(Q27860785)

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

scientific article (publication date: 13 June 2003)

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Europe PubMed Central

Mechanisms of TGF-beta signaling from cell membrane to the nucleus (English)

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Joan Massagué Solé

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publication date

13 June 2003

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113

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6

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685-700

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TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

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Smads as transcriptional co-modulators

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SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling

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Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators

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The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

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MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

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Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

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The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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Determinants of specificity in TGF-beta signal transduction.

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EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1.

1 reference

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Physical basis of a protein-DNA recognition code

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STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

1 reference

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Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension

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Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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Nomenclature: vertebrate mediators of TGFbeta family signals

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Smads: transcriptional activators of TGF-beta responses

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

1 reference

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A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity

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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

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Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

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Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway

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Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

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Transport between the cell nucleus and the cytoplasm

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Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

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Identification of a binding site on the type II activin receptor for activin and inhibin

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Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase

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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly

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Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

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Mh1 domain of Smad is a degraded homing endonuclease

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Control of Smad7 stability by competition between acetylation and ubiquitination

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Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

1 reference

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Developmental biology. A twist on embryonic signalling.

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

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1 reference

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1 reference

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Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

1 reference

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7 January 2021

based on heuristic

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The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Stoichiometry of active smad-transcription factor complexes on DNA

1 reference

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7 January 2021

based on heuristic

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Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

1 reference

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based on heuristic

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Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter

1 reference

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based on heuristic

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Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

1 reference

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7 January 2021

based on heuristic

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Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of Smad complexes with tripartite DNA-binding sites

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the BMP-2-BRIA ectodomain complex

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Initial sequencing and analysis of the human genome

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Noggin antagonizes BMP signaling to create a niche for adult neurogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski/Sno and TGF-beta signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase complement of the human genome

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Solution structure of the chick TGFbeta type II receptor ligand-binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

How cells read TGF-beta signals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleocytoplasmic transport: the soluble phase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF beta-related pathways. Roles in Caenorhabditis elegans development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of Smad1 activation by receptor kinase phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cripto, a multifunctional partner in signaling: molecular forms and activities

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The EGF-CFC gene family in vertebrate development.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Repression of p15INK4b expression by Myc through association with Miz-1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The Cystine-Knot Growth-Factor Superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling inputs converge on nuclear effectors in TGF-beta signaling

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of cell proliferation by Smad proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple modes of repression by the Smad transcriptional corepressor TGIF

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of Smad2 recognition by the Smad anchor for receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Formation of a stable heterodimer between Smad2 and Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal Structure of a Phosphorylated Smad2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Importin beta mediates nuclear translocation of Smad 3

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900432-X

7 January 2021

based on heuristic

inferred from DOI database lookup

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