Mortality and morbidity of abdominal aortic aneurysm surgery have decreased significantly in time and transperitoneal approach (TPA) still preserves its popularity although retroperitoneal approach (RPA) is known to cause lower incidence... more
Mortality and morbidity of abdominal aortic aneurysm surgery have decreased significantly in time and transperitoneal approach (TPA) still preserves its popularity although retroperitoneal approach (RPA) is known to cause lower incidence and shortened duration of ileus, shorter intensive care unit (ICU) and hospital stay, earlier oral intake and less patient discomfort or pain. One hundred and fifty patients that underwent abdominal aortic aneurysm repair at our Cardiovascular Surgery Center between January, 1990 and March, 2000 were reviewed and analyzed based on the elective/emergent nature of the surgery and the type of the incision as either TPA or RPA. Significantly shorter mechanical ventilation (15.2+/-3.8 vs 10.1+/-2.3 hours) and nasogastric decompression periods (40.6+/-10.7 vs 9.1+/-2.2 hours), less need for intravenous fluid supplementation and shorter ICU stay (29.5+/-14.8 vs 18.6+/-1.9 hours) were observed with the retroperitoneal approach (P<0.001). Need for allogen...
Research Interests: Surgery, Medicine, Emergency Medical Services, Humans, Female, and 15 moreMale, Intensive Care Unit, Aged, Middle Aged, Time Factors, Mechanical Ventilation, CARDİOVASCULAR SURGERY, Aneurysm, Aortic Surgery, Aortic Aneurysm, Abdominal Aortic Aneurysm, Peritoneum, Ileus, Cardiovascular medicine and haematology, and Retroperitoneal space
Research Interests: Treatment Outcome, Medicine, Humans, Female, Male, and 15 moreAnesthesia, Two Stroke Engine, Dental Local Anesthesia, Clinical Sciences, European, Aged, Middle Aged, Occlusion, Retrospective Studies, Carotid Endarterectomy, Elsevier, Hospital Mortality, Internal Carotid Artery, High risk, and Cardiovascular medicine and haematology
Research Interests:
Research Interests:
Research Interests:
... Ascending aortic aneurysm in Behçet's disease: case report Hayati Deniz, Onur Sokullu, Soner Sanioğlu, M. Sinan Kut, Fuat Bilgen ... Altıncı ayda yapılan kontrastlı bilgisayarlı tomografide gerçek ve yalancı anevrizma gibi... more
... Ascending aortic aneurysm in Behçet's disease: case report Hayati Deniz, Onur Sokullu, Soner Sanioğlu, M. Sinan Kut, Fuat Bilgen ... Altıncı ayda yapılan kontrastlı bilgisayarlı tomografide gerçek ve yalancı anevrizma gibi herhangi bir komplikasyon görülmedi. ...
Research Interests:
Research Interests: Medicine, Animals, Male, Heart, Lung, and 15 moreExperimental Study, European, Cyanoacrylate, Myocardium, Endothelial cell, CARDİOVASCULAR SURGERY, Aorta, Control Group, Cyanoacrylates, Intimal hyperplasia, foreign body, Abdominal Aorta, Aorta Abdominal, Cardiovascular medicine and haematology, and ascending aorta
Bulgular: Açılmamış ve kullanılmış tüplerden alınan etil 2-siyanoakrilatın kültürlerinde bakteriyel ve fungal üreme saptanmadı ve kullanılmamış tüplere direkt bakteri inokülasyonu sonunda da kontaminasyon olmadı. Agar diffüzyon yöntemleri... more
Bulgular: Açılmamış ve kullanılmış tüplerden alınan etil 2-siyanoakrilatın kültürlerinde bakteriyel ve fungal üreme saptanmadı ve kullanılmamış tüplere direkt bakteri inokülasyonu sonunda da kontaminasyon olmadı. Agar diffüzyon yöntemleri ile, gram pozitif bakterilere karşı daha ...
... tarafından indekslenmektedir. "Türk Göğüs Kalp Damar Cerrahisi Dergisi Yazışma Adresi Ataşehir Mah. Ataşehir Bulvarı 48 Ada Mimoza 2-2 K:2 D:6 Ataşehir - İSTANBUL Tel: 0216 456 14 54 - e-mail: dergi@tkdcd.org www.tkdcd.org.
Research Interests:
BACKGROUND Due to the systemic and hepatic effects of cardiopulmonary bypass (CPB), open-heart surgery for patients with chronic liver disease is associated with high mortality and morbidity. In this retrospective study, we present our... more
BACKGROUND Due to the systemic and hepatic effects of cardiopulmonary bypass (CPB), open-heart surgery for patients with chronic liver disease is associated with high mortality and morbidity. In this retrospective study, we present our results of cardiac surgery on patients with non-cardiac cirrhosis. METHODS Between March 1996 and April 2000, 10 patients with chronic liver disease had open-heart surgery in our institution. Six patients were male and four were female, with a mean age of 57.1 +/- 6.85 years. Preoperative severity of liver disease was determined according to Child classification. Four cases (40%) were Child class A and six (60%) were class B. Coronary artery bypass grafting was performed in four cases, and the remaining six operations were for aortic valve replacement (AVR) and/or mitral valve replacement (MVR). Eight of the operations (80%) were performed by using cardiopulmonary bypass and two (20%) were performed as beating heart surgery. RESULTS Chest tube drainag...
Research Interests:
Research Interests:
Research Interests:
Research Interests: Humans, Female, Male, Glycoproteins, Risk factors, and 15 moreROC Curve, Length of Stay, Recurrence, Clinical Sciences, Middle Aged, Adult, Analysis of Variance, Age Factors, Biological markers, Risk Factors, Coronary Artery Disease, Area Under Curve, Predictive value of tests, Case Control Studies, and Coronary Artery Bypass
Research Interests:
Atheromatous plaques in the ascending aorta are major risk factors for strokes caused by macroembolization after coronary artery surgery. Detection of plaque formations and changes in the surgical strategy are very important. This study... more
Atheromatous plaques in the ascending aorta are major risk factors for strokes caused by macroembolization after coronary artery surgery. Detection of plaque formations and changes in the surgical strategy are very important. This study was planned to compare value direct palpation and multislice computerized tomography to establish aortic plaques and to establish clinical predictors of aortic calcification. Fifty-four patients who underwent coronary bypass surgery were included in this prospective and diagnostic study. Proximal portion of each patient's aorta was evaluated with multislice computerized tomography and was compared with direct palpation. The efficacy of intraoperative palpation to predict calcifications was studied with ROC analysis and the predictors of aortic plaque formation were analyzed using logistic regression analysis. Atheromatous plaques were detected with palpation in four patients (7.4%), and with multislice tomography in six patients (11.1%). The aort...
Research Interests: Stroke, Prospective studies, Humans, Female, Male, and 15 morePalpation, Differential Diagnosis, Risk factors, ROC Curve, Middle Aged, Calcinosis, Risk Factors, Coronary Artery Disease, Sensitivity and Specificity, X ray Computed Tomography, Aorta, Logistic Models, Carotid Stenosis, Postoperative Complications, and Coronary Artery Bypass
We analyzed the postoperative short- and mid-term outcomes of a series of patients with annuloaortic ectasia who underwent a modified Bentall operation in our clinic from September 2000 through March 2006. The study included 44 patients.... more
We analyzed the postoperative short- and mid-term outcomes of a series of patients with annuloaortic ectasia who underwent a modified Bentall operation in our clinic from September 2000 through March 2006. The study included 44 patients. Their average age was 53.4 +/- 14.1 years. The underlying disease was degenerative aortic aneurysm in 42 patients (95.5%) and acute aortic dissection in 2 patients (4.5%). Six patients (13.6%) had Marfan phenotype. Aortic insufficiency was moderate in 30 patients (68.2%) and severe in 14 patients (31.8%). In our modification of the Bentall technique, we completed the resection of the aortic root while leaving 5 to 10 mm of native aortic wall tissue to support the anastomosis. A long piece of Teflon felt (width, 0.5-1 cm) was laid on the annulus, and nonpledgeted 2-0 polyester sutures were passed in turn through the Teflon felt, the preserved aortic tissue, and the aortic annulus. A thin piece of Teflon felt was also used in the coronary artery reimp...
Research Interests:
Research Interests:
The accelerated-recovery approach, involving early extubation, early mobility, decreased duration of intensive care unit stay, and decreased duration of hospitalization has recently become a controversial issue in cardiac surgery. We... more
The accelerated-recovery approach, involving early extubation, early mobility, decreased duration of intensive care unit stay, and decreased duration of hospitalization has recently become a controversial issue in cardiac surgery. We investigated timing of extubation, length of intensive care unit stay, and duration of hospitalization in 225 consecutive cardiac surgery patients. Of the 225 patients, 139 were male and 86 were female; average age was 49.73 +/- 16.95 years. Coronary artery bypass grafting was performed in 127 patients; 65 patients underwent aortic and/or mitral or pulmonary valvular operations; 5 patients underwent valvular plus coronary artery operations; and in 28 patients surgical interventions for congenital anomalies were carried out. The accelerated-recovery approach could be applied in 169 of the 225 cases (75.11%). Accelerated-recovery patients were extubated after an average of 3.97 +/- 1.59 hours, and the average duration of stay in the intensive care unit wa...
Research Interests:
Due to the systemic and hepatic effects of cardiopulmonary bypass (CPB), open-heart surgery for patients with chronic liver disease is associated with high mortality and morbidity. In this retrospective study, we present our results of... more
Due to the systemic and hepatic effects of cardiopulmonary bypass (CPB), open-heart surgery for patients with chronic liver disease is associated with high mortality and morbidity. In this retrospective study, we present our results of cardiac surgery on patients with non-cardiac cirrhosis. Between March 1996 and April 2000, 10 patients with chronic liver disease had open-heart surgery in our institution. Six patients were male and four were female, with a mean age of 57.1 +/- 6.85 years. Preoperative severity of liver disease was determined according to Child classification. Four cases (40%) were Child class A and six (60%) were class B. Coronary artery bypass grafting was performed in four cases, and the remaining six operations were for aortic valve replacement (AVR) and/or mitral valve replacement (MVR). Eight of the operations (80%) were performed by using cardiopulmonary bypass and two (20%) were performed as beating heart surgery. Chest tube drainage and transfusion needs of ...
Research Interests:
Research Interests: Survival Analysis, Stroke, Prospective studies, Humans, Follow-up studies, and 10 moreDental Local Anesthesia, General Anesthesia, Aged, Middle Aged, Carotid Endarterectomy, Coronary Artery Disease, Coronary artery bypass surgery, Intraoperative Period, Cardiovascular medicine and haematology, and Coronary Artery Bypass
The aims of this study were to elucidate the incidence of mitral regurgitation during off-pump coronary artery bypass (OPCAB) surgery to evaluate the relationship of the changes with ventricular function and possible mitral valve... more
The aims of this study were to elucidate the incidence of mitral regurgitation during off-pump coronary artery bypass (OPCAB) surgery to evaluate the relationship of the changes with ventricular function and possible mitral valve regurgitation caused by positioning. Included in the study were 60 consecutive patients who underwent CAB grafting on the beating heart. We monitored several hemodynamic variables (systolic arterial pressure, mean arterial pressure, right atrial pressure, pulmonary capillary wedge pressure, and heart rate) at baseline and after each anastomosis and used transesophageal echocardiography (TEE) routinely after sternotomy, during each anastomosis, and after completion of the operation. Valvular functions, ejection fraction, and wall motion systolic index were recorded during each TEE evaluation. All of the patients underwent complete revascularization. We performed 132 consecutive OPCAB anastomoses in 60 patients (60 left anterior descending artery [LAD], 20 right coronary artery [RCA], 45 left circumflex coronary artery [LCX], and 7 diagonal artery grafts). During LCX anastomosis, 38 (84.4%) of 45 patients developed moderate mitral regurgitation. The wall motion score index (WMSI) significantly increased during CX grafting, as was demonstrated by higher WMSI values than for the RCA, diagonal, and LAD grafts. The ejection fraction was decreased significantly during CX and RCA anastomoses compared with baseline levels. The hemodynamic changes were in accord with these findings. The greatest hemodynamic compromise was seen during CX anastomosis. Positional mitral regurgitation occurs frequently and is a major contributor to hemodynamic instability during posterior- and lateral-wall revascularization during the OPCAB procedure.
Research Interests:
Atrial fibrillation is a rhythm disorder commonly seen early after coronary artery bypass grafting, and it increases morbidity. To investigate the effectiveness of magnesium sulfate in the prophylaxis of atrial fibrillation, we conducted... more
Atrial fibrillation is a rhythm disorder commonly seen early after coronary artery bypass grafting, and it increases morbidity. To investigate the effectiveness of magnesium sulfate in the prophylaxis of atrial fibrillation, we conducted a prospective, randomized, placebo-controlled clinical study on 200 consecutive patients in whom we performed elective and initial coronary artery bypass grafting operations. In each group 50% of patients underwent beating-heart operations. In the treatment group 100 patients (76 men and 24 women; mean age, 57.63 +/- 9.68 years) received 24.34 mEq (3 g) of magnesium sulfate in 100 mL of saline solution that was administered over 2 hours (50 mL/h) preoperatively, perioperatively, and at postoperative days 0, 1, 2, and 3. In the control group 100 patients (74 men and 26 women; mean age, 59.96 +/- 9.29 years) received only 100 mL of saline solution according to the same administration schedule as the treatment group. Atrial fibrillation developed in 15 patients from the treatment group and in 16 patients from the control group. The arrhythmia developed after 37.87 +/- 12.76 and 45.26 +/- 15.27 hours in the treatment and control groups, respectively. Although a significant relationship was found between low magnesium sulfate levels and increased incidence of atrial fibrillation (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.05), when the incidence of postoperative atrial fibrillation is concerned, no significant difference was found between the 2 groups (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;.05). Also, no significant difference was found between operations with cardiopulmonary bypass and beating-heart operations in terms of atrial fibrillation incidence (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;.05). However, atrial fibrillation extended the duration of hospital stay in both groups (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.05). Our findings indicate that magnesium sulfate infusion alone is not sufficient for the prophylaxis of atrial fibrillation.
Research Interests: Humans, Magnesium, Female, Male, Atrial Fibrillation, and 15 moreHeart rate, Incidence, Length of Stay, Clinical Sciences, Aged, Adult, Clinical Study, Arrhythmia, Coronary artery bypass surgery, Magnesium Sulfate, Control Group, Cardiopulmonary bypass, Coronary artery bypass graft, Cardiovascular medicine and haematology, and Coronary Artery Bypass
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Cyanidase is a new enzyme preparation capable of degrading cyanide in industrial wastewaters to ammonia and formate in an apparently one-step reaction, down to very low concentrations. This enzyme has both a high selectivity and affinity... more
Cyanidase is a new enzyme preparation capable of degrading cyanide in industrial wastewaters to ammonia and formate in an apparently one-step reaction, down to very low concentrations. This enzyme has both a high selectivity and affinity toward cyanide. A granular form of the biocatalyst was used in a recirculation fixed bed reactor in order to characterize the new biocatalyst with respect to pH, ionic strength, common ions normally present in wastewaters, mass transfer effects, and temperature. Long term stability was investigated. The kinetics of the enzymatic degradation of cyanide were studied in a batch reactor using the powdered immobilized enzyme preparation and modeled using a simple Michaelis-Menten equation.
Research Interests:
Research Interests: Adolescent, Catheterization, Humans, Child, Blood Pressure, and 15 moreFemale, Male, Incidence, Clinical Sciences, Aged, Middle Aged, Adult, Degeneration, Age Factors, Proportional Hazards Models, Cardiopulmonary bypass, Postoperative Complications, Child preschool, Heart Valve Prosthesis Implantation, and Cardiovascular medicine and haematology
To investigate experimentally the possible histopathological effects of ethyl 2-cyanoacrylate glue when used as a tissue adhesive in cardiovascular and thoracic surgery. Sprague-Dawley rats were used for this study. For histopathological... more
To investigate experimentally the possible histopathological effects of ethyl 2-cyanoacrylate glue when used as a tissue adhesive in cardiovascular and thoracic surgery. Sprague-Dawley rats were used for this study. For histopathological investigation, a study group of 144 rats in which intentionally produced lesions in myocardium (n=36), ascending aorta (n=36), lung (n=36) and abdominal aorta (n=36) were closed by using ethyl 2-cyanoacrylate was compared with the control group (n=144) in which the same lesions were closed by using sutures. On each of days 1, 7, 15, 30, 45 and 60, six rats from the study group and six rats from the control group were sacrificed and analyzed for each relevant organ in terms of bonding of ethyl 2-cyanoacrylate polymers to tissue, foreign body reaction, inflammatory reactions, and necrosis. Endothelial cell damage, intimal hyperplasia, and thrombus formation were also evaluated in arteriotomy sections. In histopathological analysis of vascular, myocardial and pulmonary tissue sections, there was no significant histopathological difference between conventionally sutured tissues and ethyl 2-cyanoacrylate-applied tissues. As no significant difference between conventional suture and ethyl 2-cyanoacrylate application was detected in terms of histopathological reactions, ethyl 2-cyanoacrylate may be considered as an alternative or adjunct to conventional techniques in controlling hemorrhage that cannot be controlled by conventional methods, in tissue repair and in the control of pulmonary air leakage, and may be used in vascular, myocardial and pulmonary surgery.