(Q44978632)

English

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

scientific article published in July 2004

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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Lingfei Hou

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Eric Klann

2

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Europe PubMed Central

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30 December 2019

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1 July 2004

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30 December 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

24

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Europe PubMed Central

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30 December 2019

28

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

6352-6361

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

eIF4E activity is regulated at multiple levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An investigation into signal transduction mechanisms involved in DHPG-induced LTD in the CA1 region of the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosomal S6 kinase signaling and the control of translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of translation initiation by FRAP/mTOR

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term depression: a cellular basis for learning?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphoinositide 3-kinase and p70 S6 kinase regulate long-term potentiation in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered synaptic plasticity in a mouse model of fragile X mental retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group I metabotropic glutamate receptor (mGluR)-dependent long-term depression mediated via p38 mitogen-activated protein kinase is inhibited by previous high-frequency stimulation and activation of mGluRs and protein kinase C in the rat dentate gyr

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine dephosphorylation underlies DHPG-induced LTD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered presynaptic vesicle release and cycling during mGluR-dependent LTD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The group I metabotropic glutamate receptor agonist (S)-3,5-dihydroxyphenylglycine induces a novel form of depotentiation in the CA1 region of the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into fragile X syndrome: from molecules to neurobehaviors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure‐activity profiles of macrolactam immunosuppressant FK‐506 analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postsynaptic induction and presynaptic expression of hippocampal long-term depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors trigger postsynaptic protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K: downstream AKTion blocks apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of synaptoneurosomes from single rat hippocampal slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization of the mGluR1beta metabotropic glutamate receptor in the adult rodent forebrain: evidence for a differential distribution of mGluR1 splice variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0995-04.2004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15254091%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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