(Q28275089)

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Cancer genes and the pathways they control

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Cancer genes and the pathways they control (English)

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Bert Vogelstein

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Bert Vogelstein

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Kenneth W. Kinzler

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Kenneth W Kinzler

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publication date

August 2004

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Nature Medicine

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10

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8

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789-99

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Mutations of the BRAF gene in human cancer

1 reference

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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Surfing the p53 network

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Targeting HIF-1 for cancer therapy

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Genetic instabilities in human cancers

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

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MutS homologs in mammalian cells

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Worms gang up on bacteria

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A vision for the future of genomics research

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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A census of human cancer genes

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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Lessons from hereditary colorectal cancer

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Targeting RAS signalling pathways in cancer therapy

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The phosphoinositide 3-kinase pathway

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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A role for mitochondrial enzymes in inherited neoplasia and beyond

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The Hedgehog response network: sensors, switches, and routers

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Signal Transduction and the Control of Gene Expression

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Dissemination and growth of cancer cells in metastatic sites

1 reference

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Signaling--2000 and beyond

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Role of angiogenesis in tumor growth and metastasis

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21 April 2017

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

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21 April 2017

Exploring the new world of the genome with DNA microarrays

1 reference

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21 April 2017

The history of cancer epigenetics

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21 April 2017

Cancer genetics

1 reference

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7 January 2021

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DNA damage and repair

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7 January 2021

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Tumor progression: a brief historical perspective

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Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus

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Cancer modeling in the modern era: progress and challenges

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7 January 2021

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Worms, life, and death (Nobel lecture).

1 reference

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7 January 2021

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The retinoblastoma tumour suppressor in development and cancer

1 reference

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Decision making by p53: life, death and cancer

1 reference

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7 January 2021

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Perspectives in studies of human tumor viruses

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Human papillomavirus immortalization and transformation functions

1 reference

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Oncogenic DNA viruses

1 reference

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Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability.

1 reference

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7 January 2021

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The critical role of chromosome translocations in human leukemias.

1 reference

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Are tumours angiogenesis-dependent?

1 reference

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7 January 2021

based on heuristic

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Know thy neighbor: stromal cells can contribute oncogenic signals

1 reference

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7 January 2021

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Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

1 reference

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based on heuristic

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Clinical translation of angiogenesis inhibitors

1 reference

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7 January 2021

based on heuristic

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

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7 January 2021

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Sequence-based cancer genomics: progress, lessons and opportunities

1 reference

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7 January 2021

based on heuristic

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Multiple mutations and cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The significance of unstable chromosomes in colorectal cancer.

1 reference

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7 January 2021

based on heuristic

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Genomic instability--the engine of tumorigenesis?

1 reference

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7 January 2021

based on heuristic

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Prevalence of somatic alterations in the colorectal cancer cell genome

1 reference

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7 January 2021

based on heuristic

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Genomic microarrays in human genetic disease and cancer

1 reference

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7 January 2021

based on heuristic

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ATM: genome stability, neuronal development, and cancer cross paths

1 reference

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7 January 2021

based on heuristic

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Connecting chromosomes, crisis, and cancer

1 reference

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7 January 2021

based on heuristic

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Mutations and aneuploidy: co-conspirators in cancer?

1 reference

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7 January 2021

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Inactivation of hCDC4 can cause chromosomal instability

1 reference

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7 January 2021

based on heuristic

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Hallmarks of senescence in carcinogenesis and cancer therapy

1 reference

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7 January 2021

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Critical determinants of metastasis

1 reference

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7 January 2021

based on heuristic

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Host genetics and tumour metastasis

1 reference

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

1 reference

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Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis?

1 reference

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7 January 2021

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In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

based on heuristic

inferred from DOI database lookup

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

based on heuristic

inferred from DOI database lookup

Wildtype Kras2 can inhibit lung carcinogenesis in mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

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Development. Making sense of the sensory lineage

1 reference

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Eukaryotic mismatch repair: an update

1 reference

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7 January 2021

based on heuristic

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Hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

based on heuristic

inferred from DOI database lookup

Gastrointestinal cancer of the microsatellite mutator phenotype pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

based on heuristic

inferred from DOI database lookup

Genomic instability in neoplasia.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Gene discovery using the serial analysis of gene expression technique: implications for cancer research

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

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The fundamental role of epigenetic events in cancer

1 reference

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7 January 2021

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A resource for large-scale RNA-interference-based screens in mammals.

1 reference

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7 January 2021

based on heuristic

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Serum proteomics in cancer diagnosis and management.

1 reference

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7 January 2021

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Looking beyond morphology: cancer gene expression profiling using DNA microarrays

1 reference

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7 January 2021

based on heuristic

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A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

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Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression

1 reference

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7 January 2021

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Senescence: does it all happen at the ends?

1 reference

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7 January 2021

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Telomere dysfunction and the initiation of genome instability.

1 reference

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Telomeres and telomerase

1 reference

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7 January 2021

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Beginning to understand the end of the chromosome

1 reference

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7 January 2021

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Microarray reality checks in the context of a complex disease

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

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Human acute myeloid leukemia stem cells

1 reference

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7 January 2021

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Reconstruction of functionally normal and malignant human breast tissues in mice

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7 January 2021

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1 reference

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Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib

1 reference

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based on heuristic

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1 reference

https://api.crossref.org/works/10.1038%2FNM1087

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based on heuristic

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Biology of gastrointestinal stromal tumors: KIT mutations and beyond

1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

based on heuristic

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Cell death: critical control points

1 reference

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7 January 2021

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1 reference

https://api.crossref.org/works/10.1038%2FNM1087

7 January 2021

based on heuristic

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Overview of the clinical efficacy of investigational anticancer drugs

1 reference

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1 reference

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7 January 2021

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Shedding light onto live molecular targets

1 reference

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7 January 2021

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Emerging molecular markers of cancer.

1 reference

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7 January 2021

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The discovery of receptor tyrosine kinases: targets for cancer therapy

1 reference

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To cycle or not to cycle: a critical decision in cancer.

1 reference

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Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer

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Ways of dying: multiple pathways to apoptosis.

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Cell metabolism in the regulation of programmed cell death

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A matter of life and death

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The Runx genes: lineage-specific oncogenes and tumor suppressors

1 reference

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