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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues
RationaleWhen people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include...
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NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens
Powerful associations that link drugs of abuse with cues in the drug-paired environment often serve as prepotent relapse triggers. Drug-associated...
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Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner
Return to use, or relapse, is a major challenge in the treatment of opioid use disorder (OUD). Relapse can be precipitated by several factors,...
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Drug-related cues exacerbate deficits in delay discounting in individuals with heroin addiction
Although people with heroin addiction demonstrate impairment in delay discounting, no studies have explored the effects of drug-related cues on this...
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Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI
Addictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of...
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Enhanced conditioned “liking” of novel visual cues paired with alcohol or non-alcohol beverage container images among individuals at higher risk for alcohol use disorder
Rationale/ObjectiveThis study used an evaluative conditioning (EC) procedure to assess the affective properties of a CS for ingested drug reward in...
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Reinstatement of nicotine conditioned place preference in a transgenerational model of drug abuse vulnerability in psychosis: Impact of BDNF on the saliency of drug associations
RationalePsychotic disorders such as schizophrenia are often accompanied by high rates of cigarette smoking, reduced quit success, and high relapse...
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Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze...
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The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
RationaleRelapse into substance use is often triggered by exposure to drug-related environmental cues. The magnitude of drug seeking depends on the...
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Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs. A key...
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Estrous cycle dependent expression of oxycodone conditioned reward in rats
Oxycodone is one of the most widely prescribed and misused opioid painkillers in the United States. Evidence suggests that biological sex and...
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Use of the overexpectation effect to reduce conditioned seeking behavior controlled by nicotine
Nicotine produces robust stimulus effects that can be conditioned to form associations with reinforcing nondrug stimuli. We examine how established...
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Reinstatement of Pavlovian responses to alcohol cues by stress
RationaleStress may contribute to relapse to alcohol use in part by enhancing reactivity to cues previously paired with alcohol. Yet, standard models...
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The effects of passive and active administration of heroin, and associated conditioned stimuli, on consolidation of object memory
Mode of administration (i.e., active vs passive) could influence the modulatory action that drugs of abuse exert on memory consolidation. Similarly,...
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Role of dopamine D1 receptor in the modulation of memory consolidation by passive and self-administered heroin and associated conditioned stimuli
It has been proposed that opiates modulate memory consolidation, but recent work has indicated that this effect may be mediated by how the drug is...
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Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice
RationaleThe mammalian target of rapamycin (mTOR) kinase is known to mediate consolidation and reconsolidation of aversive memories. Most studies in...
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Blocking μ-opioid receptors attenuates reinstatement of responding to an alcohol-predictive conditioned stimulus through actions in the ventral hippocampus
The µ-opioid system is involved in the reinstatement of responding that is immediately evoked by alcohol-predictive cues. The extent of its...
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Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood
RationaleStress during childhood or adolescence increases vulnerability to psychiatric disorders in adults. In adult rodents, the delayed effects of...
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Cannabinoid use is enhanced by stress and changes conditioned stress responses
Individuals diagnosed with post-traumatic stress disorder (PTSD) are often comorbid for substance use disorders. Cannabis is widely used by PSTD...
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Goal-Directed and Habitual Control in Human Drug Addiction
Learning theory has proposed that everyday actions are controlled by at least two dissociable systems: one that governs deliberate goal-directed...