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RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
Purpose of ReviewThe maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...
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The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review
BackgroundHumans’ nervous system has a limited ability to repair nerve cells, which poses substantial challenges in treating injuries and diseases....
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Embryonic Stem Cell Protocols
This fully updated volume explores improved and extended protocols for embryonic stem cell (ESC) research, provided with the most direct and...
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MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner
H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles...
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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...
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Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
BackgroundStem cell therapy is a promising therapeutic strategy. In a previous study, we evaluated tumorigenicity by the stereotactic transplantation...
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Roles and Regulation of H3K4 Methylation During Mammalian Early Embryogenesis and Embryonic Stem Cell Differentiation
From generation of germ cells, fertilization, and throughout early mammalian embryonic development, the chromatin undergoes significant alterations...
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Effects of low doses of methylmercury (MeHg) exposure on definitive endoderm cell differentiation in human embryonic stem cells
Fetal development is one of the most sensitive windows to methylmercury (MeHg) toxicity. Laboratory and epidemiological studies have shown a...
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Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1
BackgroundUnderstanding the lineage differentiation of human prostate not only is crucial for basic research on human developmental biology but also...
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Crotonylation of GAPDH regulates human embryonic stem cell endodermal lineage differentiation and metabolic switch
BackgroundPost-translational modifications of proteins are crucial to the regulation of their activity and function. As a newly discovered acylation...
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Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects
The TET family is well known for active DNA demethylation and plays important roles in regulating transcription, the epigenome and development....
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MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4
ObjectiveVascular smooth muscle cell (VSMC) differentiation from stem cells is one source of the increasing number of VSMCs that are involved in...
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Fluorescent protein lifetimes report densities and phases of nuclear condensates during embryonic stem-cell differentiation
Fluorescent proteins (FP) are frequently used for studying proteins inside cells. In advanced fluorescence microscopy, FPs can report on additional...
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RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation
RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are involved in each step of RNA metabolism. Several RBPs are...
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miR-322 promotes the differentiation of embryonic stem cells into cardiomyocytes
Previous studies have shown that miR-322 regulates the functions of various stem cells. However, the role and mechanism of embryonic stem cell (ESCs)...
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DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables differentiation or self-renewal. Disruption of the stem state...
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Quiescence enables unrestricted cell fate in naive embryonic stem cells
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells...
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Regulatory role of apelin receptor signaling in migration and differentiation of mouse embryonic stem cell-derived mesoderm cells and mesenchymal stem/stromal cells
Mesoderm-derived cells, including bone, muscle, and mesenchymal stem/stromal cells (MSCs), constitute various parts of vertebrate body. Cell therapy...
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Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development
Astrocytes are resident glial cells of the central nervous system (CNS) that play complex and heterogeneous roles in brain development, homeostasis...
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Stem Cell Differentiation Mediated by Biomaterials/Surfaces
Directing the differentiation of stem cells into a specific stromal lineage such as adipocyte, chondrocyte, fibroblast, myocyte, and osteoblast cell...