(Q38027944)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Meghan Coakley McCarthy

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Aoife P Kiely

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Sean Manning

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Caitriona M Long-Smith

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

1 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

Biochemical Society Transactions

8 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

721-727

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

8 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Frequency of stages of Alzheimer-related lesions in different age categories

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

21 January 2018

The genetics of ageing

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Protein homeostasis and aging in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

PI3K/Akt: getting it right matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Opposing activities protect against age-onset proteotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Functionally significant insulin-like growth factor I receptor mutations in centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Reduced insulin/IGF-1 signalling and human longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Association of FOXO3A variation with human longevity confirmed in German centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

mTOR-dependent signalling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

mTOR signaling: at the crossroads of plasticity, memory and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Fragile X: translation in action

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

IGF-I and the aging mammalian brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120080

21 January 2018

Identifiers

DOI

10.1042/BST20120080

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22817723%20AND%20SRC:MED&resulttype=core&format=json