(Q40562808)

English

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

scientific article published on September 2003

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

A M Martelli

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

P L Tazzari

2

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

G Tabellini

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

R Bortul

4

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

A M Billi

5

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

L Manzoli

6

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

A Ruggeri

7

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

R Conte

8

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

L Cocco

9

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

publication date

1 September 2003

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

17

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1794-1805

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Acute lymphoblastic leukemia in children

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Low relapse rate in children with acute lymphoblastic leukemia after risk-directed therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Induction of apoptosis by cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Molecular signals in anti-apoptotic survival pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Retinoic acid resistance in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Insulin signaling pathways in time and space.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Flow cytometric detection of total and serine 473 phosphorylated Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

The biochemistry of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

PTEN: life as a tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

The modular phosphorylation and activation of p70s6k.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Etoposide-mediated deregulation of the G2M checkpoint in myeloid leukaemic cell lines results in loss of cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

How do inhibitory phosphatases work?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

21 January 2018

Acute myeloid leukemia in adults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

7 January 2021

based on heuristic

inferred from DOI database lookup

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

7 January 2021

based on heuristic

inferred from DOI database lookup

Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

7 January 2021

based on heuristic

inferred from DOI database lookup

Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Ad

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403044

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2403044

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Dimensions Publication ID

0 references

release_46vsukwmpbhnnlh5o2glkx6ze4

1 reference

https://api.fatcat.wiki/v0/release/46vsukwmpbhnnlh5o2glkx6ze4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40562808&oldid=2203789624"