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Tissue-Resident Macrophages Methods and Protocols
This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and...
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Physiology and diseases of tissue-resident macrophages
Embryo-derived tissue-resident macrophages are the first representatives of the haematopoietic lineage to emerge in metazoans. In mammals, resident...
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Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Remote organ injury, which is a common secondary complication of sterile tissue damage, is a major cause of poor prognosis and is difficult to...
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Elucidating Immune Monitoring of Tissue-Resident Macrophages by Intravital Microscopy
Intravital microscopy is an invaluable tool to study in real time the dynamic behavior of leukocytes in vivo. We describe herein a simple protocol...
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Sepsis-trained macrophages promote antitumoral tissue-resident T cells
Sepsis induces immune alterations, which last for months after the resolution of illness. The effect of this immunological reprogramming on the risk...
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Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway
ObjectiveResident immune cells are at the forefront of sensory organ-specific signals, and changes in these cells are closely related to the aging...
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The roles of tissue resident macrophages in health and cancer
As integral components of the immune microenvironment, tissue resident macrophages (TRMs) represent a self-renewing and long-lived cell population...
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Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis
Tissue-resident macrophages are critical for tissue homeostasis and repair. We previously showed that dermis-resident macrophages produce CCL24 which...
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Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection
Tissue-resident macrophage populations constitute a mosaic of phenotypes, yet how their metabolic states link to the range of phenotypes and...
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Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages
BackgroundTwo main subclasses of macrophages are found in almost all solid tissues: embryo-derived resident tissue macrophages and bone...
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Measuring the Metabolic State of Tissue-Resident Macrophages via SCENITH
Functional reprograming of cells is linked to a process of metabolic rewiring that is adapted for such new functions or microenvironment. Macrophages...
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Spectral Flow Cytometry Analysis of Resident Tissue Macrophages
Spectral flow cytometry improves flow cytometry panels by resolving the full emission spectra of individual fluorophores, allowing greater...
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Contribution of circulating monocytes in maintaining homeostasis of resident macrophages in postnatal and young adult mouse cochlea
The percentage of macrophage subpopulations based on their origins in the adult cochlea remains unclear. This study aimed to elucidate the origins of...
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Studying Efferocytosis Dynamics in Tissue-Resident Macrophages Ex Vivo
In vitro cocultures of macrophages and apoptotic cells (ACs) provide a practical and useful tool to study efferocytosis. Here, we describe a method...
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Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC
Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be phenotypically distinct from monocyte-derived macrophages....
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Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs
Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious functions. However, the potential function of virus-trained...
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Heterogeneity of adipose tissue-resident macrophages-beyond M1/M2 paradigm
Adipose tissue-resident macrophages (ATMs) are reported to be important for maintaining adipose tissue remodeling and homeostasis. ATMs were...
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Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression
Tissue-resident macrophages are derived from different precursor cells and display different phenotypes. Reconstitution of the tissue-resident...
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Transcriptomic profiling and regulatory pathways of cardiac resident macrophages in aging
Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs)...
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Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis
T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of...
