... SIPHONELLINOL, A NEW TRITERPENE FROM THE MARINE SPONGE SIPHONOCHALINA SIPHONELLA Shmuel Carmelya, Yosi Loyab and Yoe] Kashmana* Departments of ... and notes 1. Y. Kashman, A. Groweiss, S. Carmely, Z. Kinamoni, D. Czarkie and M. Rotem,... more
... SIPHONELLINOL, A NEW TRITERPENE FROM THE MARINE SPONGE SIPHONOCHALINA SIPHONELLA Shmuel Carmelya, Yosi Loyab and Yoe] Kashmana* Departments of ... and notes 1. Y. Kashman, A. Groweiss, S. Carmely, Z. Kinamoni, D. Czarkie and M. Rotem, Pure & ...
Research Interests:
Alzheimer's disease (AD) is the most prevalent cause of dementia in adults. Current available drugs for AD transiently alleviate some of the symptoms, but do not modify the disease mechanism or cure it. Therefore, new drugs are... more
Alzheimer's disease (AD) is the most prevalent cause of dementia in adults. Current available drugs for AD transiently alleviate some of the symptoms, but do not modify the disease mechanism or cure it. Therefore, new drugs are desperately needed. Key contributors to AD are amyloid beta (Aβ)- and reactive oxygen species (ROS)-induced cytotoxicities. Plant-derived substances have been shown to affect various potential targets in various diseases including AD. Therefore, phytochemicals which can protect neuronal cells against these insults might help in preventing and treating this disease. In the following research, we have isolated the sesquiterpene lactone achillolide A from the plant Achillea fragrantissima and, for the first time, characterized its effects on Aβ-treated neuroblastoma cells. Aβ is a peptide derived from the sequential cleavage of amyloid precursor protein, and is part of the pathogenesis of AD. Our current study aimed to determine whether achillolide A can int...
Research Interests:
Research Interests:
Oxidative stress is tightly involved in various neurodegenerative diseases such as Parkinson's and Alzheimer's diseases, and conditions such as ischemia. Astrocytes, the most abundant glial cells in the brain, protect neurons from... more
Oxidative stress is tightly involved in various neurodegenerative diseases such as Parkinson's and Alzheimer's diseases, and conditions such as ischemia. Astrocytes, the most abundant glial cells in the brain, protect neurons from reactive oxygen species (ROS) and provide them with trophic support. Therefore, any damage to astrocytes will affect neuronal survival. In a previous study we have demonstrated that an extract prepared from the plant Achillea fragrantissima (Af) prevented the oxidative stress-induced death of astrocytes and attenuated the intracellular accumulation of ROS in astrocytes under oxidative stress. In the present study, using activity guided fractionation, we have purified from this plant the active compound, determined to be a flavonoid named 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (TTF). The effects of TTF in any biological system have not been studied previously, and this is the first study to characterize the anti-oxidant and protective ef...
Research Interests: Complementary and Alternative Medicine, Biology, Neurochemistry, Cell Biology, Oxidative Stress, and 15 moreMedicine, Reactive Oxygen Species, Animals, Cytoprotection, Astrocytes, Kinase, Hydrogen Peroxide, Plant extracts, Rats, Flavones, Cell Survival, Neurosciences, Intracellular, Achillea, and Medical biochemistry and metabolomics
Research Interests: Biochemistry, Hematology, Developmental Biology, Cancer, Biology, and 15 moreCell Cycle, Drug Discovery, Hypoxia, Cell Biology, Infectious Diseases, Cancer Research, Apoptosis, Chronic Myeloid Leukaemia, Drug Resistance, Imatinib, Hypoxia targeted cancer therapy, Chronic myeloid leukemia, Leukemia stem cells, Biochemistry and cell biology, and Imatinib Mesylate
Research Interests: Organic Chemistry, Biology, Cell Biology, Oxidative Stress, Medicine, and 15 moreReactive Oxygen Species, Animals, Astrocytes, Sesquiterpenes, Hydrogen Peroxide, Molecules, Plant extracts, Rats, Cell Survival, Lactones, Viability assay, Neuroprotective Agents, Intracellular, Achillea, and Achillolide A
Marine sponges and corals are widely recognized as rich sources of novel bioactive natural products. These organisms are frequently colonized by bacteria. Some of these bacteria can be pathogenic or serve as beneficial symbionts.... more
Marine sponges and corals are widely recognized as rich sources of novel bioactive natural products. These organisms are frequently colonized by bacteria. Some of these bacteria can be pathogenic or serve as beneficial symbionts. Therefore, these organisms need to regulate the bacteria they encounter and resist microbial pathogens. One method is by chemical defense. Antimicrobial assays performed with extracts of 23 Red Sea corals and sponges against bacteria isolated from their natural environment revealed considerable variability in antimicrobial activity. Soft corals exhibited appreciable activity; sponges showed variability, and stony corals had little or no activity. Among the soft corals, Xenia macrospiculata exhibited the highest activity. Bioassay-directed fractionation of the extract indicated that the activity was due to a range of compounds, one of which was isolated and identified as the diterpene desoxyhavannahine. Among the sponges, Amphimedon chloros exhibited strong ...