Thais Cesar
São Paulo State University, Food and Nutrition, Faculty Member
- Thais Borges Cesar is an Associate Professor of Nutrition, Faculty of Pharmaceutical Sciences, Sao Paulo State Univer... moreThais Borges Cesar is an Associate Professor of Nutrition, Faculty of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil. She has a BS in Biology from Federal University of São Carlos, Brazil and a Ph.D. in Food Science and Nutrition, University of Sao Paulo, Brazil. She did post-doctoral at the Boston University, from 1996 to 1998, and at the Citrus and Subtropical Products Research Laboratory, ARS-USDA, establishing a cooperative research between USDA and UNESP since 2010. In the last decade, Dr Cesar’s scientific focus is investigate the nutritional and metabolic properties of citrus fruits in clinical studies and animal models, regarding to the effect of its bioactive compounds as a protection factor against the development of chronic diseases.edit
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Determina Determination of the Users' Profile and of the Chemical and Nutritional Tion of the Users' Profile and of the Chemical and Nutritional Tion of the Users' Profile and of the Chemical and Nutritional Tion of the Users' Profile and of the Chemical and Nutritional Tion of the Users' Profile...more
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In this study, the pharmacokinetics of oral doses of eriodictyol in 1% sodium carboxymethylcellulose and in saline/PEG400/Tween80 (75/20/5, v/v/v) in rats were compared. The pharmacokinetics of eriocitrin administered as a dissolved... more
In this study, the pharmacokinetics of oral doses of eriodictyol in 1% sodium carboxymethylcellulose and in saline/PEG400/Tween80 (75/20/5, v/v/v) in rats were compared. The pharmacokinetics of eriocitrin administered as a dissolved solution in water were also characterized. Metabolites of eriodictyol and eriocitrin in whole blood consisted mainly of eriodictyol, homoeriodictyol, and hesperetin glucuronides and ring-fission metabolites. In whole blood, no free nonconjugated flavanone aglycones were detected. Significant differences were observed in the pharmacokinetics of eriodictyol administered as a suspension in 1% sodium carboxymethylcellulose versus administration as a dissolved solution in saline/PEG400/Tween80 (75/20/5, v/v/v). At a dose of 25 mg kg-1 eriodictyol administered with 1% sodium carboxymethylcellulose, a biphasic pharmacokinetic curve was observed, while only a single concentration peak was observed following an administration of 25 mg kg-1 eriodictyol dissolved in saline/PEG400/Tween80 (75/20/5, v/v/v). For all trials, the pharmacokinetics of eriodictyol differed from those of eriocitrin dissolved in water.
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Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats... more
Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%.
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Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8‐heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high‐fat diet (HFD) in C57BL/6J mice. In the first 4 weeks,... more
Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8‐heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high‐fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre‐existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti‐inflammatory cytokine, IL‐10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites.
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Background: Citrus polymethoxylated flavones (PMFs) reduce the synthesis of liver lipoproteins in animal and in vitro cell assays, but few studies have evaluated the direct effects of their metabolites on this highly regulated process.... more
Background: Citrus polymethoxylated flavones (PMFs) reduce the synthesis of liver lipoproteins in animal and in vitro cell assays, but few studies have evaluated the direct effects of their metabolites on this highly regulated process. Objective: The aim of the study was to investigate the effects of representative metabolites of PMF on the secretion of liver lipoproteins using the mammalian cell Huh7.5. Method: In this study, the influences of three PMFs and five previously isolated PMF metabolites on hepatic apoB-100 secretion and microsomal transfer protein (MTP) activity were evaluated. Tangeretin (TAN), nobiletin (NOB) and 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), their glucuronides (TAN-Gluc, NOB-Gluc and HMF-Gluc) and oxidatively demethylated metabolites (TAN-OH, NOB-OH, HMF-OH), were incubated with Huh7.5 cells to measure their inhibitory effects on lipid synthesis. Results: The results showed that TAN, HMF and TAN-OH reduced the secretion of apoB-100 in a dose-dependent ma...
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Previous studies have shown that fresh squeezed orange juice or juice from reconstituted concentrate can help prevent the development of atherosclerosis. Pasteurized orange juice presently represents the major orange juice available in... more
Previous studies have shown that fresh squeezed orange juice or juice from reconstituted concentrate can help prevent the development of atherosclerosis. Pasteurized orange juice presently represents the major orange juice available in the market, and because of this, it becomes necessary to determine the healthy benefits associated with this product. In this study we investigated the effect of regular consumption of pasteurized orange juice on the nutritional status, biochemical profile, and arterial blood pressure in healthy men and women. Men and women volunteered to consume pasteurized orange juice (500 mL·d–1 and 750 mL·d–1, respectively), for 8 weeks. Anthropometric, biochemical, hemodynamic, and dietary assessments were evaluated at baseline and at the end of the experimental period. Total cholesterol and LDL-C significantly decreased in both men and women after the consumption of orange juice, and an increase in HDL-C level was detected exclusively in women. Fasting glucose,...
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Universidade Estadual Paulista, Departamento de Alimentos e Nutricao, Faculdade de Ciencias Farmaceuticas de Araraquara
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A infeccao pelo virus da hepatite C e um problema mundial de saude publica. Afeta cerca de 170 a 250 milhoes de individuos no mundo podendo levar a complicacoes como a cirrose e o hepatocarcinoma. Pacientes com hepatite C cronica, na... more
A infeccao pelo virus da hepatite C e um problema mundial de saude publica. Afeta cerca de 170 a 250 milhoes de individuos no mundo podendo levar a complicacoes como a cirrose e o hepatocarcinoma. Pacientes com hepatite C cronica, na maioria das vezes, tem ingestao inadequada de nutrientes, macronutrientes e micronutrientes, o que induz a modifi cacoes do estado nutricional. A suplementacao com vitamina C neste tipo de enfermidade tem demonstrado beneficios, no entanto as informacoes disponiveis sao muito limitadas. O estudo teve como objetivo avaliar e testar o efeito da ingestao regular do suco de laranja sobre o estado nutricional e dietetico de pacientes com hepatite C cronica. Participaram do estudo 23 pacientes voluntarios, sendo 13 homens e 10 mulheres, atendidos no Servico Especial de Saude de Araraquara (SESA). Os pacientes consumiram durante 8 semanas 500 mL.d-1 de suco de laranja. No inicio do estudo e apos as 8 semanas de intervencao com suco os pacientes foram submetidos a avaliacao dietetica e antropometrica. Esta intervencao dietetica nao alterou o estado nutricional dos pacientes.
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Objective: To assess the dietary intake and overall diet quality of female soccer players before the competitive games. Methods: This descriptive and cross-sectional study included 21 women aged 20.8±4.5 years from a professional soccer... more
Objective: To assess the dietary intake and overall diet quality of female soccer players before the competitive games. Methods: This descriptive and cross-sectional study included 21 women aged 20.8±4.5 years from a professional soccer team. Their nutritional status and dietary adequacy during the training period, before competition season, were assessed. Dietary intake was assessed by three 24-hour recalls, one food frequency questionnaire, and the Healthy Eating Index, an overall diet quality index based on food group intake. Results: The athletes have shown proper nutritional status, but a diet deficient in energy due largely to low carbohydrate intake. On the other hand, the intakes of protein, fatty acids, and sodium were above the recommended intakes, even for athletes. Diet quality assessment by the Healthy Eating Index - 2010 resulted in a mean score of 54.6 points of a maximum of 100, indicating a need of improving the overall diet quality. Conclusion: The study found that...
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Neste estudo foi comparada a prevalência de sobrepeso e obesidade infantil segundo dois métodos de referência, a partir de dados antropométricos de 3751 pré-escolares (60% do total) da rede municipal de ensino de Araraquara, SP. Com base... more
Neste estudo foi comparada a prevalência de sobrepeso e obesidade infantil segundo dois métodos de referência, a partir de dados antropométricos de 3751 pré-escolares (60% do total) da rede municipal de ensino de Araraquara, SP. Com base nas variáveis de peso e altura, as prevalências de sobrepeso e obesidade foram calculadas pelos métodos de Cole e Escore Z. As prevalências médias encontradas de sobrepeso e obesidade pelo Escore Z foram 15% e 29,5% respectivamente, enquanto por Cole, as prevalências de sobrepeso e obesidade foram 6,3% e 12,3%, mostrando que o segundo método estimou menores prevalências para as mesmas características. As variações nas estimativas de sobrepeso e obesidade, considerando os dois critérios, ressaltam a necessidade de estudos populacionais e clínicos que orientem para um critério único. Esta análise evidenciou a importância de uma padronização de métodos para detecção de sobrepeso e obesidade infantil, e que os procedimentos existentes devem ser utilizad...
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Pre-diabetes is recognized as an altered metabolic state, which precedes type 2 diabetes, and it is associated with great dysfunction of the intestinal microbiota, known as dysbiosis. Natural compounds, capable of reducing blood glucose... more
Pre-diabetes is recognized as an altered metabolic state, which precedes type 2 diabetes, and it is associated with great dysfunction of the intestinal microbiota, known as dysbiosis. Natural compounds, capable of reducing blood glucose without side effects and with a beneficial effect on the microbiota, have been studied as substitutes or adjuvants to conventional hypoglycemic agents, such as metformin. In this work, the effect of the nutraceutical Eriomin®, a mixture of citrus flavonoids (eriocitrin, hesperidin, naringin, and didymin), which reduces glycemia and increases glucagon-like peptide-1 (GLP-1) in pre-diabetic patients, was tested in the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), inoculated with pre-diabetic microbiota. After treatment with Eriomin® plus metformin, a significant increase in acetate and butyrate production was observed. Furthermore, sequencing of the 16S rRNA gene of the microorganisms showed that Eriomin® plus metformin stimulated the gro...
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In vivo antioxidant and anti-inflammatory effects of citrus flavanones.
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Polymethoxylated flavones (PMFs) have been associated with increased antioxidant activity in animal models. The effects of tangeretin (TAN) and nobiletin (NOB) on antioxidant activity in the blood and liver of rats were evaluated. Groups... more
Polymethoxylated flavones (PMFs) have been associated with increased antioxidant activity in animal models. The effects of tangeretin (TAN) and nobiletin (NOB) on antioxidant activity in the blood and liver of rats were evaluated. Groups of rats were treated with 200 mg/kg bw/day of TAN or NOB, or placebo, for 15 days. Parental compounds and their metabolites were assessed in the liver by chromatographic analysis, in addition to α-tocopherol and retinol in the blood serum. Both TAN and NOB supplements were able to reduce malonaldehyde (MDA) in the rat’s blood by 22% and 18%, respectively, but only NOB increased redox reaction by 3%. Blood levels of retinol and α-tocopherol increased under TAN by 59% and 20%, respectively, but were not affected by NOB. Eight NOB metabolites were detected in the liver, but only two TAN metabolites were identified in low concentration. In conclusion, NOB improved antioxidant capacity and reduced lipid peroxidation, while increased levels of retinol and...
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Page 1. PERFIL DE LIPIDES E LIPOPROTEINAS PLASMÁTICAS EM MULHERES SEDENTÁRIAS SUBMETIDAS A UM PROGRAMA DE ATIVIDADE FÍSICA* Ellen Cristini Faria ARAÚJO** Benedito Sérgio DENADAI*** Carlos ...
Page 1. NUTRITIONAL INTERACTIONS BETWEEN ZINC AND BRANCHED CHAIN AMINO ACID (BCAA) SUPPLEMENT IN RATS: A MULTICOMPARTMENT MODELING APPROACH* Jair Rodrigues GARCIA JÚNIOR*" Carlos ...
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A protein-free microemulsion (LDE) with a lipid composition resembling that of low-density lipoprotein (LDL) was used in metabolic studies in rats to compare LDE with the native lipoprotein. LDE labeled with radioactive lipids was... more
A protein-free microemulsion (LDE) with a lipid composition resembling that of low-density lipoprotein (LDL) was used in metabolic studies in rats to compare LDE with the native lipoprotein. LDE labeled with radioactive lipids was injected into the bloodstream of male Wistar rats, and plasma kinetics of the labeled lipids were followed on plasma samples collected at regular intervals for 12 h after injection. The 24-h LDE uptake by different tissues was also measured in tissue samples excised after the animals had been sacrificed. We found that LDE plasma kinetics were similar to those described for native LDL [fractional clearance rate (FCR) of cholesteryl ester, 0.42 +/- 0.11 h-1]. The major site for LDE uptake was the liver, and the tissue distribution of the LDE injected radioactivity was as one would expect for LDL. To test whether LDE was taken up by the specific LDL receptors, the LDE emulsion was injected into rats treated with 17 alpha-ethinylestradiol, which is known to increase the activity of these receptors; as expected, removal of LDE from the bloodstream increased (FCR = 0.90 +/- 0.35 h-1). On the other hand, saturation of the receptors that remove remnants by prior infusion of massive amounts of lymph chylomicrons did not change LDE plasma kinetics. These results indicate that LDE is cleared from plasma by B,E receptors and not by the E receptors that remove remnants. Incorporation of free cholesterol into LDE increased LDE plasma clearance. Incubation studies also showed that LDE incorporates a variety of apolipoproteins, including apo E, a ligand for recognition of lipoproteins by specific receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
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Research Interests: Oxidative Stress, Arterial hypertension, Medicine, Antioxidants, Kidney, and 15 moreBlood Pressure, Animals, Male, Heart rate, Catalase, Glutathione Peroxidase, American, NADPH oxidase, Clinical Sciences, Antioxidant enzyme, Ascorbic Acid, Rats, Biological markers, Baroreflex, and Mean Arterial Pressure
Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Faculdade de Ciencias Farmaceuticas de Araraquara (FCFAR), Departamento de Alimentos e Nutricao, Rodovia Araraquara - Jau, km 1, Quitandinha, CEP 14801902, Araraquara, SP,... more
Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Faculdade de Ciencias Farmaceuticas de Araraquara (FCFAR), Departamento de Alimentos e Nutricao, Rodovia Araraquara - Jau, km 1, Quitandinha, CEP 14801902, Araraquara, SP, Brasil
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LÍVIA GUSSONI BASILE1; THAÏS BORGES CESAR2 1Universidade Paulista (UNIP), Campus de São José do Rio Preto, Curso de Nutrição. Avenida Juscelino K. de Oliveira, s/n0, Jardim Tarraf II, CEP 15091-450, São José do Rio Preto, SP, Brasil.... more
LÍVIA GUSSONI BASILE1; THAÏS BORGES CESAR2 1Universidade Paulista (UNIP), Campus de São José do Rio Preto, Curso de Nutrição. Avenida Juscelino K. de Oliveira, s/n0, Jardim Tarraf II, CEP 15091-450, São José do Rio Preto, SP, Brasil. nutricao.riopreto@unip.br 2Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista Júlio de Mesquita Filho. Rodovia Araraquara-Jaú, Km 1, CEP 14801-902, Araraquara, SP, Brasil. tcesar@fcfar.unesp.br Este trabalho foi realizado no Departamento de Alimentos e Nutrição da Faculdade de Ciências Farmacêuticas da UNESP, Campus de Araraquara, SP. BASILE, L. G.; CESAR, T. B. Calcium and iron insufficiency in the meals of