C (es) |
| AR (1) | AR011082A1 (es) |
| AU (1) | AU738676B2 (es) |
| BR (1) | BR9800436A (es) |
| CA (1) | CA2227112A1 (es) |
| CZ (1) | CZ18598A3 (es) |
| HK (1) | HK1009814A1 (es) |
| HR (1) | HRP980025A2 (es) |
| HU (1) | HUP9800112A3 (es) |
| ID (1) | ID19574A (es) |
| IL (1) | IL123013A (es) |
| MY (1) | MY121708A (es) |
| NO (1) | NO311570B1 (es) |
| NZ (1) | NZ329606A (es) |
| PL (1) | PL191575B1 (es) |
| SK (1) | SK284126B6 (es) |
| TR (1) | TR199800084A3 (es) |
| TW (1) | TW593283B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19741635A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| AU742506B2 (en) * | 1997-10-17 | 2002-01-03 | Eurogene Limited | The use of inhibitors of the renin-angiotensin system |
| DE19802969A1 (de) | 1998-01-27 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten |
| DE19804251A1 (de) | 1998-02-04 | 1999-08-05 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19820064A1 (de) | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19832429A1 (de) | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| WO2000066161A1 (fr) * | 1999-04-28 | 2000-11-09 | Takeda Chemical Industries, Ltd. | Preventifs / remedes / inhibiteurs de progression pour retinopathie simplex ou retinopathie preproliferante |
| EP1329218A4 (en) * | 2000-10-25 | 2007-04-04 | Takeda Pharmaceutical | PREVENTIVE / REMEDY AGENTS FOR PORTAL HYPERTENSION |
| IL147696A0 (en) * | 2001-01-25 | 2002-08-14 | Pfizer Prod Inc | Combination therapy |
| US6423705B1 (en) | 2001-01-25 | 2002-07-23 | Pfizer Inc. | Combination therapy |
| AU2002257970B2 (en) * | 2001-05-31 | 2007-08-02 | Vicore Pharma Ab | Tricyclic compounds useful as angiotensin II agonists |
| MXPA04007569A (es) * | 2002-02-04 | 2004-11-01 | Aventis Pharma Gmbh | Preparacion de la combinacion del inhibidor del intercambio sodio-hidrogeno cariporida con inhibidores ace para evitar la insuficiencia cardiaca y otras disfunciones de los organos relacionadas con la edad, padecimientos relacionados con la edad y pa |
| US6844361B2 (en) | 2002-02-04 | 2005-01-18 | Aventis Pharma Deutschland Gmbh | Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor |
| US20030220383A1 (en) * | 2002-02-14 | 2003-11-27 | Aventis Pharma Deutschland Gmbh | Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders |
| ES2282062T1 (es) * | 2004-06-04 | 2007-10-16 | Teva Pharmaceutical Industries Ltd. | Composicion farmaceutica que contiene irbesartan. |
| CA2604038C (en) * | 2005-04-12 | 2013-11-12 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
| US8080571B2 (en) * | 2005-04-12 | 2011-12-20 | Vicore Pharma Ab | Tricyclic angiotensin II agonists |
| WO2006109058A1 (en) | 2005-04-12 | 2006-10-19 | Vicore Pharma Ab | New bicyclic angiotensin ii agonists |
| US10517839B2 (en) | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| JP5395905B2 (ja) | 2008-09-02 | 2014-01-22 | エルダー・ファーマシューティカルズ・リミテッド | 抗炎症化合物 |
| CN103992276B (zh) * | 2014-06-03 | 2016-08-24 | 吉林省药物研究院 | 4’-{[(2,4,5-三取代苯基)-1h-咪唑-1-基]甲基}联苯-2-甲酸衍生物 |
| CA2953064C (en) | 2014-07-17 | 2023-06-20 | University Of Southern California | Methods, compounds, and compositions for the treatment of musculoskeletal diseases |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| WO2024149712A1 (en) * | 2023-01-09 | 2024-07-18 | Vicore Pharma Ab | Selective angiotensin ii compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0819110B2 (ja) * | 1986-06-04 | 1996-02-28 | 富山化学工業株式会社 | 新規なイミダゾール誘導体もしくはその塩およびそれらを含有する抗炎症剤、解熱鎮痛剤または抗関節炎剤 |
| IL98319A (en) | 1990-07-05 | 1997-04-15 | Roussel Uclaf | Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them |
| US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
| CA2058198A1 (en) | 1991-01-04 | 1992-07-05 | Adalbert Wagner | Azole derivatives, process for their preparation, and their use |
| WO1992020662A1 (en) | 1991-05-10 | 1992-11-26 | Merck & Co., Inc. | Acidic aralkyl triazole derivatives active as angiotensin ii antagonists |
| TW215434B (es) | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
| JPH0625229A (ja) * | 1992-03-09 | 1994-02-01 | Japan Tobacco Inc | 新規なイミダゾール誘導体 |
| FR2711367B1 (fr) | 1993-10-19 | 1995-12-01 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
| FR2711368B1 (fr) | 1993-09-16 | 1996-01-05 | Roussel Uclaf | Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus. |
| FR2716883B1 (fr) * | 1994-03-04 | 1996-04-26 | Roussel Uclaf | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. |
| FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
| MY119312A (en) * | 1995-10-06 | 2005-05-31 | Novartis Ag | At 1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys |
| CA2238975A1 (en) * | 1995-12-12 | 1997-06-19 | Merck & Co., Inc. | New use for losartan |
| EP0855392A3 (de) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1998
- 1998-01-15 EP EP98100595A patent/EP0855392A3/de not_active Withdrawn
- 1998-01-16 CA CA002227112A patent/CA2227112A1/en not_active Abandoned
- 1998-01-20 TR TR1998/00084A patent/TR199800084A3/tr unknown
- 1998-01-20 HR HR19741636.5A patent/HRP980025A2/hr not_active Application Discontinuation
- 1998-01-20 CZ CZ98185A patent/CZ18598A3/cs unknown
- 1998-01-20 AR ARP980100244A patent/AR011082A1/es unknown
- 1998-01-20 SK SK77-98A patent/SK284126B6/sk unknown
- 1998-01-20 ID IDP980065A patent/ID19574A/id unknown
- 1998-01-20 NZ NZ329606A patent/NZ329606A/en unknown
- 1998-01-21 NO NO19980273A patent/NO311570B1/no unknown
- 1998-01-21 AU AU52159/98A patent/AU738676B2/en not_active Ceased
- 1998-01-21 JP JP10022558A patent/JPH10204064A/ja not_active Abandoned
- 1998-01-21 CN CNB981042988A patent/CN1176911C/zh not_active Expired - Fee Related
- 1998-01-21 MY MYPI98000237A patent/MY121708A/en unknown
- 1998-01-21 IL IL12301398A patent/IL123013A/xx not_active IP Right Cessation
- 1998-01-21 US US09/010,181 patent/US6335451B1/en not_active Expired - Fee Related
- 1998-01-22 HU HU9800112A patent/HUP9800112A3/hu unknown
- 1998-01-22 KR KR1019980001810A patent/KR100529479B1/ko not_active IP Right Cessation
- 1998-01-22 PL PL324418A patent/PL191575B1/pl not_active IP Right Cessation
- 1998-01-22 BR BR9800436-0A patent/BR9800436A/pt not_active Application Discontinuation
- 1998-02-13 TW TW087100763A patent/TW593283B/zh not_active IP Right Cessation
- 1998-09-24 HK HK98110902A patent/HK1009814A1/xx not_active IP Right Cessation
-
2001
- 2001-10-30 US US09/984,469 patent/US6486189B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR011082A1 (es) | Heterociclos de 5 miembros con sustitucion por bifenilsulfonilo, su uso para la preparacion de un medicamento asi como medicamento que los contiene | |
| ATE5258T1 (de) | (piperidinylalkyl)chinazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
| BR0110240A (pt) | Composto, processo para a preparação de um composto, processo para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica | |
| ES2080919T3 (es) | Nuevos derivados de bencimidazol y de azabencimidazol, antagonistas de los receptores al tromboxano, sus procedimientos de preparacion, intermediarios de sintesis, composiciones que los contienen. | |
| ES2108375T3 (es) | Derivados de oxazolidinadiona, su produccion y utilizacion para reducir los niveles de azucares y lipidos en sangre. | |
| PE106099A1 (es) | Uso de derivados hidroxicumaranonas sustituidos como agentes antitumorales y antimetastasicos | |
| ES449596A1 (es) | Procedimiento para la preparacion de nuevos derivados de pi-rimidina. | |
| ES411341A1 (es) | Procedimiento para la preparacion de compuestos heteroci- clicos sustituidos por un radical guanidinilideno. | |
| CO5080802A1 (es) | Nuevos compuestos heterociclicos inhibidores de la fosfodiesteresa iv y su formulacion y uso como productos farmaceuticos | |
| ES455909A1 (es) | Procedimiento para preparar derivados de piperacina. | |
| KR960007566A (ko) | 신규한 퀴놀릴아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도 | |
| FR2394584A1 (fr) | Melanges de composes azoiques utilisables comme pigments | |
| CO5251476A1 (es) | Procedimiento para la preparacion de compuestos de pirazolo [4,3-d] pirimidin-7-onas-3-piridilsulfonilo e intermedios de los mismos | |
| ES425216A1 (es) | Procedimiento para la preparacion de nuevas triazolo - 1,5 - benzodiazepinas sustituidas. | |
| SE7812371L (sv) | Forfarande for framstellning av fenoxialkanolaminderivat | |
| NO802925L (no) | Nitrosoureaderivater og fremgangsmaate ved fremstilling derav | |
| PT99250A (pt) | Processo para a preparacao de derivados de piperazina | |
| ES381036A1 (es) | Medicamentos analgesicos a base de n-(aroilalkil) n'-(alfa-nols) piperacinas y sus derivados, y procedimiento para su obtencion. | |
| ES436742A1 (es) | Procedimiento para la preparacion de aceites cosmeticos protectores frente a la luz. | |
| ES449161A1 (es) | Procedimiento para la preparacion de nuevas amidinas. | |
| GB2021136A (en) | Protonated amino azobenzene dyestuffs, a process for their manufacture and their use for the colouration of synthetic polymeric materials | |
| DE68906827D1 (de) | Phenothiazinderivate, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
| DE69301639D1 (de) | Tetrahydronaphtalenderivate, ihre Herstellung und ihre therapeutische Verwendung | |
| ES465221A1 (es) | Procedimiento para la preparacion de nuevos derivados de 4- ter-buti-3'-clorodifenilamina con actividad antihistaminica. | |
| SE8100122L (sv) | Nya 2-aminometyl-6-halo-fenoler, framstellning derav och farmaceutiska kompositioner innehallande dessa |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |