- ıstanbul
Cem Dane
Istinye University, Gynecology and Obstetrics, Faculty Member
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Research Interests: Medicine and Colposcopy
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Research Interests: Medicine and Gynecology
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Amac: Postmenopozal kanamalarda transvaginal ultrasonography (TVS) sonohisterografi ve histereskopinin tan› koymada yararl› olup olmad›¤›n›n araflt›r›lmas›. Gerec ve yontem: Prospektif olarak yap›lan bu cal›flmada 50 hastaya transvajinal... more
Amac: Postmenopozal kanamalarda transvaginal ultrasonography (TVS) sonohisterografi ve histereskopinin tan› koymada yararl› olup olmad›¤›n›n araflt›r›lmas›. Gerec ve yontem: Prospektif olarak yap›lan bu cal›flmada 50 hastaya transvajinal ultrasonografi, sonohisterografi ve histeroskopi uygulanm›flt›r. Tum tan›lar histeroskopi sonras›nda yap›lan biyopsi sonuclar›yla karfl›laflt›r›lm›flt›r. Bulgular: Tum endometrial lezyonlar gozonune al›nd›¤›nda endometriumda patoloji saptamada sensitivitesi TVS, sonohisterografi ve histeroskopi icin % 100, spesifisite TVS ve sonohisterografi icin % 76, histeroskopi icin % 100, TVS ve sonohisterografi icin % 89, histeroskopi icin % 100 bulunmufltur.
Research Interests: Medicine and Gynecology
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Research Interests: Medicine and Gynecology
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e Abstract—Spontaneous uterine rupture is a lifethreatening obstetrical emergency encountered infrequently in the Emergency Department. Emergency Physicians must consider this diagnosis when presented with a pregnant patient in shock with... more
e Abstract—Spontaneous uterine rupture is a lifethreatening obstetrical emergency encountered infrequently in the Emergency Department. Emergency Physicians must consider this diagnosis when presented with a pregnant patient in shock with abdominal pain. We present the case of a multigravid woman who had a spontaneous uterine rupture after induction with oxytocin, followed by a discussion of uterine rupture with special emphasis on the unscarred uterus. After the delivery, the patient was treated with fundal pressure and oxytocin due to severe vaginal hemorrhage. Despite the lack of vaginal hemorrhage after 1 h, the condition of the patient worsened. Laparotomy and a hysterectomy were performed. A parametrial hematoma about 20 cm was detected. The patient died 30 min after the operation. The treatment for intrapartum uterine rupture includes fluid resuscitation and emergency laparotomy. © 2009 Elsevier Inc.
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Research Interests: Medicine and Gynecology
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Although uterus and cervix infiltration is a frequent finding in the later stages of lymphomatous disease, non-Hodgkin's lymphoma (NHL) of the female genital tract is extremely rare. We present the case of a 63-years- old woman diagnosed... more
Although uterus and cervix infiltration is a frequent finding in the later stages of lymphomatous disease, non-Hodgkin's lymphoma (NHL) of the female genital tract is extremely rare. We present the case of a 63-years- old woman diagnosed with postmenopausal bleeding, Ann Arbor stage IE, primary, diffuse, large B-cell NHL of the uterus. Disease status was monitored with physical examination and imaging studies. We administered chemotherapy according to CHOP protocol (cyclophosphamide, adriamycin, vincristine, and prednisone). Primary pelvic NHL may present symptoms like other more common gynecologic cancers. It should be considered in the differential diagnosis of gynecologic malignancy. Our case emphasizes the importance of chemotherapy that can provide a control of the distant microscopic metastases.
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Objective: The aim of this study was to compare the histopathologic features and surgical stage of endometrial carcinoma with tumor-free endometrial tissues. Methods: Data from the files of 80 patients with endometrial carcinoma who were... more
Objective: The aim of this study was to compare the histopathologic features and surgical stage of endometrial carcinoma with tumor-free endometrial tissues. Methods: Data from the files of 80 patients with endometrial carcinoma who were managed at Haseki Training & Research Hospital between January 2001 and July 2007 were evaluated. We assessed tumor-free endometrium, stage, histologic type and grade, depth of myometrial invasion, peritoneal cytology, adnexal-cervical involvement, lymphovascular space invasion (LVSI), and lymph node metastases. Results: Twenty-nine patients (43%) with endometrial carcinoma had concomitant endometrial hyperplasia. Seven patients (10%) had one or more areas of metaplasia in the endometrium adjacent to the carcinoma. Endometrial carcinoma with atrophic background was significantly associated with aggressive histopathologic type (p < 0.04) and LVSI (p < 0.02). Conclusion: The histological characteristics of non-tumoral endometrium were found to be critical in determining the type of aggressive tumor and LVSI in atrophy-associated carcinomas.
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The aim of the present study was to compare the effects of raloxifene and low-dose hormone replacement therapy (HRT) on bone mineral density (BMD) and bone turnover markers in the treatment of postmenopausal osteoporosis. Forty-two... more
The aim of the present study was to compare the effects of raloxifene and low-dose hormone replacement therapy (HRT) on bone mineral density (BMD) and bone turnover markers in the treatment of postmenopausal osteoporosis. Forty-two postmenopausal osteoporotic women, who were randomized to receive raloxifene 60 mg or estradiol 1 mg/norethisterone acetate 0.5 mg daily for 1 year, were studied. All women received calcium 600 mg/day and vitamin D 400 IU/day. BMD and markers of bone turnover were measured at baseline and at 12 months. After 12 months of treatment, there were statistically significant increases in BMD in both groups at all sites (all p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). For the lumbar spine, the increase in BMD was 2.3% for raloxifene compared with 5.8% for low-dose HRT and corresponding values for total body BMD were 2.9% for raloxifene and 4.6% for low-dose HRT; the increases being significantly greater in the low-dose HRT group (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001 and p = 0.02, respectively). Although the increase in BMD at the hip was significant for both raloxifene (2.1%) and low-dose HRT (3.2%) compared with baseline, the difference between the two regimens did not reach statistical significance. The decrease in serum C-terminal telopeptide fragment of type I collagen and serum osteocalcin levels for the low-dose HRT group (-53% and -47%, respectively) was significantly greater than for the raloxifene group (-23% and -27%, respectively; both p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). In postmenopausal women with osteoporosis, low-dose HRT produced significantly greater increases in BMD of the lumbar spine and total body and greater decreases in bone turnover than raloxifene at 12 months.
Research Interests: Endocrinology, Medicine, Osteoporosis, Humans, Internal Medicine, and 15 moreLow Dose, Female, Bone Density, Peptides, Osteocalcin, Bone Mineral Density, Bone remodeling, Gynecological Diseases, Estradiol, Hormone Replacement Therapy, Raloxifene, Paediatrics and reproductive medicine, postmenopause, Collagen type I, and Drug combinations
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İleal Atrezinin Prenatal Ultrasonografik Tanısı Op.Dr. Cem DANE, Op.Dr. Banu DANE, Op.Dr. İbrahim TEMİZ, Op.Dr. Ahmet ÇETİN. ... Doğum sonrası yeşil renkli kusma ve batın distansiyonu olan bebekte tip II İleal atrezi (fibröz kord)... more
İleal Atrezinin Prenatal Ultrasonografik Tanısı Op.Dr. Cem DANE, Op.Dr. Banu DANE, Op.Dr. İbrahim TEMİZ, Op.Dr. Ahmet ÇETİN. ... Doğum sonrası yeşil renkli kusma ve batın distansiyonu olan bebekte tip II İleal atrezi (fibröz kord) saptanmıştır. ...
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Research Interests: Medicine and Gynecology
Research Interests: Medicine and Gynecology
Research Interests: Medicine and Gynecology
To compare the effects of the levonorgestrel-intrauterine system (LNG-IUS) and depot-medroxyprogesterone acetate (DMPA) on subendometrial vascularisation and uterine artery blood flow. The trial compared 25 patients wearing a LNG-IUS and... more
To compare the effects of the levonorgestrel-intrauterine system (LNG-IUS) and depot-medroxyprogesterone acetate (DMPA) on subendometrial vascularisation and uterine artery blood flow. The trial compared 25 patients wearing a LNG-IUS and 25 patients receiving DMPA. The subendometrial blood flow was evaluated using power Doppler analysis; the pulsatility index (PI) and resistance index (RI) in the uterine artery and spiral arteries were evaluated with spectral Doppler. The PI and RI of the uterine artery and endometrial thickness did not differ significantly between the two groups. The subendometrial vascularisation was lower and the PI in the spiral arteries was higher in DMPA-users. In spite of a similar prevalence of bleeding disturbances, the effects of DMPA and the LNG-IUS on the subendometrial microvascularisation differ.
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Research Interests: Physiology, Adolescent, Medicine, HUMAN PAPILLOMAVIRUS, Humans, and 15 moreCytology, Female, Polymerase Chain Reaction, Colposcopy, Clinical Sciences, Aged, Middle Aged, Adult, Cervical Intraepithelial Neoplasia, Early detection of cancer, Negative predictive value, Endocervical curettage, Papillomavirus Infections, mass Screening, and Papanicolaou test
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Research Interests: Medicine, Metabolic syndrome, Pregnancy, Humans, Internal Medicine, and 15 moreStandard Deviation, Blood Glucose, Preeclampsia, Female, Body Mass Index, Risk factors, Adult, Pregnant Women, Risk Factors, Gestational Age, Gestation, Gestational hypertension, Metabolic Syndrome X, Scoring system, and Paediatrics and reproductive medicine
The primary objective of the present study was to evaluate the effectiveness and adverse events of risedronate use in postmenopausal woman by measuring its effects on urinary crosslinked C-terminal telopeptides of type I collagen (CTx), a... more
The primary objective of the present study was to evaluate the effectiveness and adverse events of risedronate use in postmenopausal woman by measuring its effects on urinary crosslinked C-terminal telopeptides of type I collagen (CTx), a biochemical marker of bone resorption. One hundred osteoporotic (control and treatment) and 111 osteopenic (control and treatment) postmenopausal women, selected according to World Health Organization criteria, were included in the study. The treatment groups (osteopenic and osteoporotic) were given risedronate 35 mg once a week. The primary endpoint was mean percentage change in CTx from baseline to 6 months. The secondary endpoints included evaluation of the incidence of clinical or laboratory adverse events occurring during the 6-month study period. The least significant change (LSC), calculated from the within-subject variability in the two control groups, was used to define response. Of the 211 women enrolled, 157 (74.4%) completed the study. After 6 months, urinary CTx levels were -54.7% (range -67% to -48%) below baseline in the osteoporotic treatment group and -66.7% (range -74% to -59%) below baseline in the osteopenic treatment group. Analysis of LSC showed that 89% of risedronate treatment groups were categorized as responders after 6 months of treatment. The study shows that osteoporotic and osteopenic women on risedronate treatment have statistically significant suppressed bone turnover and CTx can be useful to confirm this observation. The low withdrawal rate and adverse effects rate show that risedronate was well tolerated by the study population.
Research Interests: Algorithms, Treatment Outcome, Medicine, Postmenopausal Women, Osteoporosis, and 14 moreHumans, Internal Medicine, Female, Peptides, Aged, Middle Aged, Biological markers, Osteopenia, Bone remodeling, Gynecological Diseases, Bone Resorption, Adverse effect, Paediatrics and reproductive medicine, and Collagen type I
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ABSTRACT Abstract In this study, we investigated whether the concentrations of pregnancy-associated plasma protein-A (PAPP-A) or free β-hCG (fβhCG) in the first trimester can identify women at increased risk of subsequent preterm delivery... more
ABSTRACT Abstract In this study, we investigated whether the concentrations of pregnancy-associated plasma protein-A (PAPP-A) or free β-hCG (fβhCG) in the first trimester can identify women at increased risk of subsequent preterm delivery in the absence of hypertensive disorders. Preterm and early preterm deliveries are defined as those deliveries before completing 37 and 34 weeks, respectively. A total of 868 women were enrolled into this study. According to the level of the markers, the patients were evaluated in three groups: 1 - maternal serum level ≤5th percentile, 2 - between 5th and 95th percentiles, 3 - ≥95th percentile. In the group of patients with a PAPP-A level ≤5th percentile [≤0.35 multiples of the median (MoM)], mean gestational age (GA) at delivery, mean birth weight and the number of the cases with early preterm delivery were significantly lower than the others. Mean level of PAPP-A was significantly lower in cases with early preterm than term deliveries (0.58 ± 0.32 versus1.09 ± 0.69; p = 0.01). Maternal serum level of fβhCG did not show significant difference between these groups (0.84 ± 0.45 versus 1.17 ± 0.77; p = 0.15). Low levels of maternal serum PAPP-A (≤0.35 MoM) (Odds ratio = 7; 95% confidence interval 1.8-27.7; p = 0.0048) significantly predicted early preterm delivery in normotensive pregnancies. Women with low levels of PAPP-A at first trimester have a higher risk of early preterm delivery even in the absence of hypertensive disorders.