(Q35998764)

11 August 2017

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title

Aurora-A - a guardian of poles (English)

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11 August 2017

Tomotoshi Marumoto

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11 August 2017

Dongwei Zhang

series ordinal

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11 August 2017

Hideyuki Saya

series ordinal

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11 August 2017

language of work or name

English

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publication date

1 January 2005

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11 August 2017

published in

Nature Reviews Cancer

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11 August 2017

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11 August 2017

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11 August 2017

page(s)

42-50

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Mitotic kinases as regulators of cell division and its checkpoints

11 August 2017

cites work

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Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C

21 January 2018

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Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1.

21 January 2018

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

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Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers

21 January 2018

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Functional characterization of BRCA1 sequence variants using a yeast small colony phenotype assay

21 January 2018

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Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers.

21 January 2018

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Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

21 January 2018

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Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

21 January 2018

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Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

21 January 2018

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Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis

21 January 2018

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

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TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos

21 January 2018

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TACC1-chTOG-Aurora A protein complex in breast cancer

21 January 2018

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Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

21 January 2018

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Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.

21 January 2018

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The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin

21 January 2018

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The ran GTPase regulates mitotic spindle assembly.

21 January 2018

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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

21 January 2018

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Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein

21 January 2018

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The mitotic spindle: a self-made machine

21 January 2018

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TPX2, A novel xenopus MAP involved in spindle pole organization

21 January 2018

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hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division

21 January 2018

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Human TPX2 is required for targeting Aurora-A kinase to the spindle

21 January 2018

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The Xenopus laevis aurora/Ip11p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle

21 January 2018

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

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Mitotic mechanics: the auroras come into view

21 January 2018

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CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function

21 January 2018

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Signaling to chromatin through histone modifications

21 January 2018

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CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

21 January 2018

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

21 January 2018

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Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

21 January 2018

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The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A.

21 January 2018

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Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

21 January 2018

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Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

21 January 2018

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Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells

21 January 2018

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AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer

21 January 2018

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

21 January 2018

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Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

21 January 2018

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

21 January 2018

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

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p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.

21 January 2018

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p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption

21 January 2018

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Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

21 January 2018

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

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Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

21 January 2018

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

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Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint

21 January 2018

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Cancer genes and the pathways they control

21 January 2018

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Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1

21 January 2018

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

21 January 2018

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Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

21 January 2018

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Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae

21 January 2018

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INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.

21 January 2018

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AIM-1: a mammalian midbody-associated protein required for cytokinesis

21 January 2018

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Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

21 January 2018

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21 January 2018

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Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora/Ipl1p-related kinase from rat

21 January 2018

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Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process

21 January 2018

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Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase

21 January 2018

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Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

21 January 2018

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Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells

21 January 2018

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Megakaryocytes express functional Aurora-B kinase in endomitosis

21 January 2018

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Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.

21 January 2018

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Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes

21 January 2018

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Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

21 January 2018

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Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity

21 January 2018

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The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis

21 January 2018

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Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins

21 January 2018

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The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.

21 January 2018

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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

21 January 2018

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Mitotic kinase expression and colorectal cancer progression

21 January 2018

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The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5

31 March 2020

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A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

31 March 2020

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A novel mechanism for activation of the protein kinase Aurora A

31 March 2020

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Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

31 March 2020

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Overexpression and amplification of Aurora-A in hepatocellular carcinoma

31 March 2020

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

31 March 2020

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Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

31 March 2020

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Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

31 March 2020

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STK15 polymorphism and breast cancer risk in a population-based study

31 March 2020

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Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells

31 March 2020

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Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

31 March 2020

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Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1526

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11 August 2017

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