Search
Search Results
-
Relationship between ion currents and membrane capacitance in canine ventricular myocytes
Current density, the membrane current value divided by membrane capacitance (C m ), is widely used in cellular electrophysiology. Comparing current...
-
Single shot detection of alterations across multiple ionic currents from assimilation of cell membrane dynamics
The dysfunction of ion channels is a causative factor in a variety of neurological diseases, thereby defining the implicated channels as key drug...
-
Photolipid excitation triggers depolarizing optocapacitive currents and action potentials
Optically-induced changes in membrane capacitance may regulate neuronal activity without requiring genetic modifications. Previously, they mainly...
-
Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
Guanosine (GUO), widely considered a key signaling mediator, is implicated in the regulation of several cellular processes. While its interaction...
-
Ion currents through the voltage sensor domain of distinct families of proteins
The membrane potential of a cell (V m ) regulates several physiological processes. The voltage sensor domain (VSD) is a region that confers voltage...
-
CXCL10 Enhances Acid-Sensing Ion Channel Currents in Rat Dorsal Root
Both CXCL10/CXCR3 and acid-sensing ion channels (ASICs) are expressed in nociceptive sensory neurons and participate in various pain processes, but...
-
Afferent neurons of the kidney with impaired firing pattern in inflammation – role of sodium currents?
Peripheral neurons with renal afferents exhibit a predominantly tonic firing pattern of higher frequency that is reduced to low frequencies (phasic...
-
Characteristics of A-type voltage-gated K+ currents expressed on sour-sensing type III taste receptor cells in mice
Sour taste is detected by type III taste receptor cells that generate membrane depolarization with action potentials in response to HCl applied to...
-
PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents
Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) cells upon bladder distension attenuates spontaneous phasic...
-
Insulin enhances acid-sensing ion channel currents in rat primary sensory neurons
Insulin has been shown to modulate neuronal processes through insulin receptors. The ion channels located on neurons may be important targets for...
-
The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels
Proton-activated chloride (PAC) channels, ubiquitously expressed in tissues, regulate intracellular Cl - levels and cell death following acidosis....
-
Involvement of sodium–glucose cotransporter-1 activities in maintaining oscillatory Cl− currents from mouse submandibular acinar cells
In salivary acinar cells, cholinergic stimulation induces elevations of cytosolic [Ca 2+ ] i to activate the apical exit of Cl − through TMEM16A Cl − ...
-
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents
BackgroundAtomoxetine (ATX), a norepinephrine reuptake inhibitor (NRI), is used to attenuate the symptoms of Attention Deficit/Hyperactivity Disorder...
-
Activation of Animal Brain Neuromediators by Interferential Transcranial Currents
AbstractA method of transcranial electromagnetic stimulation of the mammalian brain is proposed. The method is based on the interference of currents...
-
Inhibition of the NMDA Currents by Probenecid in Amygdaloid Kindling Epilepsy Model
Epilepsy is characterized by a sustained depolarization and repeated discharge of neurons, attributed to overstimulation of N-methyl-D-aspartate...
-
Mechanically-Evoked TRPV4-Mediated Currents Are Modulated by Activated Integrin β1
TRPV4 is a polymodal, non-selective cation channel which can be activated by mechanical stimuli only when they are applied directly at the...
-
Analysing Mechanically Evoked Currents at Cell-Substrate Junctions
The precise study of mechanically activated ion channels requires a combination of electrophysiology to directly measure channel-mediated ionic flux...
-
Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Persistent sodium current (I NaP ) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of physiological...
-
Effect of Hibernation on Electrical Activity and Potassium Currents in the Myocardium of Long-Tailed Ground Squirrel
AbstractHibernating mammals are able to reduce their body temperature almost to 0°C. During this process, their heart is highly resistant to...
-
Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol
Cannabinol (CBN), an incompletely understood metabolite for ∆9-tetrahydrocannabinol, has been suggested as an analgesic. CBN interacts with...
