(Q28138926)

English

MDM2--master regulator of the p53 tumor suppressor protein

scientific article (publication date: 25 January 2000)

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

0 references

1 reference

Europe PubMed Central

MDM2--master regulator of the p53 tumor suppressor protein (English)

0 references

author name string

J Momand

1

0 references

H H Wu

2

0 references

G Dasgupta

3

0 references

language of work or name

0 references

publication date

25 January 2000

0 references

0 references

242

0 references

1-2

0 references

15-29

0 references

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution conformation of an essential region of the p53 transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of the p53 and mdm-2 Interaction Domains

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The INK4a/ARF tumor suppressor: one gene--two products--two pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Functions of the MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Translational regulation of human p53 gene expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The mdm2 proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The ubiquitin system

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of the specific DNA binding function of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The cellular oncogene p53 can be activated by mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Metal and RNA binding properties of the hdm2 RING finger domain

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

MDM2--arbiter of p53's destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A new class of yeast transcriptional activators

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mdm-2: "big brother" of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The MDM2 gene amplification database

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 Protein exhibits 3'-to-5' exonuclease activity

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mdm2: keeping p53 under control

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a growth suppression domain within the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural aspects of the p53 protein in relation to gene evolution: a second look.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

MDM2 interacts with MDMX through their RING finger domains

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of p53 with its consensus DNA-binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

MDM2 suppresses p73 function without promoting p73 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0378-1119%2899%2900487-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28138926&oldid=1609186238"