Papers by Ravibabu kalahasthi
Journal of Krishna Institute of Medical Sciences University, 2020
Background: The association of risk factors with the insulin resistance/sensitivity biomarkers we... more Background: The association of risk factors with the insulin resistance/sensitivity biomarkers were assessed in population based studies but not in industrial settings. Aim and Objectives: This study assessed the association of risk factors with the Insulin Resistance (IR) and Insulin Sensitivity (IS) biomarkers among industrial workers. Material and Methods: A cross-sectional study. IR and IS biomarkers were assessed in 137 (94 male and 43 female) industrial workers. Serum levels of glucose, Triglyceride (TG) and High Density Lipoprotein–Cholesterol (HDL-C) were measured using diagnostic kit. Serum level of insulin was quantified using ELISA method. IR and IS biomarkers were compared with gender, age, and occurrence of smoking, alcohol consumption, waist circumference, body mass index, hypertension, diabetes, elevated triglyceride, low HDL-C and metabolic syndrome among industrial workers. Results: The levels of IR biomarkers: Homeostatic Model Assessment of Insulin Resistance (HOM...
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Indian Journal of Occupational and Environmental Medicine, 2019
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Asian Biomedicine, 2021
Background Association of work schedule in industrial workers with the progression of metabolic s... more Background Association of work schedule in industrial workers with the progression of metabolic syndrome, insulin resistance, and serum adipokine concentrations is incompletely explored. Objective To determine the association of work schedule with the progression of metabolic syndrome, insulin resistance, and adipokine concentrations in industrial workers. Methods In a cross-sectional study design of industrial workers we compared metabolic syndrome, insulin resistance, and adipokines concentration between workers in the day shift (n = 52), rotational shift (n = 21), and night shift (n = 15). The international Diabetes Federation criteria were used to diagnose metabolic syndrome. We used a homeostatic model assessment of insulin resistance (HOMA-IR). Serum insulin, leptin, and adiponectin concentrations were measured using enzyme-linked immunosorbent assays. Serum glucose, triglyceride, and high-density lipoprotein cholesterol (HDL-C) concentrations were monitored using Prietest cli...
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Angiology, 2010
Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitiv... more Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitivity C-reactive protein (hsCRP) concentrations were measured in samples from 168 patients in the first 24 hours after the onset of stroke and 80 age-and sex-matched control participants. In patients with stroke, median serum anti-HSP27 titer was significantly higher than that of the control group (0.18 [0.14-0.28] vs 0.08 [0.04-0.12], P < .001). Median serum hsCRP concentration was also significantly higher in patients compared with the control group (11.43 [8.07-13.53] vs 3.23 [1.66-6.24], P < .001). Serum anti-HSP27 and hsCRP concentrations did not differ significantly among patients with different stroke types. Neither serum anti-HSP27 nor hsCRP levels predicted 6-month prognosis in the patients with stroke. We conclude that serum anti-HSP27 titers and hsCRP concentrations are elevated in patients with stroke but do not distinguish between stroke types or predict 6-month prognosis.
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Introduction: Studies suggest that chronic lead (Pb) exposure may induce Deoxyribonucleic acid (D... more Introduction: Studies suggest that chronic lead (Pb) exposure may induce Deoxyribonucleic acid (DNA) damage. However, there is no synthesised evidence in this regard. We systematically reviewed existing literature and synthesised evidence on the association between chronic Pb exposure and markers of genotoxicity. Methods: Observational studies reporting biomarkers of DNA damage among occupationally Pb-exposed and unexposed controls were systematically searched from PubMed, Scopus and Embase databases from inception to January 2022. The markers included were micronucleus frequency (MN), chromosomal aberrations, comet assay, and 8-hydroxy-deoxyguanosine. During the execution review, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Mean differences in the biological markers of DNA damage between Pb-exposed and control groups were pooled using the random-effects model. The heterogeneity was assessed using the Cochran- Q test and I s...
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Toxicology, 2022
Recent evidences suggest the role of chronic lead (Pb) exposure in altering immunological paramet... more Recent evidences suggest the role of chronic lead (Pb) exposure in altering immunological parameters. Present study aimed to systematically review existing literature and synthesize quantitative evidence on the association between chronic Pb exposure and changes in immunological markers. Observational studies reporting immunological markers such as leukocyte derivative counts (CD3+, CD4+, CD8+, CD45+, CD56+, lymphocyte, and total leukocyte), cytokine, Immunoglobulin (Igs), C-reactive protein (CRP) among Pb-exposed and unexposed controls were systematically searched from PubMed, Scopus and Embase digital databases from inception to January 2021. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adhered during systematic review. Mean differences in the immunological markers between Pb-exposed and control groups were pooled using random-effects model. The heterogeneity was assessed using Cochran-Q test and I2 statistic. The review included forty studies reporting immunological markers in Pb-exposed and unexposed control groups. The occupational Pb-exposed group exhibited significantly higher BLL, impaired immunological markers, characterized by a marginal lowering in lymphocyte count, lymphocyte subsets (CD3+, CD4+, CD4+/CD8+ ratio), INF-γ and IgG levels, while CD8+, IgM, IgA, IgE, and cytokines (IL-4, IL-6, IL-10, and TNF-α) exhibited a trend of higher values in comparison to the control group. Further, inflammatory marker viz., total leukocyte count was significantly higher among Pb-exposed. The included studies exhibited high levels of heterogeneity. In conclusion, Occupational Pb exposure alters the immunological markers such as the circulating cytokines and leukocyte counts. However, high-quality, multicentered studies are required to strengthen present observations and further understand the Pb's role on the immune system. Prospero Registration ID: CRD42021228252.
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Received: September 2012, Accepted: December 2013 Background: There are many controversies report... more Received: September 2012, Accepted: December 2013 Background: There are many controversies reported about the association between blood lead levels and blood pressure among lead exposed workers. Studies have suggested incorporating lifestyle factors along with blood lead levels. The present study aimed to evaluate the effect of lead exposure on blood pressure changes among lead exposed workers in contemplation of lifestyle factors. Materials and methods: Study design is descriptive. Three hundred ninety one male lead exposed workers were enrolled. The subjects were categorized into four groups according to their blood lead levels by using quartile distribution. Blood lead levels were measured by using an atomic absorption spectrophotometer. Blood pressure was measured by using a standard mercury sphygmomanometer. Data were analyzed by using SPSS (Version 7.5). Results: The mean systolic blood pressure in quartile-2 blood lead levels and the prevalence of hypertensive in quartile-4 b...
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International Journal of Medical Science and Public Health, 2016
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Indian Journal of Occupational and Environmental Medicine, 2006
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Toxicological & Environmental Chemistry, 2008
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International Journal of Environmental Health Research, 2013
The present study was carried out to find the relationship between blood lead levels (BLLs) and m... more The present study was carried out to find the relationship between blood lead levels (BLLs) and morbidities among 391 male workers employed in a factory manufacturing lead-acid storage batteries. A predesigned questionnaire was used to collect information on subjective health complaints and clinical observation made during a clinical examination. In addition to monitoring of BLL, other laboratory parameters investigated included hematological and urine-δ-aminolevulinic acid levels. Logistic regression method was used to evaluate the relationship between BLL and morbidities. The BLL among workers was associated with an odd ratio of respiratory, gastrointestinal (GI), and musculoskeletal (MSD) morbidities. Mean corpuscular hemoglobin and packed cell volume variables were associated with respiratory problems. The variables of alcohol consumption and hematological parameters were associated with GI complaints. Systolic blood pressure was related to MSD in workers exposed to Pb during the manufacturing process.
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Environmental Bioindicators, 2006
Objective. The effect of cadmium exposure on serum amylase activity has been monitored in cadmium... more Objective. The effect of cadmium exposure on serum amylase activity has been monitored in cadmium plating workers of Bangalore City (India).Methods. Fifty subjects using cadmium during electroplating formed the study group. An equal number of age–sex matched subjects working in administrative sections formed the control group. Urinary cadmium levels were determined by using a flameless atomic absorption spectrophotometer. Serum amylase
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Chemico-Biological Interactions, 2006
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… Science: An Indian …, 2007
Objective The effect of chromium (VI) exposure on serum amylase activity has been monitored in ch... more Objective The effect of chromium (VI) exposure on serum amylase activity has been monitored in chromium plating workers of Bangalore City (India). Methods: 50 subjects using chromium (VI) during electroplating formed the study group. An equal number of agesex matched ...
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The International Journal of Occupational and Environmental Medicine, 2020
Background: The major portion of lead in the body resides in skeletal system. The bone turnover a... more Background: The major portion of lead in the body resides in skeletal system. The bone turnover affects the release of lead into the circulation from bones. The bone turnover biomarkers (BTM) in lead-battery workers with long-term exposure to lead have not been explored yet. Objective: To evaluate the BTM (formation and resorption) in lead-battery workers with long-term exposure to lead in lead-battery manufacturing plant. Methods: 176 male lead-exposed workers and 80 matched comparison group were studied. All participants were examined for blood lead levels (BLLs), bone formation biomarkers—serum osteocalcin (OC), alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP)—and bone resorption biomarkers—serum pyridinoline (PYD), deoxypyridinoline (DPYD), tartarate-resistant acid phosphatase-5b (TRACP-5b), and urinary hydroxyproline (UHYP). Results: We found a significantly higher bone formation biomarkers such as BALP (p=0.007) and bone resorption biomarkers, eg, PYD (p=0...
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Journal of Chemical Health Risks, 2018
Most of the studies assessed the effect of Pb-exposure on serum total calcium and phosphorus. Thi... more Most of the studies assessed the effect of Pb-exposure on serum total calcium and phosphorus. This study assessed the effect of Pb- exposure on serum total calcium (TCa 2+ ) and phosphorus (P) components such as corrected calcium (CCa 2+ ), ionized calcium (ICa 2+ ), percentage of ICa 2+ from TCa 2+, percentage of ICa 2+ from CCa 2+, ratios of TCa 2+ : P, CCa 2+ : P, ICa 2+ : P and product of Ca 2+ and P in workers of different category of Pb-exposure. This study enrolled 176 male Pb-exposed workers and categorized into two groups based on blood lead levels (BLLs) recommended by BEI-ACGIH. The low Pb-exposure group is 86 workers with their BLLs is ≤ 30 µg/dL and high Pb-exposure is 90 workers with their BLLs is > 30 µg/dL). 80 healthy workers with no occupational exposure to Pb were included them as control for the comparison. The serum calcium, phosphorus and albumin concentrations were done by using diagnostic kit methods. BLLs were estimated by using the flame atomic absorptio...
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Journal of Research in Health Sciences, 2018
Background: Most of studies assessed the effect of Pb-exposure on serum total magnesium (tMg). Th... more Background: Most of studies assessed the effect of Pb-exposure on serum total magnesium (tMg). The hypomagnesium condition depended on protein concentration in the sample and influence of lifestyle factors. This study assessed the effect of Pb- exposure on serum tMg, corrected Mg (cMg), ionized Mg (iMg), percentage of iMg from tMg, and percentage of iMg from cMg with contemplation of lifestyle factors. Study design: Case control study. Methods: The serum magnesium fractions were assessed in 176 male Pb-exposed workers in the year 2015 at Tamil nadu in India and 80 control subjects with no occupational exposure of Pb. The serum tMg and albumin concentrations were estimated using diagnostic kit methods. Blood lead levels (BLLs) were estimated using atomic absorbtion spectrophotometer method. The fraction of cMg and iMg were calculated from serum tMg and albumin concentration among individual subjects. Results: The BLLs was significantly (P<0.001) increased in the study group as com...
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Chemosphere
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International Journal of Medical Science and Public Health, 2016
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Toxicology
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Papers by Ravibabu kalahasthi