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A case of twin pregnancy with one normal fetus coexisting with a complete molar placenta is presented. The clinical presentation and complications are described. The role of color flow mapping in reaching a correct diagnosis is highlighted.
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The aim was to see the effect of pregnancy on Bone Mineral Density (BMD) and bone turnover markers (BTMs) in the immediate postpartum period and 12 months thereafter. Eighty women delivered at KAUH (May 2009-Oct 2010) had BMD, bone... more
The aim was to see the effect of pregnancy on Bone Mineral Density (BMD) and bone turnover markers (BTMs) in the immediate postpartum period and 12 months thereafter. Eighty women delivered at KAUH (May 2009-Oct 2010) had BMD, bone profile, 25-OH vitamin D and (BTMs). Inclusion criteria: Singleton pregnancy without medical or pregnancy complications. Exclusion criteria: multiple pregnancies, history of diabetes thyroid or bone disease, and use of any medication that affect calcium metabolism. Biochemical tests were repeated for 27 women after one year. Statistical analysis was done using SPSS 16. Eighty women had BMD before discharge. Sixty four women (80%) had low BMD; sixteen of these (25%) had osteoporosis. Although bone profiles were normal, Vitamin D levels were moderately or severely deficient in 35.37% of women. After adjustment for BMI and age there was no correlation between BMD and other variables. Multiple linear regressions showed that BMI was the predictor for BMD (P=0....
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The relationship between glycated haemoglobin (an index of long-term diabetic control), fructosamine (an index of intermediate-term diabetic control), and serum IgA, IgG, and IgM was studied in 110 diabetic patients (41 Type 1 and 69 Type... more
The relationship between glycated haemoglobin (an index of long-term diabetic control), fructosamine (an index of intermediate-term diabetic control), and serum IgA, IgG, and IgM was studied in 110 diabetic patients (41 Type 1 and 69 Type 2) and compared with 111 healthy non-diabetic subjects. Significant increases in serum IgA (by 82.7%, p < 0.001) and IgG (by 35.2%, p < 0.001) concentrations were observed whereas the concentration of IgM was significantly decreased (by 46.7%, p < 0.001) in diabetic patients compared with non-diabetic subjects. Using Spearman's rank correlations, IgA correlated with fructosamine (r = 0.77, p < 0.001), HbA1 (r = 0.76, p < 0.001), and albumin (r = -0.58, p < 0.001) for the entire population sample but only fructosamine (r = 0.19, p < 0.05) and HbA1 (r = 0.28, p < 0.001) correlated with IgA in diabetic patients, respectively. It is concluded that abnormal levels of IgA, IgG, and IgM are very common in diabetic patients in whom serum IgA concentrations are influenced by the degree of glycaemic control. Whether changes in IgA and other immunoglobulins are implicated in the pathogenesis of diabetic complications (such as susceptibility to infection) deserve further study.
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Fetal plasma ferritin concentrations were measured in 43 normal fetuses at 18-36 weeks and in 78 blood samples collected before transfusion from 23 fetuses with Rh alloimmunization. Among controls, there was a significant correlation... more
Fetal plasma ferritin concentrations were measured in 43 normal fetuses at 18-36 weeks and in 78 blood samples collected before transfusion from 23 fetuses with Rh alloimmunization. Among controls, there was a significant correlation between fetal serum ferritin and gestational age (r = 0.39, P = .009), consistent with an increase in fetal storage of iron during normal pregnancy. In Rh-alloimmunized fetuses, the ferritin concentration was above the reference range in 63% of the samples. Before the first transfusion, the fetal ferritin concentration was increased compared with controls (mean multiples of the mean = 2.6, range 1-26) and showed a negative correlation with fetal hematocrit (r = -0.43, P less than .05), suggesting that the worse the fetal anemia, the higher the iron store. Serial transfusions were associated with further increase in serum ferritin, which correlated primarily with the total volume of blood transfused. Three fetuses had plasma serum ferritin concentrations...
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Objective: To investigate the iron status of pregnant Saudi Women living in the Jeddah area. Design: The iron status was assessed by measuring haematological parameters (haemoglobin, haematocrit, mean corpuscular volume and mean... more
Objective: To investigate the iron status of pregnant Saudi Women living in the Jeddah area. Design: The iron status was assessed by measuring haematological parameters (haemoglobin, haematocrit, mean corpuscular volume and mean corpuscular haemoglobin) and biochemical parameters (serum ferritin, serum iron, total iron binding capacity and transferrin saturation). Setting: Al-Shati Hospital, Jeddah, Saudi Arabia. Subjects: 119 pregnant women were introduced into the study when they were at 20-24 weeks of gestation (mid-pregnancy). Of these, 72 women were followed up at late pregnancy (36-40 weeks). Results: The mean serum ferritin level at mid pregnancy was 17.3 ± 1.8 ng/ml which was not significantly different from that at late pregnancy (17.9 ± 2.0 ng/ml)
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Full text is available as a scanned copy of the original print version.
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To evaluate urinary iodine excretion during the course of pregnancy and postpartum in relation to maternal and neonatal thyroid function parameters in Saudi women living in Jeddah, Kingdom of Saudi Arabia. A prospective longitudinal study... more
To evaluate urinary iodine excretion during the course of pregnancy and postpartum in relation to maternal and neonatal thyroid function parameters in Saudi women living in Jeddah, Kingdom of Saudi Arabia. A prospective longitudinal study was conducted on Saudi normal pregnant women during the course of pregnancy (N=80), at term and 6-10 weeks postpartum (N=65), during the period January 1997 through to December 2000. Maternal urinary iodine excretion was determined together with serum levels of total thyroxine, total tri-iodothyronine, free thyroxine, free tri-iodothyronine, thyrotropin, reverse tri-iodothyronine, thyroxine-binding globulin and thyroglobulin. A group of non-pregnant woman (N=200) were included for comparative purposes. Data were also analyzed for significant trends using ANOVA. Neonatal serum levels of total thyroxine, total tri-iodothyronine, free thyroxine, thyrotropin, thyroxine-binding globulin, and thyroglobulin were also measured. Changes in urinary iodine ex...
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To evaluate the relative importance of thyroid hormones and human chorionic gonadotropin in relation to the risk of gestational thyrotoxicosis in Saudi women living in Jeddah, Kingdom of Saudi Arabia. A prospective study was conducted on... more
To evaluate the relative importance of thyroid hormones and human chorionic gonadotropin in relation to the risk of gestational thyrotoxicosis in Saudi women living in Jeddah, Kingdom of Saudi Arabia. A prospective study was conducted on Saudi healthy pregnant women (N=406) at 12-15 weeks of gestation and compared with healthy non-pregnant controls (N=200). Maternal serum levels of free thyroxine free triiodothyronine, thyrotropin, human chorionic gonadotropin and free b-human chorionic gonadotropin together with urinary iodine excretion were determined. Analysis of variance was used to examine differences among the groups for different variables and the Bonferroni criterion was used when significance tests were made. Pregnant women were classified into 2 groups according to the lower limit of serum thyrotropin levels in non-pregnant euthyroid controls at >= 0.3 mIU/L (Group one) or < 0.30 mIU/L (Group 2). Suppressed levels of serum thyrotropin (< 0.30 mIU/L) were found in ...
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A case of hydrops fetalis caused by massive fetomaternal hemorrhage was initially successfully treated by intrauterine intravascular transfusion. Unexplained intrauterine death occurred 2 weeks afterwards. The investigation of... more
A case of hydrops fetalis caused by massive fetomaternal hemorrhage was initially successfully treated by intrauterine intravascular transfusion. Unexplained intrauterine death occurred 2 weeks afterwards. The investigation of fetomaternal hemorrhage by fetal blood sampling and the management are discussed.
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C-peptide, insulin, and glucagon levels were measured in the cord blood of 112 nondiabetics controls and 63 diabetic mothers. The cord blood levels of insulin and C-peptide were significantly higher in the diabetic compared to the control... more
C-peptide, insulin, and glucagon levels were measured in the cord blood of 112 nondiabetics controls and 63 diabetic mothers. The cord blood levels of insulin and C-peptide were significantly higher in the diabetic compared to the control group. In the ...
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Research Interests: Complementary and Alternative Medicine, Plant Biology, Ethnopharmacology, Pregnancy, Mice, and 12 moreNicotine, Female, Animals, Clinical Sciences, Infant Mortality, Sex Factors, Time Factors, Fetal death, Litter Size, postpartum period, Paediatrics and reproductive medicine, and Pharmacology and pharmaceutical sciences
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Research Interests: Research Methodology, Primary Health Care, Data Analysis, Reproduction, Anthropometry, and 15 moreDeveloping Countries, Health, Biometry, Medicine, Pregnancy, Population, Humans, Femur, Female, Abdominal Circumference, Head, Fetus, Gestational Age, Reference Values, and Paediatrics and reproductive medicine
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We report a rare case of Meckel-Gruber syndrome in a woman who had three affected offsprings in the past with similar condition. Ante-natal ultrasonographic diagnosis and management are presented.
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Research Interests: Birth Weight, Prospective studies, Pregnancy, Humans, Renin Angiotensin Aldosterone System, and 15 moreFemale, Regression Analysis, Enzyme, Longitudinal Studies, Human reproduction, Adult, Longitudinal Study, Angiotensin II, Prospective Study, Creatinine, Intrauterine Growth Restriction, Pre Eclampsia, Rate Limiting, angiotensinogen, and Medical and Health Sciences
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OBJECTIVES: To evaluate calcium-regulating hormones and parathyroid hormone-related peptide (PTHrP) in normal human pregnancy and postpartum in women not deficient in vitamin D. DESIGN: A prospective longitudinal study was conducted in... more
OBJECTIVES: To evaluate calcium-regulating hormones and parathyroid hormone-related peptide (PTHrP) in normal human pregnancy and postpartum in women not deficient in vitamin D. DESIGN: A prospective longitudinal study was conducted in pregnant Saudi women during the course of pregnancy (n = 40), at term and 6 weeks postpartum (n = 18). Maternal concentrations of serum calcidiol and calcitriol were determined, together with those of serum intact-parathyroid hormone (PTH), PTHrP, calcitonin, osteocalcin, human placental lactogen (hPL), prolactin, vitamin D binding protein, alkaline phosphatase, calcium, phosphate and magnesium. A group of non-pregnant women (n = 280) were included for comparative purposes. RESULTS: The calcidiol concentrations decreased (mean +/- S.D.) significantly from 54 +/- 10 nmol/l in the first trimester to 33 +/- 8 nmol/l in the third trimester (P…
Research Interests: Calcium, Pregnancy, Humans, Prolactin, Magnesium, and 15 moreFemale, Hormones, Osteocalcin, Parathyroid Hormone, Calcitriol, Alkaline phosphatase, Clinical Sciences, Calcium Phosphate, Longitudinal Studies, Parathyroid Hormone Related Protein, Adult, Longitudinal Study, Mammary gland, postpartum period, and Paediatrics and reproductive medicine
In order to define a level of &quot;pathological hyperglycaemia&#39;, i.e. glucose intolerance that predicts perinatal morbidity among the obstetric population, 100 g glucose tolerance tests (GTTs) were performed in 660 patients... more
In order to define a level of &quot;pathological hyperglycaemia&#39;, i.e. glucose intolerance that predicts perinatal morbidity among the obstetric population, 100 g glucose tolerance tests (GTTs) were performed in 660 patients attending for antenatal care at the University Hospital in Jeddah. The results were analysed in two ways: (1) patients were stratified according to the number of abnormal glucose values on the GTTs and (2) patients were placed into one of three groups according to the 100 g GTT diagnostic criteria, i.e. normal (non-GDM), abnormal with fasting blood glucose (FBG) &gt; or = 5.8 mmol l-1 (GDM), and abnormal with FBG &lt; 5.8 mmol l-1 (gestational induced hyperglycaemia, GIH). Although there was a stepwise association between fetal/maternal morbidity with increasing number of abnormal glucose values, no level of glucose intolerance could be defined as a threshold level for normal response. However, when stratified by FBG, GDM patients were significantly heavier (78.5 kg +/- SD 14.9), had a higher incidence of both macrosomia (27.5%) and operative delivery (25.3%) than the other two groups (14.7%, 14.3%, and 15.4%, 12.8% in the non-GDM and GIH, respectively). It is suggested that among patients with abnormal GTT results a FBG &gt; or = 5.8 mmol l-1 identifies a threshold for true &quot;pathological hyperglycaemia&#39;.
Research Interests: Birth Weight, Gestational diabetes, Pregnancy, Humans, Hyperglycemia, and 15 moreBlood Glucose, Female, Regression Analysis, Clinical Sciences, Risk Factor, Adult, Morbidity, Analysis of Variance, Retrospective Studies, Cesarean Section, Risk Factors, Gestational Age, Glucose Tolerance Test, Gestation, and High risk
One hundred and twelve fetuses with structural anomalies (n = 84), intrauterine growth retardation (n = 21) or amniotic fluid volume disorders (n = 7) detected by ultrasound underwent blood sampling from the intrahepatic vein for rapid... more
One hundred and twelve fetuses with structural anomalies (n = 84), intrauterine growth retardation (n = 21) or amniotic fluid volume disorders (n = 7) detected by ultrasound underwent blood sampling from the intrahepatic vein for rapid karyotyping. The procedure was successful in 95.5%. 12.5% of the fetuses had an abnormal karyotype. Fetal bradycardia was observed in two fetuses (1.8%) and intraperitoneal bleeding in three (2.7%). There were three procedure-related losses but these were not due to the intrahepatic vein sampling itself. Fetal blood sampling is the method of choice for rapid karyotyping in the second and third trimesters, and the intrahepatic vein is an alternate site when access is difficult or failure to sample occurs at the placental cord insertion. Additional advantages of fetal blood sampling at the intrahepatic vein include absence of cord complications, reduced risk of fetal blood loss and fetomaternal haemorrhage, and the lack of need to confirm the fetal origin of the sample.