(Q40506957)

21 September 2017

title

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. (English)

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21 September 2017

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Qiyuan Liu

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21 September 2017

Satoshi Kaneko

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21 September 2017

Lin Yang

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21 September 2017

Richard I Feldman

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21 September 2017

Santo V Nicosia

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21 September 2017

Jiandong Chen

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21 September 2017

Jin Q Cheng

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21 September 2017

language of work or name

English

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publication date

6 October 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

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21 September 2017

page(s)

52175-52182

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 September 2017

cites work

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Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation

21 January 2018

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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

21 January 2018

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Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.

21 January 2018

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A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

21 January 2018

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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

21 January 2018

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Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells

21 January 2018

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Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

21 January 2018

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Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter

21 January 2018

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A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue.

21 January 2018

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

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pEg2 aurora-A kinase, histone H3 phosphorylation, and chromosome assembly in Xenopus egg extract

21 January 2018

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N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses

21 January 2018

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Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

21 January 2018

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Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes

21 January 2018

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Human TPX2 is required for targeting Aurora-A kinase to the spindle

21 January 2018

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

21 January 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

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A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

21 January 2018

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Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

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Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

21 January 2018

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Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

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Phosphorylation studies on rat p53 using the baculovirus expression system. Manipulation of the phosphorylation state with okadaic acid and influence on DNA binding

21 January 2018

1 reference

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Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

21 January 2018

1 reference

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21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M406802200

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21 September 2017

1 reference