(Q28241789)

object named as

Barry V L Potter

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author name string

Enza Piccolo

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Sara Vignati

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Tania Maffucci

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Pasquale F Innominato

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Andrew M Riley

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Massimo Broggini

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Stefano Iacobelli

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Paolo Innocenti

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Marco Falasca

Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate

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language of work or name

English

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publication date

4 March 2004

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1754-65

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

The role of phosphoinositide 3-kinase lipid products in cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

Transport of the highly charged myo-inositol hexakisphosphate molecule across the red blood cell membrane: a phase transfer and biological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

Mechanism of activation of protein kinase B by insulin and IGF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Patterns within protein/polyphosphoinositide interactions provide specific targets for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

PI3K: downstream AKTion blocks apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Mechanisms of cancer drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Pleckstrin domain homology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Pleckstrin homology domains.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Extracellular matrix regulation of drug resistance in small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

The pleckstrin homology domain: an intriguing multifunctional protein module

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Assessing the omnipotence of inositol hexakisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

Phosphoinositide 3-kinases: A conserved family of signal transducers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021

p27Kip1 overexpression causes apoptotic death of mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207296

7 January 2021