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A Positive/Negative Selection Cassette for Red Recombination of BAC Clones
AbstractConventional gene cloning methods always require tedious processes confined by PCR conditions and restriction sites, which might result in a...
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Turtle and tortoise mitogenomes under contrasting positive selection pressure
Testudinoidea represents an evolutionarily unique taxon comprising both turtles and tortoises. Turtles and tortoises are closely associated groups...
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Early positive spatial selection effects of beta-diversity on ecosystem functioning
ContextMetacommunity theory predicts that diversity arising at larger spatial scales (spatial β-diversity) may increase ecosystem functioning if...
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A dual-function selection system enables positive selection of multigene CRISPR mutants and negative selection of Cas9-free progeny in Arabidopsis
The CRISPR/Cas9 technology revolutionizes targeted gene knockout in diverse organisms including plants. However, screening edited alleles,...
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Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution
Knockout of the ORF8 protein has repeatedly spread through the global viral population during SARS-CoV-2 evolution. Here we use both regional and...
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Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations
BackgroundAdaptation to cold was essential for human migration across Eurasia. Non-shivering thermogenesis through brown adipose tissue (BAT)...
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Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels
Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure,...
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Identifying signatures of positive selection in human populations from North Africa
Because of its location, North Africa (NA) has witnessed continuous demographic movements with an impact on the genomes of present-day human...
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Positive Selection Screens for Programmable Endonuclease Activity Using I-SceI
Positive selection screens are high-throughput assays to characterize novel enzymes from environmental samples and enrich for more powerful variants...
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Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Malaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive...
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Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis
Human aging is marked by the emergence of a tapestry of clonal expansions in dividing tissues, particularly evident in blood as clonal hematopoiesis...
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Exploration on cold adaptation of Antarctic lichen via detection of positive selection genes
Lichen as mutualistic symbiosis is the dominant organism in various extreme terrestrial environment on Earth, however, the mechanisms of their...
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Robust model selection for positive and unlabeled learning with constraints
Positive and unlabeled (PU) learning is the problem in which training data contains only PU samples. Although PU learning is widely used in...
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Positive selection and functional diversification of transcription factor Cmr1 homologs in Alternaria
AbstractTranscription factor Cmr1 ( Colletotrichum melanin regulation 1) and its homologs in several plant fungal pathogens are the regulators of the...
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Signals of positive selection in genomes of palearctic Myotis-bats coexisting with a fungal pathogen
Disease can act as a driving force in shaping genetic makeup across populations, even species, if the impacts influence a particularly sensitive part...
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Genome-wide detection of positive and balancing signatures of selection shared by four domesticated rainbow trout populations (Oncorhynchus mykiss)
BackgroundEvolutionary processes leave footprints along the genome over time. Highly homozygous regions may correspond to positive selection of...
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Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer
BackgroundBreast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic...
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Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations
Selection on standing genetic variation is important for rapid local genetic adaptation when the environment changes. We report that, for the...
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Genetic characterization, structural analysis, and detection of positive selection in small heat shock proteins of Cypriniformes and Clupeiformes
In the current investigation, a total of 42 full-length, non-redundant small heat shock proteins (sHsp) were detected in Cyprinus carpio, Labeo...
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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer
Cancer gene discovery is reliant on distinguishing driver mutations from a multitude of passenger mutations in tumour genomes. While driver genes may...
