Zingiber officinale is one of the most commonly used spices. We developed a method to determine the main pungent ginger constituents, 6-, 8- and 10-gingerols and 6-shogaol in human plasma. Quantitation was achieved using a reversed-phase... more
Zingiber officinale is one of the most commonly used spices. We developed a method to determine the main pungent ginger constituents, 6-, 8- and 10-gingerols and 6-shogaol in human plasma. Quantitation was achieved using a reversed-phase C(18) column using high-performance liquid chromatography with electrochemical detection. The assay was linear from 0.1 to 5.0 μg/mL. The within-day coefficients of variation for the assay at 5.0 μg/mL were ≤ 5% for all analytes. The recovery of all four analytes was ≥99% for at 5.0 μg/mL. The lower limit of quantitation was 0.1 μg/mL except for 10-gingerol which was 0.25 μg/mL. Currently, there is no analytical method for detecting pungent ginger constituents in human plasma. This HPLC method allows for the detection of all four of ginger's pungent constituents simultaneously in a relatively short run time of 25 minutes. This method should be useful for determining plasma levels of 6-, 8-, 10-gingerol and 6-shogaol in phase I clinical trials.
Research Interests:
There are few data on the prevalence and pattern of complementary and alternative medicine (CAM) supplement use among people with chronic heart failure (CHF). The aim of this survey was to characterize the prevalence, pattern, and reasons... more
There are few data on the prevalence and pattern of complementary and alternative medicine (CAM) supplement use among people with chronic heart failure (CHF). The aim of this survey was to characterize the prevalence, pattern, and reasons for use of CAM supplements among those with CHF. We conducted a cross-sectional survey in 2 groups: CHF patients who had participated in the Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) Trial, and CHF patients who attended the University of Michigan's CHF Outpatient Clinic. We received 252 surveys. One third of respondents had used a CAM supplement in the last 6 months. There were 24 different supplements used. Reasons for use included heart problems, anxiety, weight loss, and arthritis. No demographic or behavioral characteristic identified CAM supplement users, although a 50% lower use among HERB CHF participants approached statistical significance (P = .08). One third of our CHF patients were taking CAM supplements, s...
Research Interests:
Research Interests: Humans, Female, Male, Supportive Care, Randomised Controlled Trial, and 15 moreNausea, Aged, Prevalence, Middle Aged, Adult, Randomized Controlled Trial, Adverse Event, Combination drug therapy, Ginger, Antineoplastic Agents, Vomiting, Serotonin antagonists, Antiemetics, Chemotherapy Induced Nausea and Vomiting, and Phase II Trial
Research Interests:
The 11th International Conference of the Society for Integrative Oncology (SIO) brought together more than 300 clinicians, researchers, patients, and advocates to hear and interact with world-leading experts about the latest research in... more
The 11th International Conference of the Society for Integrative Oncology (SIO) brought together more than 300 clinicians, researchers, patients, and advocates to hear and interact with world-leading experts about the latest research in the areas of nutrition, exercise, acupuncture, health services research, meditation, and other integrative disciplines. The conference theme, "Personalized Integrative Oncology: Targeted Approaches for Optimal Outcomes," highlighted innovations in personalized medicine and ways this growing field will advance the evolution of individualized integrative cancer care to the next level. This year's conference also featured a clinical track focusing on clinical information for the practicing health care professional. The conference's rigorous schedule included 3 keynotes, 4 plenary sessions, 2 interdisciplinary tumor boards, 5 workshops, 45 concurrent oral sessions, and 106 posters. In addition to the conference theme, keynote and plenar...