(Q34177539)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

review article

1 reference

title

Molecular signals in anti-apoptotic survival pathways (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

D M O'Gorman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

publication date

1 January 2001

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5 November 2019

1 reference

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5 November 2019

volume

1 reference

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5 November 2019

issue

1 reference

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5 November 2019

page(s)

21-34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json

Death receptors: signaling and modulation

5 November 2019

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7 January 2021

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Analysis of mutations of neurofibromatosis type 1 gene and N-ras gene in acute myelogenous leukemia

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7 January 2021

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BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

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7 January 2021

The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia

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7 January 2021

RAS inhibitors in hematologic cancers: biologic considerations and clinical applications

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7 January 2021

Reovirus therapy of tumors with activated Ras pathway

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7 January 2021

Raf meets Ras: completing the framework of a signal transduction pathway

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021

Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

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7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

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7 January 2021

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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7 January 2021

The activation of phosphatidylinositol 3-kinase by Ras

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7 January 2021

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

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7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

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7 January 2021

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

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7 January 2021

A Bad kinase makes good

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7 January 2021

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

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7 January 2021

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

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7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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7 January 2021

The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.

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7 January 2021

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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7 January 2021

Multiple signals converging on NF-kappaB.

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NF-kappaB to the rescue: RELs, apoptosis and cellular transformation

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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7 January 2021

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

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7 January 2021

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

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7 January 2021

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

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7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

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7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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7 January 2021

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

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7 January 2021

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

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7 January 2021

Nuclear factor - kappaB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug

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7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

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7 January 2021

Signaling defect in the activation of caspase-3 and PKCdelta in human TUR leukemia cells is associated with resistance to apoptosis.

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7 January 2021

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

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7 January 2021

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

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7 January 2021

Cyclic AMP signaling and gene regulation

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7 January 2021

Transcriptional regulation by cyclic AMP.

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7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

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7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

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7 January 2021

mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response

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7 January 2021

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

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7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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7 January 2021

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

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7 January 2021

Conversion of Bcl-2 to a Bax-like death effector by caspases

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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7 January 2021

Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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7 January 2021

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

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7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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7 January 2021

Signal transduction by protein kinase C in mammalian cells

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7 January 2021

Signaling through protein kinase C

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7 January 2021

Regulation of protein kinase C and role in cancer biology.

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7 January 2021

Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer

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7 January 2021

Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression

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7 January 2021

Overproduction of protein kinase C causes disordered growth control in rat fibroblasts

1 reference

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7 January 2021

A mutant protein kinase C that can transform fibroblasts

1 reference

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7 January 2021

Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts

1 reference

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7 January 2021

Epsilon PKC acts like a marker of progressive malignancy in rat liver, but fails to enhance tumorigenesis in rat hepatoma cells in culture

1 reference

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7 January 2021

Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

P-glycoprotein, multidrug resistance and protein kinase C.

1 reference

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7 January 2021

Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

1 reference

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7 January 2021

Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein

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7 January 2021

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

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7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

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7 January 2021

Protein kinase Cepsilon is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway

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7 January 2021

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

1 reference

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7 January 2021

Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

1 reference

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7 January 2021

Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

The stress-activated protein kinase pathways

1 reference

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7 January 2021

AP-1 function and regulation

1 reference

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7 January 2021

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

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7 January 2021

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

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7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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7 January 2021

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

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7 January 2021

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1 reference

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7 January 2021

Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

1 reference

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7 January 2021

JNK activation is not required for Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Different mechanisms of c-Jun NH(2)-terminal kinase-1 (JNK1) activation by ultraviolet-B radiation and by oxidative stressors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Ras-dependent activation of c-Jun N-terminal kinase/stress-activated protein kinase in response to interleukin-3 stimulation in hematopoietic BaF3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Cellular transformation and malignancy induced by ras require c-jun

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Involvement of the bcl-2 gene in human follicular lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Bcl-xL overexpression restricts heat-induced apoptosis and influences hsp70, bcl-2, and Bax protein levels in FL5.12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

BCL-2 family: regulators of cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

The relationship between bcl-2 expression and response to chemotherapy in acute leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Biological features of leukaemic cells associated with autonomous growth and reduced survival in acute myeloblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Prognostic value of bcl-2 expression in invasive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

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7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Mitochondrial control of nuclear apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Mitochondrial control of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

The role of p53 in malignancy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

P53, cell cycle control and apoptosis: Implications for cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Growth factor modulation of p53-mediated growth arrest versus apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

CD95(APO-1/Fas)-mediated apoptosis: live and let die

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Sensitization of cancer cells treated with cytotoxic drugs to fas-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Chemotherapeutic drug-induced apoptosis in human leukaemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Expression of the Fas antigen on primary human leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Doxorubicin sensitizes human bladder carcinoma cells to Fas-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Inhibition of the protein kinase C pathway promotes anti-CD95-induced apoptosis in Jurkat T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

1 reference

7 January 2021

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Clinical pharmacology of UCN-01: initial observations and comparison to preclinical models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Promise and problems of Bcl-2 antisense therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2401998

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2401998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 November 2019

1042222845

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11243395%20AND%20SRC:MED&resulttype=core&format=json