(Q43761459)

26 November 2017

title

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer (English)

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26 November 2017

X Chen

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26 November 2017

H Thakkar

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26 November 2017

F Tyan

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26 November 2017

S Gim

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26 November 2017

H Robinson

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26 November 2017

C Lee

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26 November 2017

S K Pandey

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26 November 2017

C Nwokorie

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26 November 2017

N Onwudiwe

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26 November 2017

R K Srivastava

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26 November 2017

language of work or name

English

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publication date

1 September 2001

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26 November 2017

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26 November 2017

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26 November 2017

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26 November 2017

page(s)

6073-6083

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Apoptosis control by death and decoy receptors

26 November 2017

cites work

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TRAIL receptor-2 signals apoptosis through FADD and caspase-8

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

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Pten is essential for embryonic development and tumour suppression

21 January 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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The TRAIL to selective tumor death

21 January 2018

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

21 January 2018

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Akt signaling: linking membrane events to life and death decisions

21 January 2018

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

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Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

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Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

21 January 2018

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Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers

21 January 2018

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PTEN1 is frequently mutated in primary endometrial carcinomas

21 January 2018

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Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

21 January 2018

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Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules

21 January 2018

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Mitochondrial control of cell death

21 January 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

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21 January 2018

Cancer statistics, 1999.

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

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Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

21 January 2018

1 reference

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

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Apoptosis by death factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Structure and function of Fas/Fas ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

The receptor for the cytotoxic ligand TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Chemotherapy for advanced hormone refractory prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Anti-androgens and other hormonal therapies for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Human astrocytic brain tumors express AP02L/TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Characterization of two receptors for TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Intracellular mechanisms of TRAIL and its role in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Molecular characterization of mitochondrial apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Structural assets of a tumor suppressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Signalling by proteolysis: death receptors induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

The point of no return: mitochondria, caspases, and the commitment to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

TRAIL: a molecule with multiple receptors and control mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

How TRAIL kills cancer cells, but not normal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

Activity of TNF-related apoptosis-inducing ligand (TRAIL) in haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204736

1 reference

Dimensions Publication ID

26 November 2017

1011680283

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1 reference