(Q38156016)

29 August 2017

title

mTOR complexes in neurodevelopmental and neuropsychiatric disorders (English)

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29 August 2017

Lisa M Monteggia

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29 August 2017

Mauro Costa-Mattioli

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29 August 2017

language of work or name

English

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publication date

28 October 2013

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29 August 2017

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29 August 2017

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29 August 2017

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29 August 2017

page(s)

1537-1543

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The functions and regulation of the PTEN tumour suppressor

29 August 2017

cites work

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12 December 2020

The epidemiology of autism: a review.

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12 December 2020

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

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12 December 2020

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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12 December 2020

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

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12 December 2020

Acute suppression of spontaneous neurotransmission drives synaptic potentiation

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12 December 2020

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

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12 December 2020

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

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12 December 2020

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

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12 December 2020

mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons

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12 December 2020

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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12 December 2020

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

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12 December 2020

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

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12 December 2020

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

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12 December 2020

Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells.

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12 December 2020

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

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12 December 2020

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

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12 December 2020

Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

1 reference

12 December 2020

The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.

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12 December 2020

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

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12 December 2020

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

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12 December 2020

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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12 December 2020

Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy

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12 December 2020

Behavioral alterations in mice lacking the translation repressor 4E-BP2

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12 December 2020

Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors

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12 December 2020

Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice

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12 December 2020

The translational landscape of mTOR signalling steers cancer initiation and metastasis

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12 December 2020

Pten regulates neuronal arborization and social interaction in mice

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12 December 2020

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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12 December 2020

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

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12 December 2020

Molecular mechanisms of mTOR-mediated translational control

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12 December 2020

Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function

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12 December 2020

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission

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12 December 2020

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

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12 December 2020

Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

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12 December 2020

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

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12 December 2020

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.

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12 December 2020

Activation of mTORC2 by association with the ribosome

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12 December 2020

The PTEN phosphatase is essential for long-term depression of hippocampal synapses

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12 December 2020

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

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12 December 2020

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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12 December 2020

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

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12 December 2020

Translational control of long-lasting synaptic plasticity and memory

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12 December 2020

Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities

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12 December 2020

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

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12 December 2020

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

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12 December 2020

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

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12 December 2020

Brain-derived neurotrophic factor and neuropsychiatric disorders

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12 December 2020

PTEN signaling in autism spectrum disorders

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12 December 2020

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12 December 2020

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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12 December 2020

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

1 reference

12 December 2020

Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis

1 reference

12 December 2020

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

1 reference

12 December 2020

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial.

1 reference

12 December 2020

Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1.

1 reference

12 December 2020

Neuroanatomic observations of the brain in autism: a review and future directions

1 reference

12 December 2020

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

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12 December 2020

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

1 reference

12 December 2020

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.

1 reference

12 December 2020

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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12 December 2020

mTOR complex 2 signaling and functions

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12 December 2020

mTOR signaling in growth control and disease

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12 December 2020

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

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12 December 2020

mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice

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12 December 2020

Genomics, intellectual disability, and autism

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12 December 2020

TOR complex 2: a signaling pathway of its own.

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12 December 2020

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

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12 December 2020

Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder

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12 December 2020

Deforolimus (AP23573) a novel mTOR inhibitor in clinical development

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12 December 2020

Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia

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12 December 2020

The molecular biology of memory storage: a dialogue between genes and synapses

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12 December 2020

A unifying model for mTORC1-mediated regulation of mRNA translation.

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12 December 2020

Neurofibromin regulation of ERK signaling modulates GABA release and learning

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12 December 2020

Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex

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12 December 2020

Psychoneuroendocrinological links between chronic stress and depression.

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12 December 2020

mTORC2 controls actin polymerization required for consolidation of long-term memory.

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12 December 2020

Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice

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12 December 2020

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

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12 December 2020

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

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12 December 2020

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

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12 December 2020

Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

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12 December 2020

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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12 December 2020

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212

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12 December 2020

Essential role of brain-derived neurotrophic factor in adult hippocampal function

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12 December 2020

Targeting the endocannabinoid system in the treatment of fragile X syndrome.

1 reference

12 December 2020

mTOR kinase structure, mechanism and regulation

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12 December 2020

Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons

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12 December 2020

Mutations causing syndromic autism define an axis of synaptic pathophysiology

1 reference

12 December 2020

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

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12 December 2020

Clinical pharmacokinetics of everolimus

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12 December 2020

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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12 December 2020

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

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12 December 2020

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

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12 December 2020

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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12 December 2020

Reversing neurodevelopmental disorders in adults

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12 December 2020

Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia

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12 December 2020

Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

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12 December 2020

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

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12 December 2020

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

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12 December 2020

Identifiers

DOI

10.1038/NN.3546

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29 August 2017

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