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Excitation and ionization energies of unnatural nucleic acid bases: a computational approach
The nucleic acid bases in DNA and RNA are the basic units that encode all of genetic information. Researchers have tried to increase the number of...
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Complexes of Ionized Dipeptides of Glycyl-L-Glutamic Acid and Alanyl-L-Tyrosine with Nucleic Bases of the Pyrimidine Series
AbstractThe quantum chemical simulation of complexes of the glycyl-L-glutamic acid anion and the - alanyl-L-tyrosine Ala-L-Tyr zwitterion with...
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Artificial Modified Nucleotides for the Electrochemical Detection of Nucleic Acid Amplification Products
AbstractThe review describes the fundamental electrochemical properties of nucleic acids manifested on solid electrodes, with an emphasis on the...
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Anomalous Dissociative Capture Cross Section at the Interaction of Singly Charged Ions with Molecules of Nucleic Acid Bases
AbstractThe single electron capture process from adenine molecules by H + , 3 He + , N + , O + , and Ne + ions with an energy of 6.3 keV has been studied. It...
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Nucleic Acids: DNA and RNA
Nucleic acids are biomacromolecules that exist naturally in all the living organisms, and play fundamental roles in many biological processes such as...
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Nucleic Acids
Nucleic acids consist of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) which was first discovered by Friedrich Miescher in 1869. DNA are the...
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Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA
Protein–RNA and protein–DNA complexes play critical roles in biology. Despite considerable recent advances in protein structure prediction, the...
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Nucleic Acid Metabolism and Disorders
Nucleic acid metabolism refers to the entire spectrum of nucleotide synthesis and degradation activities. Anabolic mechanisms such as phosphate,...
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Sensing the structural and conformational properties of single-stranded nucleic acids using electrometry and molecular simulations
Inferring the 3D structure and conformation of disordered biomolecules, e.g., single stranded nucleic acids (ssNAs), remains challenging due to their...
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Bioinspired and bioengineered nucleic acid drug carriers
Nucleic acid drugs have great potential in treating various diseases due to their advantage of directly acting on disease-causing genes. However,...
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Detection, Structure and Polymorphism of Nucleic Acids
Detection and characterization of DNA and RNA is needed in many areas, which include all branches of biology, medicine, environmental control and...
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Understanding nucleic acid sensing and its therapeutic applications
Nucleic acid sensing is involved in viral infections, immune response-related diseases, and therapeutics. Based on the composition of nucleic acids,...
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Click Chemistry in Nucleic Acids
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction (known as Click Chemistry) has significantly impacted nucleic acid chemistry by...
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Nanosecond chain dynamics of single-stranded nucleic acids
The conformational dynamics of single-stranded nucleic acids are fundamental for nucleic acid folding and function. However, their elementary chain...
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Labeling and Detection of Modified Nucleic Acids
The nucleic acids were modified by various chemical groups to regulate gene expression without alteration of primary sequence. Until now, there are...
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CRISPR/Cas-mediated “one to more” lighting-up nucleic acid detection using aggregation-induced emission luminogens
CRISPR diagnostics are effective but suffer from low signal transduction efficiency, limited sensitivity, and poor stability due to their reliance on...
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PNBACE: an ensemble algorithm to predict the effects of mutations on protein-nucleic acid binding affinity
BackgroundMutations occurring in nucleic acids or proteins may affect the binding affinities of protein-nucleic acid interactions. Although many...
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Carbon Nanotubes and Nucleic Acids
Carbon materials have always held a very important position in materials research owing to their unique chemical structures, physiochemical...
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Pulmonary Delivery of Nucleic Acids
Pulmonary diseases affect millions of people worldwide and elicit symptoms that may evolve into severe conditions. Despite currently recommended...
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Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute
Argonaute (Ago) proteins mediate RNA- or DNA-guided inhibition of nucleic acids
1 ,2 . Although the mechanisms used by eukaryotic Ago proteins and long...