Sedat AYDIN
Istanbul University, Istanbul Medical Faculty, Faculty Member
Introduction: Cisplatin is a well-known chemotherapeutic agent used in many cancer treatments. Several antioxidant agents are used for diminishing the toxic side effects of the cisplatin therapy. Alpha-lipoic acid (α-LA) and oxytocin (OT)... more
Introduction: Cisplatin is a well-known chemotherapeutic agent used in many cancer treatments. Several antioxidant agents are used for diminishing the toxic side effects of the cisplatin therapy. Alpha-lipoic acid (α-LA) and oxytocin (OT) are antioxidant agents that can be used in toxicity. Our aim is to investigate the effect of these antioxidants in cisplatin-induced ototoxicity in tissue level. Materials and Methods: Forty Wistar albino rats divided into five groups as control, cisplatin, cisplatin + intraperitoneal (IP) OT, cisplatin + intratympanic (IT) OT, and cisplatin + IT α-LA. The drug administration is applied for 4 days, and at the end of the procedure, the cochleas are harvested. After tissue preparation, GSTP1 levels are investigated and the intensity of the reaction is scored as negative (−), weak (1+), moderate (2+), or strong (3+). Results: Group 4 has a moderate staining which can be interpreted as high immunoreaction. When we compare with Group 1, this staining difference is statistically significant (P < 0.02). When we observe the Group 3, we cannot detect any difference with Group 1 in immunoreactivity. Conclusion: α-LA and OT are antioxidants effective against cisplatin ototoxicity. The expression of GSTP1 isozyme is increased in antioxidant-treated groups. Increased levels of these isozymes proved the increased healing response in tissue levels. Antioxidant agents can be used for adverse effects during cisplatin treatment. IT route is effective as IP systemic route.
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Bu çalışmada, parotis kaynaklı tümörlerin anatomik ve histopatolojik dağılımının yanı sıra tedavi yaklaşımın-dan elde ettiğimiz sonuçlar sunuldu. Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi 2. KBB kliniğinde 2001 ile 2008... more
Bu çalışmada, parotis kaynaklı tümörlerin anatomik ve histopatolojik dağılımının yanı sıra tedavi yaklaşımın-dan elde ettiğimiz sonuçlar sunuldu. Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi 2. KBB kliniğinde 2001 ile 2008 tarihleri arasında parotis cerrahisi uygulanan 52 hastanın kayıtları geriye dönük olarak gözden geçirildi. Yaş, cinsiyet, klinik belirti ve bulgular, histopatolojik tanı, komplikasyonlar, tümör evresi ve prognoz gibi bilgiler değerlendirildi. Yirmi üçü kadın, 29'u erkek yaş aralığı 15-77 arasında değişen, 52 parotis cerra-hisi uygulanan hastanın 6'sında kronik enflamatuvar hastalık 41'inde benign, 5'inde malign tümör mevcuttu. Malign tümörlü hastalara ve derin lob yerleşimli benign patolojiye sahip hastalara total, diğer hastalara yüze-yel parotidektomi uygulandı. Malign tümörlü hastalara ayrıca boyun diseksiyonu ve kemoradyoterapi gibi te-davi modaliteleri de eklendi. Tükrük bezi tümörlerinin ameliyat öncesi değerlendirilmesinde ince iğne...
Patients who underwent surgery for thyroid masses were evaluated with regard to clinical symptoms, diagnostic and treatment methods, and the results of treatment. The study included 92 patients (72 women, 20 men; mean age 45 years; range... more
Patients who underwent surgery for thyroid masses were evaluated with regard to clinical symptoms, diagnostic and treatment methods, and the results of treatment. The study included 92 patients (72 women, 20 men; mean age 45 years; range 16 to 71 years). Clinical diagnoses were based on findings of ultrasonography, thyroid function tests, thyroid scintigraphy, and fine-needle aspiration biopsy. Operations performed were near-total thyroidectomy (n=40), hemithyroidectomy (n=25), bilateral subtotal thyroidectomy (n=16), and total thyroidectomy (n=11). Patients with carcinoma associated with neck lymph node metastasis also underwent lateral, anterolateral, modified radical, or radical neck dissections. Postoperative histopathologic diagnoses were benign colloid nodule (n=70), papillary carcinoma (n=16), medullary carcinoma (n=2), anaplastic carcinoma (n=2), and Basedow-Graves disease (n=2). Unilateral vocal cord paralysis developed in 11 patients (11.9%), five of which persisted beyond...
Research Interests: Adolescent, Medicine, Thyroid, Humans, Thyroid gland, and 9 moreFemale, Male, Young Adult, Aged, Middle Aged, Adult, Thyroidectomy, Neck dissection, and Thyroid Neoplasms
The disease extention in nasal polyps was compared by using the mitotic activity rates and the computed tomography scores. This study was conducted on 19 nasal polyposis patients (8 males, 11 females; mean age 40.0+/-13.7 years; range 20... more
The disease extention in nasal polyps was compared by using the mitotic activity rates and the computed tomography scores. This study was conducted on 19 nasal polyposis patients (8 males, 11 females; mean age 40.0+/-13.7 years; range 20 to 63 years). The preoperative computed tomography records of the patients were evaluated according to the Lund-Mackay grading system. The polyp tissues of the same patients were stained with the Ki-67 antigen for immunohistochemical evaluation. The correlation between the radiologic results and the Ki-67 values was compared by means of the Spearman's correlation test. The mean computed tomography score was observed as 14.3+/-4.7 (range 7-24). The mean Ki-67 score resulting from the immunohistochemical staining was calculated as 24.3+/-18.5 (range 3.3-73.5%). A significant correlation was determined between the Ki-67 values and the computed tomography scores. ("Spearman's" correlation factor: 0.677; p<0.001). As the mitotic acti...
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Semento-ossifiye fibroma kemiğe benzeyen kalsifiye sementum dokusu ile fibröz dokuyu ya da her ikisini bir-den içeren selim fibro-ossöz bir lezyondur. Çoğunlukla mandibula ve maksillada görülür. Fakat nadiren etmo-id ve sfenoid sinüsü de... more
Semento-ossifiye fibroma kemiğe benzeyen kalsifiye sementum dokusu ile fibröz dokuyu ya da her ikisini bir-den içeren selim fibro-ossöz bir lezyondur. Çoğunlukla mandibula ve maksillada görülür. Fakat nadiren etmo-id ve sfenoid sinüsü de tutabilir. Sekiz yaşındaki kız çocuğu olan olgumuzda 3 aydır devam eden horlama, bu-run tıkanıklığı ve burun akıntısı şikayetleri mevcuttu. Fizik muayene de nazal kavitenin sol tarafını dolduran sert, büyük bir kitle izlendi. Manyetik rezonans görüntülemede sol etmoid ve sfenoid sinüste, düzgün sınırlı, yuvarlak, 55x40x50 mm boyutunda kitle saptandı. İntrakraniyal yayılımından dolayı tümör anterior transba-zal ve transnazal endoskopik yaklaşım ile çıkarıldı. Histopatolojik tanısı semento-ossifiye fibrom olarak geldi. Anahtar Sözcükler: Etmoid sinüs; kemik tümörleri; paranazal sinüs tümörleri; semento-ossifiye fibrom; sfenoid sinüs. Cemento-ossifying fibroma is a benign fibroosseous lesion that contains fibrous tissue and calcified tissue resembling ...
A thirty-five-year-old woman had an asymptomatic, slow growing mass that pushed the right tonsilla palatina and was pulsatile in the oropharyngeal region. Magnetic resonance imaging showed a vascular mass at the carotid bifurcation,... more
A thirty-five-year-old woman had an asymptomatic, slow growing mass that pushed the right tonsilla palatina and was pulsatile in the oropharyngeal region. Magnetic resonance imaging showed a vascular mass at the carotid bifurcation, causing displacement of the external and internal carotid arteries. The diagnosis of a carotid body tumor was confirmed by magnetic resonance angiography. Surgery included a subadventitial dissection at the carotid bifurcation, preserving the hypoglossal and vagal nerves. The patient developed loss of function of the tenth cranial nerve postoperatively. After a year follow-up period, there was no change in the function of the tenth cranial nerve.
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Correction of microstomia is often maintained by conventional surgical methods which require a long process and high surgical skills [1]. With the “Fishtail” technique, it was observed that the intercommissural distance and... more
Correction of microstomia is often maintained by conventional surgical methods which require a long process and high surgical skills [1]. With the “Fishtail” technique, it was observed that the intercommissural distance and interincisaldistance could be increased by more than 10 mm and 5 mm, respectively, while preserving the specific structure of the mouth commissure [2]. According to conventional surgical techniques, the “fishtail” technique is aesthetically and functionally acceptable, cheap and practical.
Head-and-neck region tumors are mostly seen on the larynx. The risk factors of this region may increase the secondary tumors. Nasal squamous cell carcinoma (SCC) can be detected after larynx SCCs, a second primary tumor. Second primary... more
Head-and-neck region tumors are mostly seen on the larynx. The risk factors of this region may increase the secondary tumors. Nasal squamous cell carcinoma (SCC) can be detected after larynx SCCs, a second primary tumor. Second primary tumors are difficult to manage. Total rhinectomy is the choice of treatment modality, but rehabilitation is necessary. We present a secondary nasal SCC treated with total rhinectomy. A 67-year-old patient, who was treated for larynx SCC by total laryngectomy 3 years ago, was admitted to the outpatient clinic with a complaint of nasal swelling and pain. The patient was diagnosed as nasal SCC. Total rhinectomy was performed, and silicon nasal prosthesis was applied after 3 months of surgery. Total rhinectomy can be rehabilitated via silicon nasal prosthesis. This was cost-effective, safe, less time-consuming, and functional. Using prosthesis has given us better chance to detect recurrences. We encourage surgeons to use prosthesis for rehabilitation.
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Abstract Cervical lymphangiomas are benign congenital malformations of lymphatic system usually seen in children under 2 years of age. It is rare in adults. They can be seen in any part of the body but the most common area in the neck... more
Abstract Cervical lymphangiomas are benign congenital malformations of lymphatic system usually seen in children under 2 years of age. It is rare in adults. They can be seen in any part of the body but the most common area in the neck region is posterior triangle. They usually present as asymptomatic masses. There are various ways of treatment, but the most common treatment modality is surgical resection. Here, the authors present a giant lymphangioma in the neck region of an adult who is treated with surgical resection without any complication.
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A 66-year-old man presented with progressive unilateral nasal obstruction. He had noted worsening left nasal blockage for several months, which was abruptly relieved with the expression of a polypoid mass during a sneeze. He froze the... more
A 66-year-old man presented with progressive unilateral nasal obstruction. He had noted worsening left nasal blockage for several months, which was abruptly relieved with the expression of a polypoid mass during a sneeze. He froze the specimen in plastic wrap and made an otolaryngology appointment. He was evaluated 1 week later. Physical examination revealed a healthy appearing man with no obvious nasal obstruction. Results of the ENT examination, including nasal endoscopy, were normal. The polypoid tissue brought by the patient was sent for pathologic evaluation, which revealed adenoid cystic carcinoma. A repeat nasal endoscopy revealed a left posterior septal lesion just anterior to the choana and opposite the middle turbinate (Fig 1). Magnetic resonance imaging did not show any cranial nerve or brain involvement. The patient was taken to the operating room. An endoscopic biopsy of the lesion visualized in the office confirmed a diagnosis of adenoid cystic carcinoma, and the lesion and posterior septum were resected. The margins were controlled by frozen section. The patient was discharged on the same day and at 9 months has no evidence of disease.
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İdiopatik Tolosa-Hunt sendromu (İTHS) tek taraflı orbital ağrı, ipsilateral okülomotor sinir paralizisi ve ste-roidlere hızlı yanıtla kendini gösteren çok nadir rastlanılan ağrılı oftalmopleji sebebidir. Süperior orbital fis-sür veya... more
İdiopatik Tolosa-Hunt sendromu (İTHS) tek taraflı orbital ağrı, ipsilateral okülomotor sinir paralizisi ve ste-roidlere hızlı yanıtla kendini gösteren çok nadir rastlanılan ağrılı oftalmopleji sebebidir. Süperior orbital fis-sür veya kavernöz sinüste yerleşen granülamatöz lezyon sebebiyle bu sendrom kraniyal sinir paralizilerine yol açar. Bu yazıda, fasiyal sinir paralizisi gelişmiş İTHS olgusu literatür bilgileri gözden geçirilerek sunuldu. Anahtar Sözcükler: Fasiyal sinir paralizisi; idiopatik Tolosa-Hunt sendromu; oftalmopleji. Idiopathic Tolosa-Hunt syndrome (ITHS) is a very rare cause of painful ophthalmoplegia characterized by unilateral orbital pain, ipsilateral oculomotor paralysis and prompt response to steroids. It gives rise to cranial nerve paralysis due to a granulomatous lesion in the cavernous sinus or superior orbital fissure. We report herein a case of ITHS with facial nerve palsy together with a review of the literature.
Objective: To analyze the exposure of the jugular foramen afforded by the fallopian bridge technique. Method: The jugular foramen exposure was obtained using the jugular foramen approach combined with the fallopian bridge technique. We... more
Objective: To analyze the exposure of the jugular foramen afforded by the fallopian bridge technique. Method: The jugular foramen exposure was obtained using the jugular foramen approach combined with the fallopian bridge technique. We applied this technique using 10 temporal bone specimens at a tertiary referral center. The exposure was assessed by means of depth of the dissection field and two separate dissection spaces that were created anteriorly and posteriorly to the facial nerve. Anteroposterior and superoinferior dimensions of the anterior dissection space were 4.4 1.03 mm and 6.3 2.49 mm, respectively. The superoinferior and anteropos-terior dimensions of the posterior dissection space were 11.7 2.08 mm and 8.0 2.95 mm, respectively. The depth of the first dissection field was 8.2 2.11 mm. After perforating the jugular bulb, the depth of the second dissection field was 16.0 1.60 mm. Results: The anterior dissection space serves only as an additional visualization space for ...
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OBJECTIVES We investigated the relationship between the size of concha bullosa (CB) detected by coronal paranasal sinus computed tomography (CT) and the frequency of sinonasal symptoms. PATIENTS AND METHODS The study included 60 patients... more
OBJECTIVES We investigated the relationship between the size of concha bullosa (CB) detected by coronal paranasal sinus computed tomography (CT) and the frequency of sinonasal symptoms. PATIENTS AND METHODS The study included 60 patients (39 females, 21 males; mean age 38.3 years; range 17 to 67 years) who had CB on CT scans and underwent endoscopic sinus surgery for symptoms of chronic sinusitis, nasal obstruction and/or headache. The patients were evaluated in three groups according to the ratio of the cross-section area of CB to that of the nasal cavity (NC); hence, group 1, 0-14%; group 2, 15-29%; and group 3, = or >30%. The relationship of CB/NC with clinical symptoms and nasal pathologies were examined. RESULTS The presenting complaints were sinusitis in 28 (46.7%), nasal obstruction in 56 (93.3%), and headache in 36 (60%) patients. Concha bullosa was on the right side in 16 (26.7%), on the left side in 13 (21.7%), and bilateral in 31 patients (51.7%). Of 91 CB, 29 (31.9%) ...
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We present a patient that had a frontal sinus mucocele, which was the result of a traffic accident that occurred 3 years earlier. During surgery via the osteoplastic approach we observed glass particles in the left frontal sinus. As... more
We present a patient that had a frontal sinus mucocele, which was the result of a traffic accident that occurred 3 years earlier. During surgery via the osteoplastic approach we observed glass particles in the left frontal sinus. As patients with foreign bodies in the paranasal sinus are not commonly seen in otolaryngological practice, especially glass particles in the frontal sinus, and papers dealing with this issue are rare in the English language literature, we present our case and a review of the literature.
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This retrospective, population-based study reviewed skin prick test (SPT) results against various allergens of 1,552 patients with allergic rhinitis (AR) in the district of Kartal, Istanbul, Turkey. The skin prick tests yielded a positive... more
This retrospective, population-based study reviewed skin prick test (SPT) results against various allergens of 1,552 patients with allergic rhinitis (AR) in the district of Kartal, Istanbul, Turkey. The skin prick tests yielded a positive result in 946 patients (60.9%). Seven hundred and forty-give (48%) patients had perennial AR, 558 (36%) perennial AR with seasonal exacerbations and 249 (16%) had seasonal AR. The prevalence of AR was highest in the age of 21-40 years with 48.7%. The allergen group with the highest SPT positivity was pollens at 44.3%, followed by molds at 38.4%, mites at 35.1%, and epithelia-insect at 30.8%. The strongest single allergen was Altemaria altemata with 33.3%, followed by Dermatophagoides farinae with 29.3%, Dermatophagoides pteronyssinus with 25.3% and a mix of four cereals (barley, maize, oat, wheat) with 25.2%. This information will help etiological research as well as the development of more efficient treatment plans for patients with allergic rhini...
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OBJECTIVES The aim of this study was to compare the usefulness of nasal smear eosinophilia with skin prick test for the diagnosis of allergic rhinitis and to determine the degree of correlation between the tests. PATIENTS AND METHODS... more
OBJECTIVES The aim of this study was to compare the usefulness of nasal smear eosinophilia with skin prick test for the diagnosis of allergic rhinitis and to determine the degree of correlation between the tests. PATIENTS AND METHODS Forty-one patients (16 males, 25 females; mean age 35.17; range 14 to 56 years) with a clinical history suggestive of nasal allergy and fifteen controls (7 males, 8 females; mean age 27.6; range 16 to 40 years) without any history of allergy were enrolled in this study. Skin sensitivity tests were applied in both groups. Nasal smear was examined by light microscopy. RESULTS A positive skin test reaction was demonstrated in 73.2% of the study group and in 20% of the controls, whereas 73.2% of the patients and 13.3% of the controls demonstrated significant nasal smear eosinophilia. There was 25.5% correlation between the skin prick test and nasal smear eosinophilia, although this was not statistically significant. CONCLUSION Both the skin prick test and n...
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OBJECTIVES To reveal microscopic surgical anatomy of the middle ear in guinea pigs (GPs). MATERIALS AND METHODS Twenty ears of GPs were dissected under dissection microscopy via inferior approach. By using digital equipment, the most... more
OBJECTIVES To reveal microscopic surgical anatomy of the middle ear in guinea pigs (GPs). MATERIALS AND METHODS Twenty ears of GPs were dissected under dissection microscopy via inferior approach. By using digital equipment, the most suitable photograph was taken for each step. Differences and similarities between the ears of GPs and those of human beings are discussed to show the advantages and disadvantages of the GP ear for experimental studies. RESULTS Tympanic membrane of the GP merely consists of pars tensa and above this there is a bony segment called as supratympanic crest. There were two spaces called bulla and hypotympanium in the GP,s middle ear. Cochlea, which is normally found in the inner ear in humans, separates these two spaces. Upper part of this space which is called epitympanium is a slit like cavity having a bony complex called malleoincudal complex. Bulla, the largest cavity in the middle ear, is a hemispherical cavity having a smooth surface. It corresponds to ...
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Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma. Its most frequent location is the parotid gland. It usually appears as a firm and mobile slow-growing mass. Histologically, isomorphic cells in nests... more
Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma. Its most frequent location is the parotid gland. It usually appears as a firm and mobile slow-growing mass. Histologically, isomorphic cells in nests and ...
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Mucocele is benign, slow-growing, mucous-filled cystic lesions that arise in the paranasal sinuses. It causes progressive distension of the bony walls and induces compressive symptoms. Surgical treatment of paranasal sinus mucoceles... more
Mucocele is benign, slow-growing, mucous-filled cystic lesions that arise in the paranasal sinuses. It causes progressive distension of the bony walls and induces compressive symptoms. Surgical treatment of paranasal sinus mucoceles includes endoscopic approach or external approach. The authors report a patient of frontal mucocele who presented with a history of progressive unilateral protrusion. Computed tomography scan revealed a large mucocele of the frontal sinus with orbital extension on the same side. He was successfully treated with endoscopic marsupialization without any serious complications.
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Introduction Noise-induced hearing loss (NIHL), which is one of the most common occupational diseases among industrialized populations, is associated with longstanding exposure to high levels of noise. The pathogenesis of NIHL is not... more
Introduction Noise-induced hearing loss (NIHL), which is one of the most common occupational diseases among industrialized populations, is associated with longstanding exposure to high levels of noise. The pathogenesis of NIHL is not clear, but some genes and their activity at the tissue level have been investigated. Hypercholesterolemia, which can disturb the microcirculation, can be one of the underlying pathologies in hearing loss. Objective To investigate the relationship between NIHL and hypercholesterolemia. Methods The study group was selected among workers who had an occupational exposure of 85 dB of noise for at least 10 years. The audiologic assessment was recorded at seven frequencies (500 Hz, 1,000 Hz, 2,000 Hz, 3,000 Hz, 4,000 Hz, 6,000 Hz and 8,000 Hz). A total of 456 workers were included in the study and divided into two groups: the control group (252 patients) and the NIHL group (204 patients). After the audiologic measurement, blood samples were taken and investiga...
Non Hodgkin lymphomas correspond to 25 % of all head and neck cancers. These rare tumors only include less than 5 % of malign tumors in parotid region. Differential diagnosis of these tumors cover many malign and benign tumors of the... more
Non Hodgkin lymphomas correspond to 25 % of all head and neck cancers. These rare tumors only include less than 5 % of malign tumors in parotid region. Differential diagnosis of these tumors cover many malign and benign tumors of the parotid gland. Definite diagnosis depends on sufficient tissue material of parotidectomy specimen. Treatment modality is surgical removal of the lesion with or without additional radiation and chemotherapy depending on the stage of the tumor. Prognosis is better than other forms of the B-cell lymphoma. We present a 54 year old woman who suffered from progressively and slowly growing mass on parotid region, without any inflammatory disease or chronic infection, diagnosed with mucosa associated lymphoid tissue lymphoma of the parotid gland. Parotid gland was totally excised by superficial parotidectomy and there is no recurrence after 5 years postoperative period.
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Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during... more
Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during pregnancy, has antioxidant and antiinflammatory effect. Our study aims to test and compare the effect of intratympanic (IT) and intraperitoneal (IP) oxytocin on cisplatin ototoxicity with DPOAE. A total of 24 Wistar albino rats were randomly divided into four groups: Group 1 received 0.1-0.3 ml IT saline + IP saline solutions for 4 days (n = 6), Group 2 received cumulative dose of 20 mg/kg IP cisplatin divided into two equal doses in first and second days of experiment + 0.1-0.3 ml IT saline for 4 days, Group 3 received same dose of cisplatin as Group 2 + 0.1-0.3 ml IT oxytocin for 4 days, and Group 4 received same dose of cisplatin as Groups 2 and 3 + IP oxytocin with dose of 1 mg/kg. DPOAE was performed prior to procedure and at the end of the experiment on day 5. Group 2 showed severe ototoxic effect of cisplatin according to DPOAE result (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). When compared with Group 2, DPOAE amplitude reductions were smaller in Group 3 (3.2, 3.8, 4.5, 6.3 and 7.6 kHz) (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05) and Group 4 which is statistically significant in 5.4, 6.3 and 7.6 kHz (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). When Group 3 and Group 4 were compared, reductions were smaller in 2.7 and 3.2 kHz in Group 3 (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). In this study, we showed the protective effect of IT and IP oxytocin on cisplatin ototoxicity. We suggest oxytocin in cisplatin ototoxicity, especially via IT route even with high-dose cisplatin.
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Dermoid and epidermoid cysts are rare cysts of the head and neck region, which should be considered in differential diagnosis of sublingual mass, constituting 0.01 % of all oral cavity cysts. There are suspected theories regarding the... more
Dermoid and epidermoid cysts are rare cysts of the head and neck region, which should be considered in differential diagnosis of sublingual mass, constituting 0.01 % of all oral cavity cysts. There are suspected theories regarding the basis of the pathology. 30-year-old male referred to our clinic with a chief complaint of sublingual mass which had been present for many years but the lesion enlarged over the past 3 years. MRI examination revealed a giant cystic mass which was 3.6 × 3.9 mm in diameter and medially located at sublingual region. Intraoral approach was preferred for surgery and no recurrence or complaints were detected during follow-up period. When a cystic mass is detected on the floor of oral cavity, we must consider dermoid cysts for differential diagnosis. Surgery is the only treatment. If possible, intraoral approach should be preferred because of its perfect cosmetic results.
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Aim: To compare the protective effect of dexamethasone and lactate against cisplatin-induced ototoxicity. Materials and methods: Thirty Wistar rats were randomly divided into 4 groups. After the rats were sedated with intraperitoneal (IP)... more
Aim: To compare the protective effect of dexamethasone and lactate against cisplatin-induced ototoxicity. Materials and methods: Thirty Wistar rats were randomly divided into 4 groups. After the rats were sedated with intraperitoneal (IP) ketamine hydrochloride (50 mg/kg) and xylazine (7.5 mg/kg), baseline ABRs (auditory brainstem evoked responses) were measured in response to clicks and tone pips of 4, 8, 12, and 16 kHz. After auditory thresholds were determined, the animals received drug administration as follows: Group 1 (n: 6) received intratympanic (IT) saline (0.9% NaCl) solution, Group 2 (n: 8) IP cisplatin (20 mg/kg) alone, Group 3 (n: 8) IT dexamethasone (0.1-0.3 mL), and Group 4 (n: 8) IT lactated Ringer's (LR) solution (0.1-0.3 mL) followed after 30 min by 20 mg/kg cisplatin. Dexamethasone, LR solution, and saline application were continued for 3 days. At the end of the study, ABR testing was performed and threshold changes were recorded. Results: Group 2 animals show...
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Anthracotic pigmentation in the bronchial mucosa is a bronchoscopic finding of pneumoconiosis, or evidence of heavy atmospheric soot. This pigmentation in the tracheobronchial mucosa is surrounded by calcified or noncalcified lymph nodes.... more
Anthracotic pigmentation in the bronchial mucosa is a bronchoscopic finding of pneumoconiosis, or evidence of heavy atmospheric soot. This pigmentation in the tracheobronchial mucosa is surrounded by calcified or noncalcified lymph nodes. Anthracosis is not a previously known cause of left vocal fold paralysis. We present what we believe to be the first reported case of anthracosis-caused vocal fold paralysis.
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To evaluate the protective effect of betahistine on noise-induced hearing loss (NIHL) using scanning electron microscopy (SEM) and distortion product otoacoustic emission (DPOAE). A total of 8 adult albino guinea pigs were used in this... more
To evaluate the protective effect of betahistine on noise-induced hearing loss (NIHL) using scanning electron microscopy (SEM) and distortion product otoacoustic emission (DPOAE). A total of 8 adult albino guinea pigs were used in this study (study group: n=4 and control group: n=4). DPOAE measurements of both groups were performed before the procedure. Two hours before noise exposure, 0.9% NaCl solution was injected perorally to the control group and betahistine was administered through a peroral catheter to the study group. Both groups were then exposed to 105-dB sound pressure level (SPL) 4-kHz frequency-based narrow-band noise for 2 h per day for 5 days. DPOAE measurements were performed again on the 6th day and cochleae were dissected and examined by SEM on the 7(th) day. Regarding the results of DPOAE, NIHL was observed in both groups on the 6th day (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). Loss, flattening, and fusion, which are findings of permanent hearing loss, were determined in the stereocilia of the inner and outer hair cells by SEM. These findings were evaluated as signs of permanent increase in the threshold. When DPOAE measurements and SEM results were evaluated in the study group, no significant difference was observed in NIHL compared with the control group (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05). In our study, it was observed that simultaneous administration of betahistine during noise had no protective effect on permanent increase in the threshold. However, further studies on noise and long-term use of betahistine can be performed.
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Lymphangioma is a congenital malformation of the lymphatic system, which is located mostly on the head and neck region. Most of the cases are seen at age younger 2 years. It is rare in adult population and when detected, it can be treated... more
Lymphangioma is a congenital malformation of the lymphatic system, which is located mostly on the head and neck region. Most of the cases are seen at age younger 2 years. It is rare in adult population and when detected, it can be treated with surgical excision. We present a 50-year-old patient with giant lymphangioma on the posterior cervical region of the neck treated by surgical treatment successfully.
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This retrospective, population-based study reviewed skin prick test (SPT) results against various allergens of 1,552 patients with allergic rhinitis (AR) in the district of Kartal, Istanbul, Turkey. The skin prick tests yielded a positive... more
This retrospective, population-based study reviewed skin prick test (SPT) results against various allergens of 1,552 patients with allergic rhinitis (AR) in the district of Kartal, Istanbul, Turkey. The skin prick tests yielded a positive result in 946 patients (60.9%). Seven hundred and forty-give (48%) patients had perennial AR, 558 (36%) perennial AR with seasonal exacerbations and 249 (16%) had seasonal AR. The prevalence of AR was highest in the age of 21-40 years with 48.7%. The allergen group with the highest SPT positivity was pollens at 44.3%, followed by molds at 38.4%, mites at 35.1%, and epithelia-insect at 30.8%. The strongest single allergen was Altemaria altemata with 33.3%, followed by Dermatophagoides farinae with 29.3%, Dermatophagoides pteronyssinus with 25.3% and a mix of four cereals (barley, maize, oat, wheat) with 25.2%. This information will help etiological research as well as the development of more efficient treatment plans for patients with allergic rhini...
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Granular cell tumors are benign subcutaneous or submucosal lesions of neurogenic origin. In this case study one patient was diagnosed and treated successfully with complete surgical resection of a laryngeal granular cell tumor that was... more
Granular cell tumors are benign subcutaneous or submucosal lesions of neurogenic origin. In this case study one patient was diagnosed and treated successfully with complete surgical resection of a laryngeal granular cell tumor that was originated from the left arytenoid region that very rare location. There is no evidence of recurrence 2 years after surgery. Granular cell tumors should be considered in the differential diagnosis of laryngeal masses, particularly in the posterior glottis.
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Tuberculosis, which is one of the oldest diseases of the human kind, is again becoming an important health issue in recent years. Although mostly seen in lungs, it can also be localized in the lymph nodes, skin, meninges, spleen, surrenal... more
Tuberculosis, which is one of the oldest diseases of the human kind, is again becoming an important health issue in recent years. Although mostly seen in lungs, it can also be localized in the lymph nodes, skin, meninges, spleen, surrenal tissues, which is referred to as extrapulmonary forms of tuberculosis. Tuberculous lymphadenitis is the most common clinical form of extrapulmonary tuberculosis and it is generally localized in cervical lymph nodes. A 50-year-old female patient presented with a hard fixed mass originating from medial canthus ending at nasolabial sulcus. In the magnetic resonance imaging examination, a solid contrast enhancing mass 20 x 18 x 15 mm in size, which was isointensely monitored with muscular structures in T1 based visuals and hyperintense in T2 sequences, was seen. The mass was excised under general anesthesia and histopathological examination revealed tuberculous lymphadenitis. Thus, the case is discussed according to literature and shows us that tubercu...
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The disease extention in nasal polyps was compared by using the mitotic activity rates and the computed tomography scores. This study was conducted on 19 nasal polyposis patients (8 males, 11 females; mean age 40.0+/-13.7 years; range 20... more
The disease extention in nasal polyps was compared by using the mitotic activity rates and the computed tomography scores. This study was conducted on 19 nasal polyposis patients (8 males, 11 females; mean age 40.0+/-13.7 years; range 20 to 63 years). The preoperative computed tomography records of the patients were evaluated according to the Lund-Mackay grading system. The polyp tissues of the same patients were stained with the Ki-67 antigen for immunohistochemical evaluation. The correlation between the radiologic results and the Ki-67 values was compared by means of the Spearman's correlation test. The mean computed tomography score was observed as 14.3+/-4.7 (range 7-24). The mean Ki-67 score resulting from the immunohistochemical staining was calculated as 24.3+/-18.5 (range 3.3-73.5%). A significant correlation was determined between the Ki-67 values and the computed tomography scores. ("Spearman's" correlation factor: 0.677; p<0.001). As the mitotic acti...
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Patients who underwent surgery for thyroid masses were evaluated with regard to clinical symptoms, diagnostic and treatment methods, and the results of treatment. The study included 92 patients (72 women, 20 men; mean age 45 years; range... more
Patients who underwent surgery for thyroid masses were evaluated with regard to clinical symptoms, diagnostic and treatment methods, and the results of treatment. The study included 92 patients (72 women, 20 men; mean age 45 years; range 16 to 71 years). Clinical diagnoses were based on findings of ultrasonography, thyroid function tests, thyroid scintigraphy, and fine-needle aspiration biopsy. Operations performed were near-total thyroidectomy (n=40), hemithyroidectomy (n=25), bilateral subtotal thyroidectomy (n=16), and total thyroidectomy (n=11). Patients with carcinoma associated with neck lymph node metastasis also underwent lateral, anterolateral, modified radical, or radical neck dissections. Postoperative histopathologic diagnoses were benign colloid nodule (n=70), papillary carcinoma (n=16), medullary carcinoma (n=2), anaplastic carcinoma (n=2), and Basedow-Graves disease (n=2). Unilateral vocal cord paralysis developed in 11 patients (11.9%), five of which persisted beyond...