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Target Hyperactive ERK Signaling for Cancer Therapy
Hyperactive ERK signaling has a well-defined role in cancer biology. Targeting this signaling node for cancer therapy has achieved promising outcomes...
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Plac8-ERK pathway modulation of monocyte function in sepsis
Sepsis, a life-threatening condition caused by infection, is characterized by the dysregulation of immune responses and activation of monocytes....
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The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis
BackgroundOvulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the...
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Emerging roles and mechanisms of ERK pathway mechanosensing
The coupling between mechanical forces and modulation of cell signalling pathways is essential for tissue plasticity and their adaptation to changing...
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Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop
BackgroundAfter diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may...
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Temporospatial inhibition of Erk signaling is required for lymphatic valve formation
Intraluminal lymphatic valves (LVs) and lymphovenous valves (LVVs) are critical to ensure the unidirectional flow of lymphatic fluid. Morphological...
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Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies
In vertical inhibition treatment strategies, multiple components of an intracellular pathway are simultaneously inhibited. Vertical inhibition of the...
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Low-frequency ERK and Akt activity dynamics are predictive of stochastic cell division events
Understanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is...
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ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework
At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp). Inhibitors targeting various effectors within the ERKp have...
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Electric field modulation of ERK dynamics shows dependency on waveform and timing
Different exogenous electric fields (EF) can guide cell migration, disrupt proliferation, and program cell development. Studies have shown that many...
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CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being...
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ERK mediates interferon gamma-induced melanoma cell death
BackgroundInterferon-gamma (IFNγ) exerts potent growth inhibitory effects on a wide range of cancer cells through unknown signaling pathways. We...
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The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
AKI induced by CP chemotherapy remains an obstacle during patient treatments. Extracellular signal-regulated protein kinases 1/2 (ERK), key...
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EPB41L3 Inhibits the Progression of Cervical Cancer Via the ERK/p38 MAPK Signaling Pathway
This study was aimed to uncover the character and potential regulatory mechanism of EPB41L3 in cervical cancer (CC). CC cells were injected into...
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Modulation effects of pressing manipulation on local inflammatory responses and ERK/NF-κB pathway in trigger point model rats
ObjectiveTo investigate the mechanism of trigger point deactivation induced by pressing manipulation in a rat model and to explore its potential...
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Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncogenic mutations leading to...
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RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa
During early development of the sea urchin embryo, activation of ERK signalling in mesodermal precursors is not triggered by extracellular RTK...
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Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury
The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection...
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PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway
BackgroundPatients with colorectal cancer (CRC) with liver metastasis or drug resistance have a poor prognosis. Previous research has demonstrated...
