SAMIR K MANDAL
Did his BSc and MSc from Burdwan University. After short Industrial training at Dabur Pharma Ltd. did his PhD from IACS Kolkata in 2009. He visited USA for PostDoctoral Research. He enjoyed teaching in PDWC for 3 years. Currently he is an Assistant Professor at Saldiha College. He has completed DST Start Up Research Grant from the Saldiha College in 2017.
Phone: +91 9433356499
Address: Department of Chemistry,
Saldiha College
Saldiha, Bankura- 722173
Phone: +91 9433356499
Address: Department of Chemistry,
Saldiha College
Saldiha, Bankura- 722173
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Papers by SAMIR K MANDAL
Since the discovery of the valuable effects of fluorine insertion into organic molecules, the synthesis and application of organofluorine compounds underwent an evolution in recent years. The main cause of such developments was the pharmaceutical industry; although, organofluorine compounds are widely applied in many other applications like agrochemicals to household. Being unavailability of natural fluorinated compounds, chemical synthesis is highly demanding. Modified Julia-Kociensky reaction is one of such important protocol to be considered for synthesis of fluorinated building blocks like fluoro-vinyl organic compounds.
Introduction of fluorine can lead to either increase or decrease in the efficacy of a compound depending on its mode of action, physicochemical properties, target interaction, or metabolic vulnerability and transformation. The goal of this protocol is to provide an exciting research field, as broad as possible, highlighting recent developments in the design and synthesis of fluorine compounds."
Dr. Samir Kumar Mandal
Department of Chemistry, P. D. Women’s College, NBU, Jalpaiguri
E-mail: samirmandal2004@gmail.com
The scientific and commercial awareness of fluorinated compound largely grew after the need to replace industrial chlofluorocarbons (CFC) by hydrofluorocarbon (HFC). Active ingredients having fluorine substitution turn into an important idea in the quest for recent crop protection with optimal efficacy, environmental safety, user friendliness, and economic viability. Recent growth of fluorinated commercials is expected to replace non-fluorinated halogen commercials.
Introduction of fluorine can lead to either an increase or a decrease in the efficacy of a compound depending on its mode of action, physicochemical properties, target interaction, or metabolic vulnerability and transformation. Still research is on its way to find the exact sites in a molecule at which fluorine substitution will result in optimal desired effects.
Dr. Samir Kumar Mandal
Department of Chemistry, P. D. Women’s College, NBU, Jalpaiguri, INDIA-735101
Fluorinated compounds are highly important as they are potential enzyme inhibitors, anti-carcinogenic agents, and anti-oestrogenic agents. Fluorine can modify the biological activity by altering the physicochemical properties due to its high electronegetivity and small size. Being unavailability of natural fluorinated compounds, chemical synthesis is highly demanding. Modified Julia-Kociensky reaction is one of such important protocol to be considered for synthesis of fluorinated building blocks.
Dr Samir Kumar Mandal
Department of Chemistry, P. D. Women’s College, NBU, Jalpaiguri
Incorporation of fluorine into organic molecules changes the conformation of a molecule. Besides absolute configuration of the diol epoxide, conformation of the tetrahydro ring has also been suggested to be at least partially responsible for mutagenic activity. So, role of conformation in biological activity can be evaluated from site specifically modified DNA of 6-Fluorobenzo[a]pyrene [6-FBaP] metabolite. 6-FBaP and its significant metabolites, the dihydrodiol and diol epoxides, have been synthesized and structurally characterized, and the extent of modified nucleoside by the metabolites has been assessed. Asymmetric synthesis of nucleoside adduct of the metabolites were completed which is crucial for characterization of the diastereoselective synthesis.
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Dr Samir Kumar Mandal
Department of Chemistry, City College of CUNY, New York, USA
Part I: Incorporation of fluorine into organic molecules changes the conformation of a molecule. Besides absolute configuration of the diol epoxide, conformation of the tetrahydro ring has also been suggested to be at least partially responsible for mutagenic activity. So, role of conformation in biological activity can be evaluated from site specifically modified DNA of 6-Fluorobenzo[a]pyrene [6-FBaP] metabolite. 6-FBaP and its significant metabolites, the dihydrodiol and diol epoxides, have been synthesized and structurally characterized, and the extent of modified nucleoside by the metabolites has been assessed. Asymmetric synthesis of nucleoside adduct of the metabolites were completed which is crucial for characterization of the diastereoselective synthesis.
Part II: Fluoro-alkenes are of much current interest in the field of biological science as well as material science. Fluoro-alkenes compounds are also key synthons for various organic synthetic transformations. Modified Julia-Kociensky reaction is an important protocol for the synthesis of fluoro-alkene under very mild condition.