The worldwide prevalence and risk factors for kidney stones in patients with fibrodysplasia ossificans progressiva (FOP) are unknown. We conducted a survey of 383 patient-members of the International Fibrodysplasia Ossificans Progressiva... more
The worldwide prevalence and risk factors for kidney stones in patients with fibrodysplasia ossificans progressiva (FOP) are unknown. We conducted a survey of 383 patient-members of the International Fibrodysplasia Ossificans Progressiva Association, comprising the entire global membership of the international FOP community. Two hundred seven patients from 31 nations and 6 continents (54%) responded. Nineteen of 207 respondents had kidney stones, revealing a worldwide prevalence of 9.2%. In a confirmatory follow-up study of subjects participating in a longitudinal FOP natural history study, 9 of 114 individuals reported a history of kidney stones (7.9%). In both study populations patients with kidney stones were found to be more functionally impaired compared to those without nephrolithiasis. The prevalence of kidney stones in the adult FOP population of the Unites States was 15.8% (9/57 individuals) compared to a sex- and age-weighted prevalence of 4.5% (p=4×10-5) in the general po...
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Abstract Dysregulation of the bone morphogenic protein (BMP) 4-signaling pathway can explain many developmental and postnatal features of fibrodysplasia ossificans progressive (FOP). However, many puzzling clinical features of the disease... more
Abstract Dysregulation of the bone morphogenic protein (BMP) 4-signaling pathway can explain many developmental and postnatal features of fibrodysplasia ossificans progressive (FOP). However, many puzzling clinical features of the disease strongly implicate an ...
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... Frederick S. Kaplan, MD,1,2,4 David L. Glaser, MD,1,4 Eileen M. Shore, PhD,1,3,4 Gregory K. Deirmengian, MD,1,4 Rishi Gupta, MD,1,4 Patricia Delai, MD,5 Rolf Morhart, MD,6 Roger Smith, MD,7 ... 10. Luchetti W, Cohen RB, Hahn GV, Rocke... more
... Frederick S. Kaplan, MD,1,2,4 David L. Glaser, MD,1,4 Eileen M. Shore, PhD,1,3,4 Gregory K. Deirmengian, MD,1,4 Rishi Gupta, MD,1,4 Patricia Delai, MD,5 Rolf Morhart, MD,6 Roger Smith, MD,7 ... 10. Luchetti W, Cohen RB, Hahn GV, Rocke DM, Helpin M, Zasloff M, Kaplan FS. ...
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Acute stroke therapy is evolving rapidly as research moves toward extending the time window for treatment so that more patients can benefit. As physiology-based imaging increasingly is used in patient selection, it is becoming evident... more
Acute stroke therapy is evolving rapidly as research moves toward extending the time window for treatment so that more patients can benefit. As physiology-based imaging increasingly is used in patient selection, it is becoming evident that rigid time windows are not applicable to individual patients. Xenon CT has an important role in acute stroke therapeutic intervention as a quantitative, reproducible, rapid, and safe modality, which can provide valuable physiologic data that can optimize patient triage and aid in management.
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Research Interests:
Technological advances have helped to improve the efficiency of treating patients with large vessel occlusion in acute ischemic stroke. Unfortunately, the sequence of events prior to reperfusion may lead to significant treatment delays.... more
Technological advances have helped to improve the efficiency of treating patients with large vessel occlusion in acute ischemic stroke. Unfortunately, the sequence of events prior to reperfusion may lead to significant treatment delays. This study sought to determine if high-volume (HV) centers were efficient at delivery of endovascular treatment approaches. A retrospective review was performed of nine centers to assess a series of time points from obtaining a CT scan to the end of the endovascular procedure. Demographic, radiographic and angiographic variables were assessed by multivariate analysis to determine if HV centers were more efficient at delivery of care. A total of 442 consecutive patients of mean age 66 ± 14 years and median NIH Stroke Scale score of 18 were studied. HV centers were more likely to treat patients after intravenous administration of tissue plasminogen activator and those transferred from outside hospitals. After adjusting for appropriate variables, HV cen...
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Background and Purpose— Previous work that predated the availability of the safer stent-retriever devices has suggested that general anesthesia (GA) may have a negative impact on outcomes in patients with acute ischemic stroke undergoing... more
Background and Purpose— Previous work that predated the availability of the safer stent-retriever devices has suggested that general anesthesia (GA) may have a negative impact on outcomes in patients with acute ischemic stroke undergoing endovascular therapy. Methods— We reviewed demographic, clinical, procedural (GA versus local anesthesia [LA], etc), and site-adjudicated angiographic and clinical outcomes data from consecutive patients treated with the Solitaire FR device in the investigator-initiated North American SOLITAIRE Stent-Retriever Acute Stroke (NASA) Registry. The primary outcomes were 90-day modified Rankin Scale, mortality, and symptomatic intracranial hemorrhage. Results— A total of 281 patients from 18 centers were enrolled. GA was used in 69.8% (196/281) of patients. Baseline demographic and procedural factors were comparable between the LA and GA groups, except the former demonstrated longer time-to-groin puncture (395.4±254 versus 337.4±208 min; P =0.04), lower N...
Research Interests: Neurology, Medicine, Humans, Female, Male, and 15 moreBrain Ischemia, Registries, Dental Local Anesthesia, Clinical Sciences, North America, General Anesthesia, Aged, Middle Aged, Odds ratio, Cardiovascular Diseases, Neurosciences, Nervous System Diseases, Endovascular Procedures, modified Rankin Scale, and Cardiovascular medicine and haematology
Background and Purpose— Few data on xenon computed tomography-based quantitative cerebral blood flow (CBF) in spontaneous intracerebral hemorrhage have been reported. We correlated perihematomal CBF in a retrospective series of 42... more
Background and Purpose— Few data on xenon computed tomography-based quantitative cerebral blood flow (CBF) in spontaneous intracerebral hemorrhage have been reported. We correlated perihematomal CBF in a retrospective series of 42 subacute spontaneous intracerebral hemorrhage patients undergoing xenon computed tomography with in-hospital discharge status and mortality. Methods— We calculated 3 area-weighted mean CBF values: (1) within the computed tomography-visible rim of perihematomal edema, (2) within a 1-cm marginal radius around the hematoma, and (3) all cortical regions of interest immediately adjacent to the hematoma. Primary outcomes were in-hospital mortality and discharge status (ordinally as 0=home, 1=acute rehabilitation, 2=nursing home, 3=death). Discharge status was used as a surrogate for in-hospital functional outcome. Results— Median hematoma volume was 14.4 cm 3 (range, 2 to 70). Median perihematomal (low-attenuation rim) CBF was 21.9 cm 3 ·100 g −1 ·min −1 (range,...
Research Interests: Medicine, Stroke, Brain, Humans, Hospitalization, and 15 moreClinical Sciences, Aged, Middle Aged, Blood Flow, Retrospective Studies, Intracerebral Hemorrhage, Hematoma, Cerebral Blood Flow, Blood Flow Velocity, Cerebral Hemorrhage, Intraventricular Hemorrhage, Neurosciences, Predictive value of tests, Cardiovascular medicine and haematology, and functional outcome
Research Interests: Neurology, Medicine, Catheterization, Humans, Female, and 14 moreClinical Sciences, Girl, Occlusion, Thrombosis, Young Children, Tissue Plasminogen Activator, Basilar Artery, Neurosciences, Neurocritical Care, Thrombolytic Therapy, Revascularization, Child preschool, Thrombolysis, and Vertebrobasilar insufficiency
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Abstract Growth of large grain form of CuInSe 2 has been described and discussed. It has been shown that specific treatments such as Cd/Bi doping of the as-synthesized polycrystalline CuInSe 2 bulk flux and localized annealing (∼600°C) of... more
Abstract Growth of large grain form of CuInSe 2 has been described and discussed. It has been shown that specific treatments such as Cd/Bi doping of the as-synthesized polycrystalline CuInSe 2 bulk flux and localized annealing (∼600°C) of the as-deposited polycrystalline CuInSe 2 thin films lead to large grain (bulk: 1000 μm, thin film: 10 μm) CuInSe 2 .
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Background and Purpose: Several anticonvulsant drugs have been found to be neuroprotective in preclinical models of stroke, and such drugs may possibly be given in combination with other stroke treatments such as recombinant tissue... more
Background and Purpose: Several anticonvulsant drugs have been found to be neuroprotective in preclinical models of stroke, and such drugs may possibly be given in combination with other stroke treatments such as recombinant tissue plasminogen activator (rt-PA). The goal of this study was to test for potential interactions between rt-PA and selected anticonvulsants. Methods: A spectrophotomeric assay was used to monitor the lysis of fibrin clots in the presence of rt-PA and the drugs levetiracetam, valproic acid, phenytoin and phenobarbital. Results: The drugs tested were found to have no effect on either the rate or total amount of lysis induced by rt-PA. Conclusions: Although further studies are required in order to explore the effects of these drugs in stroke patients, the results suggest that co-administration of rt-PA and anticonvulsant drugs may be safe and viable.