Papers by Stephen Rogerson
American Journal of Reproductive Immunology, 2004
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PLoS ONE, 2007
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Journal of immunology (Baltimore, Md. : 1950), Jan 15, 2014
Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphoc... more Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphocytes is poorly understood. In addition, exposure to the Plasmodium parasite is associated with altered distribution of peripheral memory B cell (MBC) subsets. To study the combined impact of high malaria exposure and pregnancy in B cell subpopulations, we analyzed PBMCs from pregnant and nonpregnant individuals from a malaria-nonendemic country (Spain) and from a high malaria-endemic country (Papua New Guinea). In the malaria-naive cohorts, pregnancy was associated with a significant expansion of all switched (IgD(-)) MBC and a decrease of naive B cells. Malaria-exposed women had more atypical MBC and fewer marginal zone-like MBC, and their levels correlated with both Plasmodium vivax- and Plasmodium falciparum-specific plasma IgG levels. Classical but not atypical MBC were increased in P. falciparum infections. Moreover, active atypical MBC positively correlated with proinflammatory cyt...
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Journal of Infectious Diseases, 2015
Passively acquired respiratory syncytial virus (RSV)-neutralizing antibody protects against RSV-... more Passively acquired respiratory syncytial virus (RSV)-neutralizing antibody protects against RSV-associated lower respiratory infections but placental malaria (PM) and maternal hypergammaglobulinemia might interfere with transplacental immunoglobulin transport. We measured RSV plaque reduction neutralization (PRN) antibody titers in 300 full-term maternal/cord serum pairs in two cohorts in malaria-endemic Papua New Guinea: Alexishafen (2005-08) and FIS (2011-13). We defined impaired transport as a cord to maternal titer ratio (CMTR) <1.0 and a protective RSV PRN titer (PRNT) as ≥1:200. PM and hypergammaglobulinemia occurred in 60% and 54% of Alexishafen mothers versus 8% and 9% of FIS mothers, respectively. 34% of Alexishafen and 32% of FIS pairs demonstrated impaired transport. Multivariate modeling revealed significant associations between increasing maternal IgG (log2) and impaired transport (adjusted OR, Alexishafen: 2.68 [1.17-6.14], FIS: 6.94; [1.94-24.8]) but no association with PM. 34% of Alexishafen and 31% of FIS cord PRNTs were <1:200. Impaired RSV Ab transport was observed in ∼one-third of maternal/cord pairs. Hypergammaglobulinemia, but not PM, was associated with impaired transport, particularly among women with low RSV PRNT. Detection of RSV PRNT <1:200 in one-third of cord sera supports efforts to increase levels of RSV neutralizing antibody in pregnant women through maternal immunization.
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Malaria Journal, 2014
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Deadly Parasite, Susceptible Host, 2001
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PLoS Medicine, 2006
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Microbiology Australia, 2016
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The Journal of Infectious Diseases, Aug 1, 2006
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Experimental Parasitology, May 31, 1997
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The Journal of Infectious Diseases, Nov 1, 1999
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The American Journal of Tropical Medicine and Hygiene, May 1, 2007
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British journal of clinical pharmacology, Jan 17, 2016
To investigate the safety, tolerability and pharmacokinetics of co-administered azithromycin (AZI... more To investigate the safety, tolerability and pharmacokinetics of co-administered azithromycin (AZI) and piperaquine (PQ) in pregnant Papua New Guinean women. Thirty women (median age 22 years; 16-32 weeks gestation) were given three daily doses of 1 g AZI plus 960 mg PQ tetraphosphate with detailed monitoring/blood sampling over 42 days. Plasma AZI and PQ were assayed using liquid chromatography-mass spectrometry and high performance liquid chromatography, respectively. Pharmacokinetic analysis was by population-based compartmental models. The treatment was well tolerated. The median [inter-quartile range] increase in rate-corrected QT interval 4 h post-dose (12 [6-26] msec(0.5) ) was similar to that in previous studies of AZI given in pregnancy with other partner drugs. Six women with asymptomatic malaria cleared their parasitaemias within 72 h. Two apararasitaemic women developed late uncomplicated P. falciparum infections on Days 42 and 83. Compared with previous pregnancy studies...
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Journal of Clinical Microbiology, Apr 1, 2003
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The American Journal of Tropical Medicine and Hygiene, Oct 1, 2006
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The American Journal of Tropical Medicine and Hygiene, 1994
The relationship between antigenic variation, cytoadherence, rosette formation, and the pathogene... more The relationship between antigenic variation, cytoadherence, rosette formation, and the pathogenesis of malaria has led to great interest in the diversity of these properties in Plasmodium falciparum isolates from different communities. In this study, we extend previous investigations by delineating the spectrum of agglutinating phenotypes, adherence to C32 melanoma cells, human umbilical vein endothelial cells (HUVEC), CD36, and intracellular adhesion molecule-1 (ICAM-1), and rosette-forming ability of a group of 20 P. falciparum isolates from Papua New Guinean children. Agglutination phenotypes were determined by using both the children's convalescent serum and a panel of adult immune sera. The wide range of variant antigenic types in the community was demonstrated by the failure of the agglutination assays to identify any two isolates with the same agglutinating phenotype in this, the largest study of its kind. Comparison of agglutination profiles from fresh and cryopreserved isolates demonstrated the general acceptability of cryopreservation before testing, but cautioned that some isolates may undergo selection and phenotypic change during the process. Nineteen isolates were able to bind to at least one of the four ligands studied and showed marked variation in both avidity and specificity of binding. The purified proteins ICAM-1 and CD36 proved to be the most useful assay ligands for investigating field isolates, with 18 isolates binding to at least one protein and 14 to both. No correlation was found between the binding of isolates to any two ligands nor between the binding of a standardized inoculum and the level of the patient's presenting parasitemia. All isolates from the study group were found to form rosettes (at a mean rate of 14.6% of cultured trophozoites involved in rosettes). A lack of correlation between rosette formation and CD36 binding suggests that the previously reported role of CD36 as a rosette formation receptor may not be important for isolates from Papua New Guinea.
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Pathogens and Global Health, Mar 1, 2013
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Biorheology, 1995
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Advances in Experimental Medicine and Biology, 2009
... Acknowledgments Stephen Rogerson is supported by the National Health and Medical Research Cou... more ... Acknowledgments Stephen Rogerson is supported by the National Health and Medical Research Council of Australia and the Malaria in Pregnancy ... Poespoprodjo, JR, Fobia, W., Kenangalem, E., Lampah, DA, Warikar, N., Seal, A., McGready, R., Sugiarto, P., Tjitra, E., Anstey ...
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Papers by Stephen Rogerson