(Q37979641)

26 August 2017

title

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes (English)

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26 August 2017

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Bart De Strooper

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26 August 2017

Iryna Benilova

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26 August 2017

Eric Karran

series ordinal

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26 August 2017

language of work or name

English

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publication date

29 January 2012

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26 August 2017

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

349-357

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

26 August 2017

cites work

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Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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A causative link between the structure of aberrant protein oligomers and their toxicity.

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

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12 December 2020

Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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12 December 2020

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

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12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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12 December 2020

Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses

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12 December 2020

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

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12 December 2020

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

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12 December 2020

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

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12 December 2020

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

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12 December 2020

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

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12 December 2020

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

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12 December 2020

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

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12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

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12 December 2020

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12 December 2020

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12 December 2020

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

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12 December 2020

Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease

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12 December 2020

Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation

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12 December 2020

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

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12 December 2020

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

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12 December 2020

A general model of prion strains and their pathogenicity

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12 December 2020

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

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12 December 2020

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

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12 December 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

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12 December 2020

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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12 December 2020

Molecular basis for passive immunotherapy of Alzheimer's disease

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12 December 2020

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

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12 December 2020

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life

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12 December 2020

Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons

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12 December 2020

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12 December 2020

Prions: protein aggregation and infectious diseases

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12 December 2020

Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

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12 December 2020

The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology

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12 December 2020

NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus

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12 December 2020

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

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12 December 2020

Monoclonal antibodies that target pathological assemblies of Abeta

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12 December 2020

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

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12 December 2020

Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons

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12 December 2020

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

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12 December 2020

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

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12 December 2020

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12 December 2020

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

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12 December 2020

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

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12 December 2020

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease

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12 December 2020

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

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12 December 2020

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.

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12 December 2020

G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease

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12 December 2020

Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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12 December 2020

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

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12 December 2020

Characterisation of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates

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12 December 2020

In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

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12 December 2020

A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.

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12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

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12 December 2020

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

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12 December 2020

Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

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12 December 2020

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

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12 December 2020

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

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12 December 2020

The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide

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12 December 2020

Conformational Abs recognizing a generic amyloid fibril epitope

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12 December 2020

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

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12 December 2020

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

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12 December 2020

Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide

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12 December 2020

De novo induction of amyloid-β deposition in vivo

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Crossref

https://api.crossref.org/works/10.1038%2FNN.3028

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NN.3028

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Dimensions Publication ID

26 August 2017

1051054678

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