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The Atlantic Cod MHC I compartment has the properties needed for cross-presentation in the absence of MHC II
Atlantic cod has a peculiar immune system, characterized by the loss of Major Histocompatibility Complex (MHC) class II pathway, and an extreme...
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CapsNet-MHC predicts peptide-MHC class I binding based on capsule neural networks
The Major Histocompatibility Complex (MHC) binds to the derived peptides from pathogens to present them to killer T cells on the cell surface....
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Developing an erythrocyte‒MHC-I conjugate for cancer treatment
Mature erythrocytes are known to lack major histocompatibility complex (MHC) proteins. However, the presence of MHC molecules on erythrocytes has...
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MHCtools 1.5: Analysis of MHC Sequencing Data in R
The genes of the major histocompatibility complex (MHC) play a vital role in the vertebrate immune system and have attracted considerable interest in...
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MHC class II genotypes are independent predictors of anti-PD1 immunotherapy response in melanoma
BackgroundImmune checkpoint blockade is a highly successful anti-cancer immunotherapy. Both CTLA4 and PD1 checkpoint blockers are clinically...
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MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge
The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based...
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Reassessing human MHC-I genetic diversity in T cell studies
The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific...
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Uncovering novel MHC alleles from RNA-Seq data: expanding the spectrum of MHC class I alleles in sheep
BackgroundMajor histocompatibility complex (MHC) class I glycoproteins present selected peptides or antigens to CD8 + T cells that control the...
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Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation
Bats serve as reservoirs for numerous zoonotic viruses, yet they typically remain asymptomatic owing to their unique immune system. Of particular...
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Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response
Immunotherapy successfully complements traditional cancer treatment. However, primary and acquired resistance might limit efficacy. Reduced antigen...
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DiscovEpi: automated whole proteome MHC-I-epitope prediction and visualization
BackgroundAntigen presentation is a central step in initiating and shaping the adaptive immune response. To activate CD8 + T cells, pathogen-derived...
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Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression
Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the...
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Delineating Genetic Variability: Comparative Analysis of Yak MHC-DQB Gene through cDNA Cloning
AbstractNested within the vast genetic landscape of the major histocompatibility complex (MHC), a cluster of genes assumes a pivotal role in pathogen...
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Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas
Conservation genomics can greatly improve conservation outcomes of threatened populations, including those impacted by disease. Understanding...
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Antigen presentation by B cells enables epitope spreading across an MHC barrier
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which...
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Structure-aware deep model for MHC-II peptide binding affinity prediction
The prediction of major histocompatibility complex (MHC)-peptide binding affinity is an important branch in immune bioinformatics, especially helpful...
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MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses
Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic acid on host glycans as...
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ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I
Accumulating evidence supports the concept that DNA damage response targeted therapies can improve antitumor immune response by increasing the...
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Loss of heterozygosity impacts MHC expression on the immune microenvironment in CDK12-mutated prostate cancer
BackgroundIn prostate cancer (PCa), well-established biomarkers such as MSI status, TMB high, and PDL1 expression serve as reliable indicators for...
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Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I
BackgroundAlthough immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer treatment, only a minority of colorectal cancer...
