(Q47895700)

6 February 2018

title

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains (English)

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6 February 2018

author name string

M A L

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6 February 2018

M F

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6 February 2018

J S

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6 February 2018

K F

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6 February 2018

publication date

1 June 1997

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6 February 2018

published in

Trends in Cell Biology

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6 February 2018

volume

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6 February 2018

issue

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6 February 2018

page(s)

237-242

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6 February 2018

Pleckstrin domain homology

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A putative modular domain present in diverse signaling proteins

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The pleckstrin homology domain: an intriguing multifunctional protein module

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7 January 2021

PH domain: the first anniversary

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Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

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7 January 2021

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

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7 January 2021

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

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7 January 2021

Structure of the binding site for inositol phosphates in a PH domain

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7 January 2021

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

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7 January 2021

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

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The role of the PH domain in the signal-dependent membrane targeting of Sos.

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High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate

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7 January 2021

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

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Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane

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Phosphatidylinositol 4,5-bisphosphate binding to the pleckstrin homology domain of phospholipase C-delta1 enhances enzyme activity

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Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

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7 January 2021

Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains

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7 January 2021

Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells

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Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity

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Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain.

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Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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7 January 2021

Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase

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7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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7 January 2021

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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7 January 2021

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7 January 2021

Akt signaling: linking membrane events to life and death decisions

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7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

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7 January 2021

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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7 January 2021

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

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7 January 2021

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

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7 January 2021

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

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7 January 2021

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.

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7 January 2021

10.1016/S0962-8924(97)01065-9

Identifiers

DOI

1 reference

6 February 2018

1 reference

6 February 2018