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Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine tumors (NET). Among the five...
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Combined anti-tumor efficacy of somatostatin fusion protein and vaccinia virus on tumor cells with high expression of somatostatin receptors
Somatostatin, a growth hormone-release inhibiting peptide, exerts antiproliferative and antiangiogenic effects on tumor cells. However, the short...
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Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states
Subtype 5 metabotropic glutamate receptors (mGlu 5 ) are known to play an important role in regulating cognitive, social and valence systems. However,...
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Plasticity in ligand recognition at somatostatin receptors
Somatostatin is a signaling peptide that plays a pivotal role in physiologic processes relating to metabolism and growth through its actions at...
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Molecular basis for the selective G protein signaling of somatostatin receptors
G protein-coupled receptors (GPCRs) modulate every aspect of physiological functions mainly through activating heterotrimeric G proteins. A majority...
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Somatostatin Receptor Analogs (68Ga-DOTATOC, 68Ga-DOTANOC, 68Ga-DOTATATE)
Neuroendocrine tumors (NETs) are rare neoplasms originating from neuroendocrine cells and characterized by the property of producing hormones and...
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Somatostatin-expressing interneurons modulate neocortical network through GABAb receptors in a synapse-specific manner
The firing activity of somatostatin-expressing inhibitory neurons (SST-INs) can suppress network activity via both GABAa and GABAb receptors (Rs)....
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Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors
The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great...
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Detection of acute myocarditis by ECG-triggered PET imaging of somatostatin receptors compared to cardiac magnetic resonance: preliminary results
AbstractSomatostatin receptors are overexpressed by inflammatory cells but not by cardiac cells, under normal conditions. This study assesses the...
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Theranostics with Somatostatin Receptor Antagonists
Somatostatin receptors (SST), especially SST subtype 2 (SST2), are important targets for the management of patients with neuroendocrine tumours...
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Structural insights into ligand recognition and selectivity of somatostatin receptors
Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple hormones such as growth hormone and thyroid-stimulating...
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M1 acetylcholine receptors in somatostatin interneurons contribute to GABAergic and glutamatergic plasticity in the mPFC and antidepressant-like responses
Alterations in glutamatergic and GABAergic function in the medial prefrontal cortex (mPFC) are prevalent in individuals with major depressive...
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Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a...
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Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish
BackgroundEnergy allocation between growth and reproduction determines puberty onset and fertility. In mammals, peripheral hormones such as leptin,...
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Somatostatin Analogs and Interferon in the Treatment of Neuroendocrine Tumors
The somatostatin analogs (SSAs) octreotide and lanreotide represent an important treatment for patients with metastatic well-differentiated...
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The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development
Glucose homeostasis is maintained by hormones secreted from different cell types of the pancreatic islets and controlled by manifold input including...
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Fish-hunting cone snail disrupts prey’s glucose homeostasis with weaponized mimetics of somatostatin and insulin
Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous,...
