AR010328A1 - Ester-amidas de acido 3-hidroxi-piridina-2-carboxilico, procedimiento para su preparacion, medicamentos y su utilizacion para la fabricacion demedicamentos - Google Patents
Ester-amidas de acido 3-hidroxi-piridina-2-carboxilico, procedimiento para su preparacion, medicamentos y su utilizacion para la fabricacion demedicamentosInfo
- Publication number
- AR010328A1 AR010328A1 ARP970105663A ARP970105663A AR010328A1 AR 010328 A1 AR010328 A1 AR 010328A1 AR P970105663 A ARP970105663 A AR P970105663A AR P970105663 A ARP970105663 A AR P970105663A AR 010328 A1 AR010328 A1 AR 010328A1
- Authority
- AR
- Argentina
- Prior art keywords
- medicines
- hydroxy
- procedure
- manufacture
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- BRARRAHGNDUELT-UHFFFAOYSA-N 3-hydroxypicolinic acid Chemical compound OC(=O)C1=NC=CC=C1O BRARRAHGNDUELT-UHFFFAOYSA-N 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- -1 glycyl-ethyl Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Ester-amidas de ácido 3-hidroxi-piridina-2-carboxílico, que comprende la formula general (I), en la cual R1, R2 y R3 son hidrogeno, A es un grupo-CH2, en el que un hidrogeno puede estar reemplazado por un grupo metilo, y B es -CO2G,verificánd ose que G es un radical orgánico, que convierte acompuestos de la formula (I) en profármacos, inclusive las sales fisiologicamente activas, estando exceptuada la (glicil-etil-éster)-amida deácido3-hidroxi-piridina-2-carboxílico, proce dimiento para su preparacion, medicamentos, y su utilizacion para la fabricacion de un medicamento para lainhibicion de la biosíntesis del cologeno y para el tratamiento de enfermedades fibroticas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19650215A DE19650215A1 (de) | 1996-12-04 | 1996-12-04 | 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010328A1 true AR010328A1 (es) | 2000-06-07 |
Family
ID=7813570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105663A AR010328A1 (es) | 1996-12-04 | 1997-12-02 | Ester-amidas de acido 3-hidroxi-piridina-2-carboxilico, procedimiento para su preparacion, medicamentos y su utilizacion para la fabricacion demedicamentos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6020350A (es) |
| EP (1) | EP0846685B1 (es) |
| JP (1) | JPH10168062A (es) |
| KR (1) | KR19980063725A (es) |
| CN (1) | CN1184104A (es) |
| AR (1) | AR010328A1 (es) |
| AT (1) | ATE214371T1 (es) |
| AU (1) | AU743750B2 (es) |
| BR (1) | BR9706129A (es) |
| CA (1) | CA2223366A1 (es) |
| CZ (1) | CZ383297A3 (es) |
| DE (2) | DE19650215A1 (es) |
| HU (1) | HUP9702345A2 (es) |
| NO (1) | NO309717B1 (es) |
| NZ (1) | NZ329299A (es) |
| PL (1) | PL323517A1 (es) |
| SG (1) | SG65705A1 (es) |
| TR (1) | TR199701490A2 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015616A1 (en) | 1998-09-16 | 2000-03-23 | Dow Agrosciences Llc | 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamides with (derivatised) hydroxyalkyl derivatives on the pyridine ring |
| WO2001005769A2 (en) | 1999-07-20 | 2001-01-25 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
| EP2295060B1 (en) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Treatment or prevention of ischemic or hypoxic conditions |
| CN102552263A (zh) | 2001-12-06 | 2012-07-11 | 法布罗根股份有限公司 | 提高内源性红细胞生成素(epo)的方法 |
| US8318703B2 (en) | 2001-12-06 | 2012-11-27 | Fibrogen, Inc. | Methods for improving kidney function |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| ATE470439T1 (de) | 2005-06-15 | 2010-06-15 | Fibrogen Inc | Verwendung von hif 1alfa modulatoren zur behandlung von krebs |
| WO2007101204A1 (en) * | 2006-02-27 | 2007-09-07 | Alcon Research, Ltd. | Method of treating glaucoma |
| US7745461B1 (en) | 2006-02-27 | 2010-06-29 | Alcon Research, Ltd. | Method of treating dry eye disorders |
| US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
| ES2619522T3 (es) * | 2006-03-30 | 2017-06-26 | Lg Electronics, Inc. | Un método y un aparato para descodificar/codificar una señal de video multivisión |
| MX2009000286A (es) * | 2006-06-26 | 2009-03-20 | Procter & Gamble | Inhibidores de prolil hidroxilasa y metodos de uso. |
| WO2009002533A1 (en) * | 2007-06-27 | 2008-12-31 | The Brigham And Women's Hospital, Inc. | Inflammatory bowel disease therapies |
| KR20140095105A (ko) * | 2009-11-06 | 2014-07-31 | 에르피오 세러퓨틱스 인코포레이티드 | 대장염 치료용 조성물 및 방법 |
| RU2602498C2 (ru) | 2011-06-06 | 2016-11-20 | Акебиа Терапеутикс Инк. | Соединения и композиции для стабилизации индуцируемого гипоксией фактора-2 альфа как способ лечения рака |
| NO2686520T3 (es) | 2011-06-06 | 2018-03-17 | ||
| HUE066123T2 (hu) | 2013-06-13 | 2024-07-28 | Akebia Therapeutics Inc | Készítmények és módszerek anémia kezelésére |
| TW201946625A (zh) | 2013-11-15 | 2019-12-16 | 美商阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途 |
| CA2937349A1 (en) * | 2014-01-23 | 2015-07-30 | Akebia Therapeutics, Inc. | Compositions and methods for treating ocular diseases |
| CN107427503A (zh) | 2015-01-23 | 2017-12-01 | 阿克比治疗有限公司 | 2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途 |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| US11324734B2 (en) | 2015-04-01 | 2022-05-10 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
| EP3305293A4 (en) * | 2015-05-28 | 2019-01-16 | Japan Tobacco Inc. | METHOD FOR THE TREATMENT OR PREVENTION OF NEPHROPATHIA DIABETICA |
| JP7440989B2 (ja) | 2018-05-09 | 2024-02-29 | アケビア セラピューティクス インコーポレイテッド | ２－［５－（３－クロロフェニル）－３－ヒドロキシピリジン－２－カルボニル］アミノ］酢酸を調製するための方法 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| IT201900021960A1 (it) * | 2019-11-22 | 2021-05-22 | Isagro Spa | Composti ad attività fungicida, loro composizioni agronomiche e relativo metodo di preparazione |
| CN112979541B (zh) * | 2019-12-17 | 2022-11-11 | 浙江大学 | 一种基于n-(3-羟基吡啶-2-羰基)甘氨酸的抗肿瘤药物增敏剂及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
| TW406076B (en) * | 1993-12-30 | 2000-09-21 | Hoechst Ag | Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals |
| IL135495A (en) * | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
-
1996
- 1996-12-04 DE DE19650215A patent/DE19650215A1/de not_active Withdrawn
-
1997
- 1997-11-24 DE DE59706602T patent/DE59706602D1/de not_active Expired - Lifetime
- 1997-11-24 EP EP97120537A patent/EP0846685B1/de not_active Expired - Lifetime
- 1997-11-24 AT AT97120537T patent/ATE214371T1/de not_active IP Right Cessation
- 1997-12-01 NO NO975513A patent/NO309717B1/no not_active IP Right Cessation
- 1997-12-02 TR TR97/01490A patent/TR199701490A2/xx unknown
- 1997-12-02 CZ CZ973832A patent/CZ383297A3/cs unknown
- 1997-12-02 NZ NZ329299A patent/NZ329299A/en unknown
- 1997-12-02 AR ARP970105663A patent/AR010328A1/es unknown
- 1997-12-02 AU AU46792/97A patent/AU743750B2/en not_active Ceased
- 1997-12-03 SG SG1997004280A patent/SG65705A1/en unknown
- 1997-12-03 HU HU9702345A patent/HUP9702345A2/hu unknown
- 1997-12-03 CN CN97125404A patent/CN1184104A/zh active Pending
- 1997-12-03 KR KR1019970065494A patent/KR19980063725A/ko not_active Withdrawn
- 1997-12-03 CA CA002223366A patent/CA2223366A1/en not_active Abandoned
- 1997-12-03 BR BR9706129A patent/BR9706129A/pt unknown
- 1997-12-04 PL PL97323517A patent/PL323517A1/xx unknown
- 1997-12-04 US US08/985,266 patent/US6020350A/en not_active Expired - Fee Related
- 1997-12-04 JP JP9334148A patent/JPH10168062A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9702345A2 (hu) | 2002-11-28 |
| NZ329299A (en) | 1998-11-25 |
| JPH10168062A (ja) | 1998-06-23 |
| EP0846685A1 (de) | 1998-06-10 |
| EP0846685B1 (de) | 2002-03-13 |
| NO975513D0 (no) | 1997-12-01 |
| MX9709438A (es) | 1998-06-30 |
| DE59706602D1 (de) | 2002-04-18 |
| HU9702345D0 (en) | 1998-03-02 |
| NO309717B1 (no) | 2001-03-19 |
| ATE214371T1 (de) | 2002-03-15 |
| PL323517A1 (en) | 1998-06-08 |
| CA2223366A1 (en) | 1998-06-04 |
| AU743750B2 (en) | 2002-02-07 |
| CN1184104A (zh) | 1998-06-10 |
| CZ383297A3 (cs) | 1998-06-17 |
| NO975513L (no) | 1998-06-05 |
| BR9706129A (pt) | 1999-05-18 |
| TR199701490A2 (xx) | 1998-06-22 |
| DE19650215A1 (de) | 1998-06-10 |
| US6020350A (en) | 2000-02-01 |
| SG65705A1 (en) | 1999-06-22 |
| AU4679297A (en) | 1998-06-11 |
| KR19980063725A (ko) | 1998-10-07 |
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