(Q37776792)

23 August 2017

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title

Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house (English)

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23 August 2017

0 references

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reactive oxygen species

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20673809

14 June 2024

Priyamvada Rai

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23 August 2017

language of work or name

English

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publication date

29 July 2010

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full work available at URL

23 August 2017

https://api.elsevier.com/content/article/PII:S1383571810002731?httpAccept=text/xml

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https://api.crossref.org/works/10.1016/J.MRGENTOX.2010.07.010

https://api.elsevier.com/content/article/PII:S1383571810002731?httpAccept=text/plain

14 June 2024

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2010.07.010

14 June 2024

1 reference

23 August 2017

volume

703

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23 August 2017

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23 August 2017

page(s)

71-81

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The serial cultivation of human diploid cell strains

23 August 2017

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Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study

14 June 2024

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

14 June 2024

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells

14 June 2024

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Human lens cells have an in vitro proliferative capacity inversely proportional to the donor age

14 June 2024

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Cellular senescence in a cloned strain of bovine fetal aortic endothelial cells

14 June 2024

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Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin

14 June 2024

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Isolation and growth of human mammary epithelial cells

14 June 2024

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Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells

14 June 2024

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Cellular senescence and organismal aging

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Cellular senescence, ageing and disease

14 June 2024

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Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

14 June 2024

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Skin fibroblasts from aged Fischer 344 rats undergo similar changes in replicative life span but not immortalization with caloric restriction of donors

14 June 2024

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14 June 2024

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14 June 2024

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14 June 2024

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14 June 2024

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Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

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Oxidative DNA damage and senescence of human diploid fibroblast cells.

14 June 2024

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Superoxide dismutase 1 knock-down induces senescence in human fibroblasts

14 June 2024

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Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.

14 June 2024

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NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

14 June 2024

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Accumulation of DNA strand breaks and methotrexate cytotoxicity

14 June 2024

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Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat

14 June 2024

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DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

14 June 2024

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Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence

14 June 2024

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Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks

14 June 2024

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p53 mediates senescence-like arrest induced by chronic replicational stress

14 June 2024

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Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

14 June 2024

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Measurement of 7,8-dihydro-8-oxo-2'-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry

14 June 2024

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14 June 2024

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14 June 2024

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Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents

14 June 2024

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The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity

14 June 2024

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14 June 2024

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14 June 2024

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Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.

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Developmental differences in the immortalization of lung fibroblasts by telomerase

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Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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Persistent oxidative stress in cancer

14 June 2024

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Production of large amounts of hydrogen peroxide by human tumor cells

14 June 2024

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The thioredoxin-thioredoxin reductase system: over-expression in human cancer

14 June 2024

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Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

14 June 2024

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Reactive oxygen species in tumor progression

14 June 2024

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ROS, stress-activated kinases and stress signaling in cancer

14 June 2024

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Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

14 June 2024

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

14 June 2024

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

14 June 2024

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

14 June 2024

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Mitochondrial dysfunction contributes to oncogene-induced senescence.

14 June 2024

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ras oncogenes in human cancer: a review

14 June 2024

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8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells

14 June 2024

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p19ARF directly and differentially controls the functions of c-Myc independently of p53.

14 June 2024

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14 June 2024

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14 June 2024

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Cellular senescence mechanisms in chronic wound healing

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Unexpected pieces to the senescence puzzle

14 June 2024

133

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

14 June 2024

134

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Cancer and aging: a model for the cancer promoting effects of the aging stroma

14 June 2024

135

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Effects of 7,8-dihydro-8-oxo-deoxyguanosine on antigen challenge in ovalbumin-sensitized mice may be mediated by suppression of Rac.

14 June 2024

136

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Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis

14 June 2024

137

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Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

14 June 2024

138

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Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei

14 June 2024

139

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Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

14 June 2024

140

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The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation

14 June 2024

141

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SV40 T antigen alone drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts

14 June 2024

142

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Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo

14 June 2024

143

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Delayed kinetics of DNA double-strand break processing in normal and pathological aging

14 June 2024

144

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Normal human oral keratinocytes demonstrate abnormal DNA end joining activity during replicative senescence

14 June 2024

145

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Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

14 June 2024

146

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

14 June 2024

147

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Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

14 June 2024

148

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Diversity of gene expression in adenocarcinoma of the lung

14 June 2024

149

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Oxidized guanine lesions and hOgg1 activity in lung cancer.

14 June 2024

150

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Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer

14 June 2024

151

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DNA repair activity for oxidative damage and risk of lung cancer

14 June 2024

152

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Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.

14 June 2024

154

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DNA damage signals induction of fas ligand in tumor cells.

14 June 2024

155

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Reactive oxygen species in cancer cells: live by the sword, die by the sword.

14 June 2024

157

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Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue

14 June 2024

158

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Oxidative damage in nucleic acids and Parkinson's disease.

14 June 2024

159

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14 June 2024

160

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Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5.

14 June 2024

161

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NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity

14 June 2024

162

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14 June 2024

Identifiers

1 reference

23 August 2017

1 reference