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Beta-alanine is a non-essential amino acid that is naturally produced by the human body and used by many athletes and practitioners of physical activity to reduce muscle fatigue and to increase performance in high performance exercises.... more
Beta-alanine is a non-essential amino acid that is naturally produced by the human body and used by many athletes and practitioners of physical activity to reduce muscle fatigue and to increase performance in high performance exercises. As a precursor of intramuscular carnosine, it has been shown to reduce the hydrogen ions that cause muscle fatigue during exercise in sports such as swimming and water polo. Objective: To evaluate various beta-alanine supplementation protocols in swimmers and water polo players and their effects on performance. Materials and methods: This study is a systematic review of various beta-alanine supplementation protocols used in exercises involving water polo and high-performance swimming, from searches on the Pubmed, SCIELO and RBNE platforms. Articles in English and Portuguese were included, which were evaluated on the basis of methods and parameters specific to swimming and water polo. Results: The review found that beta-alanine supplementation protoco...
Segundo a Lei Orgânica de Segurança Alimentar e Nutricional (Lei no 11.346, 15 de setembro de 2006)2 “é direito de todos o acesso regular e permanente a alimentos de qualidade, em quantidade suficientes, sem comprometer o acesso a outras... more
Segundo a Lei Orgânica de Segurança Alimentar e Nutricional (Lei no 11.346, 15 de setembro de 2006)2 “é direito de todos o acesso regular e permanente a alimentos de qualidade, em quantidade suficientes, sem comprometer o acesso a outras necessidades essenciais, visando garantir a segurança alimentar e cumprir o Direito Humano à Alimentação Adequada (DHAA)”. Em 2019 iniciou-se a pandemia mundial de COVID - 19, gerando aumento na crise econômica e sanitária, que afeta diretamente na qualidade alimentar da população. O presente estudo tem como objetivo analisar qualitativamente hábitos alimentares de crianças e adolescentes durante o período da pandemia, por meio de revisão sistemática da literatura. Observou-se que famílias com baixa renda tiveram perdas significativas quanto a qualidade dos alimentos consumidos ao mesmo tempo em que as crianças e adolescentes com renda familiar mais alta obteve melhora na qualidade alimentar em função da imunidade. Conclui-se que a pandemia de COVID...
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Introduction: According to the World Health Organization (WHO), infertility is defined as a failure in fertilization without any use of a contraceptive method for at least 12 consecutive months, with the individual being of reproductive... more
Introduction: According to the World Health Organization (WHO), infertility is defined as a failure in fertilization without any use of a contraceptive method for at least 12 consecutive months, with the individual being of reproductive age and having an active sexual life, where male infertility has been assuming a prominent position.This condition is considered to beof high importance in the contemporary world. Objectives:To systematically review the literature on the impactof oral zinc supplementation on male infertility and to assess whether its intake exerts a therapeutic effect, based on the evaluation of seminal parameters, according to manuals publishedby the WHO. Methodology: A systematic review was carried out by means ofa search, in the English and Portuguese languages, for original articles in the Pubmed, Science Direct, Lilacs and Scieloscientific databases. Results: The intervention groups ranged from 18 to 77 individuals and the control groups ranged from 8 to 113 ind...
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Introduction: Cardiovascular diseases are the main cause of death in the world, and some of these diseases can be controlled or avoided with a healthier lifestyle. These diseases are often associated with the emergence of other diseases... more
Introduction: Cardiovascular diseases are the main cause of death in the world, and some of these diseases can be controlled or avoided with a healthier lifestyle. These diseases are often associated with the emergence of other diseases such as diabetes mellitus, obesity, high cholesterol levels and high blood pressure. Research has shown that vitamin D deficiency can be a factor that also helps in the appearance of these diseases, since if the serum levels of vitamin D are adequate, it can help in the control and prevention of these diseases. Objectives: To evaluate the relationship between vitamin D and cardiovascular diseases, specifically systemic arterial hypertension and its effects. Methods: A systematic review was carried out by searching for original articles in scientific databases: Pubmed, Science Direct, Lilacs and Scielo in English and Portuguese. Results: No conclusive data were found for the indication of vitamin D supplementation in the treatment of systemic arterial...
Espiritualidade e religiosidade são palavras e conceitos que, apesar de possuírem significados próprios, correlacionam-se no ambiente hospitalar no contexto do cuidado com o paciente. As crenças religiosas, sejam elas quais forem,... more
Espiritualidade e religiosidade são palavras e conceitos que, apesar de possuírem significados próprios, correlacionam-se no ambiente hospitalar no contexto do cuidado com o paciente. As crenças religiosas, sejam elas quais forem, proporcionam bem-estar e contribuem para uma mudança atitudinal, suavizando as vivências traumáticas relacionando-as ao processo do cuidado com pacientes em estado grave, são também elementos que auxiliam o processo de cura. Objetivo: analisar como a fé pode ser um fator contribuinte para o tratamento dos pacientes. Metodologia: trata-se de um estudo bibliográfico qualitativo exploratória onde foram coletados artigos acerca do tema da espiritualidade no cuidado do paciente nos anos de 2010 a 2021. Resultados: observou-se que os pacientes tiveram uma melhora significativa durante os cuidados após se apoiaram na espiritualidade, embora não haja um consenso entre as equipes de cuidados de que a espiritualidade influencie positivamente na melhora. Conclusão: c...
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Introdução: O câncer é uma doença crônica multicausal, caracterizada por células anormais que se dividem incontrolavelmente e causam disfunções no tecido corporal. Com o diagnóstico comprovado, ao iniciar o tratamento, o mesmo gera um... more
Introdução: O câncer é uma doença crônica multicausal, caracterizada por células anormais que se dividem incontrolavelmente e causam disfunções no tecido corporal. Com o diagnóstico comprovado, ao iniciar o tratamento, o mesmo gera um grande impacto aos pacientes, interferindo em questões nutricionais. Dessa forma, pesquisas buscam compreender possíveis relações benéficas entre nutrientes e o câncer, tal qual a Vitamina D e o Câncer de Mama, por esta vitamina ser um regulador transcricional de vários genes envolvidos no ciclo celular, apoptose e angiogênese. Objetivos: revisar de forma sistemática artigos científicos no período de 2010 a 2021, verificando se existe relação benéfica no uso de Vitamina D em mulheres adultas com Câncer de Mama e, qual dosagem seria a ideal. Métodos: os artigos encontrados foram tabelados, ambos embasados no gênero feminino, com idade superior a 18 anos, e com análises variando de 1 mês à 9 anos. Resultados: os levantamentos mostraram que concentrações ...
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Vitamin D acts in the regulation of bone metabolism and plays actions in other tissues, being considered of extreme importance. The causes of its deficiency are multifactorial, its deficiency after bariatric surgery can cause skeletal... more
Vitamin D acts in the regulation of bone metabolism and plays actions in other tissues, being considered of extreme importance. The causes of its deficiency are multifactorial, its deficiency after bariatric surgery can cause skeletal changes, calcium deficiency, increasing the risk of malignancies (colon, breast, and prostate) and chronic inflammatory or autoimmune diseases, metabolic changes, peripheral vascular disease, muscle weakness and, osteoporosis or osteomalacia. Objective- Given the importance of this nutrient, this study was designed to analyze different types of adequate doses of vitamin D that can help in the treatment of obesity and possible pathologies after bariatric surgery. MethodsFor this, it was performed a search in the Pubmed, Scielo, and Science Direct databases, with published articles in Portuguese and English. The search strategy used the keywords individually or in association with "vitamin D", "supplementation", and "bariatric su...
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The present study aimed to review studies on anthocyanin consumption and its benefits in three of the parameters of the metabolic syndrome, namely total cholesterol, insulin resistance and blood pressure control. The articles were... more
The present study aimed to review studies on anthocyanin consumption and its benefits in three of the parameters of the metabolic syndrome, namely total cholesterol, insulin resistance and blood pressure control. The articles were selected from the SCIELO, PubMed and Science Direct databases. The descriptors that were used in English are anthocyanin, metabolic syndrome, benefits, treatment and based on these descriptors, the following word combinations were investigated: benefits of anthocyanins in metabolic syndrime, treatment of metabolic syndrome with anthocyanins. Selected 9 studies found within the parameters sought, results were obtained in 8 articles demonstrating that anthocyanins can help reduce total cholesterol, 5 proving that beneficial actions occur in decreasing insulin resistance and 6 articles emphasized that ANTs can have effects positive regarding the decrease in blood pressure. It is common to find individuals with at least 1 of the parameters of the metabolic syn...
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Atualmente, por conta da pandemia que chegou de repente, pode-se observar uma diferença na alimentação das pessoas devido ao estresse e preocupação do atual momento. Sabe-se que o estresse está envolvido com modificações no sistema... more
Atualmente, por conta da pandemia que chegou de repente, pode-se observar uma diferença na alimentação das pessoas devido ao estresse e preocupação do atual momento. Sabe-se que o estresse está envolvido com modificações no sistema neuronal, desencadeando ações do hipotálamo, que por sua vez, ocasionam mudanças no consumo alimentar de forma negativa, levando os indivíduos a consumirem alimentos mais calóricos e com maior quantidade de açúcar e gordura, levando a um aumento no ganho de peso e de doenças crônicas não transmissíveis (DCNT). Evidências também demonstram o efeito do estresse no comportamento alimentar dos indivíduos, interferindo no metabolismo de vários nutrientes. Portanto, a alimentação vem mostrando sua grande relevância e importância, cada vez maior em relação aos benefícios à saúde, auxiliando na diminuição dos fatores de riscos para determinadas doenças. Diante do exposto, o presente estudo teve como objetivo analisar através de uma revisão bibliográfica, o compor...
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Orientadores: Liliana Aparecida Lucci de Angelo Andrade, Fatima Aparecida Böttcher-LuizTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: A invasão do endométrio pelo trofoblasto extraviloso é... more
Orientadores: Liliana Aparecida Lucci de Angelo Andrade, Fatima Aparecida Böttcher-LuizTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: A invasão do endométrio pelo trofoblasto extraviloso é fundamental no desenvolvimento do feto e da placenta, processo este controlado por fatores ligados à atividade imunológica e hormonal que, quando alterada, pode resultar em interrupção da gestação e/ou geração das chamadas doenças trofoblásticas gestacionais. Em algumas situações, pode haver evolução para o coriocarcinoma, neoplasia maligna do trofoblasto, em que há evidências da atuação das moléculas ligadas ao processo de fusão celular e inflamação. Porém, os estudos neste tema são incipientes e inconclusivos. Considerando essas informações, o objetivo deste trabalho é estudar de forma comparativa a expressão das citocinas LIF, IL-6 e do ativador de transcrição STAT-3, além da telomerase, em material de aborto, de placenta normal a termo e de coriocarc...
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Metastasis is the main cause of death in cancer patients; it requires a complex process of tumor cell dissemination, extra cellular matrix (ECM) remodeling, cell invasion and tumor-host interactions. Collagen is the major component of... more
Metastasis is the main cause of death in cancer patients; it requires a complex process of tumor cell dissemination, extra cellular matrix (ECM) remodeling, cell invasion and tumor-host interactions. Collagen is the major component of ECM; its fiber polymerization or degradation evolves in parallel with the evolution of the cancerous lesions. This study aimed to identify the collagen content, spatial
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A vitamina D atua na regulação do metabolismo ósseo e desempenha ações em outros tecidos, sendo considerada de extrema importância. As causas de sua deficiência são multifatoriais e, sua deficiência após a cirurgia bariátrica pode causar... more
A vitamina D atua na regulação do metabolismo ósseo e desempenha ações em outros tecidos, sendo considerada de extrema importância. As causas de sua deficiência são multifatoriais e, sua deficiência após a cirurgia bariátrica pode causar alterações esqueléticas,deficiência de cálcio, aumentando o risco de malignidades (de cólon, mama e próstata) e,doenças inflamatórias crônicas ou autoimunes, alterações metabólicas, doença vascular periférica, fraqueza muscular e, osteoporose ou osteomalácia. Objetivo: Dada a importância desse nutriente, o objetivo deste este estudo foi analisar diferentes tipos de dosagens adequadas de vitamina D que possam auxiliar no tratamento da obesidade e possíveis patologias após a cirurgia bariátrica. Métodos: Para tanto, foi realizada uma pesquisa na base de dados PubMed, Scielo e Science Direct, com artigos publicados em português e inglês. A estratégia de busca utilizou as palavras-chaves individualmente ou em associação “vitamina D”, “suplementação”, “c...
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Introduction: Eating disorders can cause numerous problems for the physiology of the female body and consequences, such as infertility and difficulties during pregnancy and childbirth, can occur if they are present during a woman's... more
Introduction: Eating disorders can cause numerous problems for the physiology of the female body and consequences, such as infertility and difficulties during pregnancy and childbirth, can occur if they are present during a woman's reproductive age. Objective: The objective of this research was to analyze the impacts for mother and child that may be somehow related to the nutritional deficiency, whether active or not, of these women. Methodology: The methodology used was a bibliographic survey in the platforms PubMed, BIREME, SCIELO, using combinations of the following keywords in English: Eating Disorder AND Pregnancy, Anorexia, Bulimia. Result: According to the studies analyzed, the existence of some type of eating disorder, whether active or not, had a negative impact on the pregnancies of these women. Miscarriages, stillborn babies, premature birth, premature placental displacement, small newborn gestational age, umbilical cord knots and even neurological deficits could occu...
Gas cromatography with mass spectrometry detection coupled to headspace solid-phase microextraction (SPME) was used to analyse the aroma profile of saffron (Crocus sativus L.). The influence of the saffron amount and form (intact stigmas... more
Gas cromatography with mass spectrometry detection coupled to headspace solid-phase microextraction (SPME) was used to analyse the aroma profile of saffron (Crocus sativus L.). The influence of the saffron amount and form (intact stigmas vs. powder) on the intensity of the chromatograms was preliminarily evaluated. Moreover, the mutual effects of the sample temperature and exposition time of a polydimethylsiloxane SPME fiber was investigated by response surface methodology. Saffron samples produced in L’Aquila (Italy), Iran and Morocco, and commercial spices were analysed under application of the optimised SPME conditions and geographical classification was attempted by linear discriminant analysis applied to the relative peak areas of all the detected volatiles. The spices produced in the different geographical areas and the commercial products were discriminated with good accuracy, 91% of external samples being correctly classified using leave-one-out cross-validation. An acceptable differentiation (73% of correct predictions) was obtained by considering only the major aroma components.
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A invasao do endometrio pelo trofoblasto extraviloso e fundamental no desenvolvimento do feto e da placenta, processo este controlado por fatores ligados a atividade imunologica e hormonal que, quando alterada, pode resultar em... more
A invasao do endometrio pelo trofoblasto extraviloso e fundamental no desenvolvimento do feto e da placenta, processo este controlado por fatores ligados a atividade imunologica e hormonal que, quando alterada, pode resultar em interrupcao da gestacao e/ou geracao das chamadas doencas trofoblasticas gestacionais. Em algumas situacoes, pode haver evolucao para o coriocarcinoma, neoplasia maligna do trofoblasto, em que ha evidencias da atuacao das moleculas ligadas ao processo de fusao celular e inflamacao. Porem, os estudos neste tema sao incipientes e inconclusivos. Considerando essas informacoes, o objetivo deste trabalho e estudar de forma comparativa a expressao das citocinas LIF, IL-6 e do ativador de transcricao STAT-3, alem da telomerase, em material de aborto, de placenta normal a termo e de coriocarcinoma. Metodos: a expressao destas moleculas foi avaliada pelos metodos: imunoistoquimica (IHQ), imunofluorescencia (IF), Western Blotting (WB) e Real-Time PCR (RT-PCR), em amost...
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INTRODUCTION Preeclampsia (PE) is a pregnancy complication associated with increased maternal and perinatal morbidity and mortality. The disease presents with recent onset hypertension (after 20 weeks of gestation) and proteinuria, and... more
INTRODUCTION Preeclampsia (PE) is a pregnancy complication associated with increased maternal and perinatal morbidity and mortality. The disease presents with recent onset hypertension (after 20 weeks of gestation) and proteinuria, and can progress to multiple organ dysfunction, with worse outcomes among early onset preeclampsia (EOP) cases (< 34 weeks). The placenta is considered the root cause of PE; it represents the interface between the mother and the fetus, and acts as a macromembrane between the two circulations, due to its villous and vascular structures. Therefore, in pathological conditions, macroscopic and microscopic evaluation can provide clinically useful information that can confirm diagnosis and enlighten about outcomes and future therapeutic benefit. OBJECTIVE To perform an integrative review of the literature on pathological placental findings associated to preeclampsia (comparing EOP and late onset preeclampsia [LOP]) and its impacts on clinical manifestation...
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Blastocyst implantation and neoplastic invasion have some common properties related to tissue invasion, mediated by various cytokines. Aim To compare the expression of IL-6, STAT-3 and telomerase in material of abortions in the first... more
Blastocyst implantation and neoplastic invasion have some common properties related to tissue invasion, mediated by various cytokines. Aim To compare the expression of IL-6, STAT-3 and telomerase in material of abortions in the first trimester of pregnancy, at term placentas and in choriocarcinomas. Methods Immunohistochemical reactions were performed on formalin fixed and included in paraffin samples from 3 groups: abortions, normal at term placentas and choriocarcinomas. Western Blot and Real-Time PCR assays were performed on fresh material from BeWo cell line and in primary culture cells of normal placenta. Results Immunohistochemical reactions: IL-6 expression was moderate in the first trimester abortion samples and high in at term placentas and choriocarcinomas. STAT-3 was strongly positive in all groups. Telomerase expression was absent in normal at term placentas but was increased in BeWo cells. Conclusion IL-6 and STAT-3 are present in the invasion process of the normal plac...
Research Interests: Materials Engineering, Biomedical Engineering, Scanning Electron Microscopy, Polymers, Atomic Force Microscopy, and 13 moreHumans, Clinical research, Poly (lactic acid), Poly (glycolic acid)a, Female, Animals, Plasticizers, Biodegradable Polymer, Rats, Time Factors, Wistar Rats, Biocompatible Materials, and Lactic Acid
Research Interests: Biomedical Engineering, Nonlinear Optics, Ovarian Cancer, Extracellular Matrix, Biomedical, and 15 moreBiomedical Optics, Humans, Collagen, Female, Optical microscopy, Optical physics, Aged, Middle Aged, Optometry and Ophthalmology, Epithelial cells, Adult, Analysis of Variance, Equipment Design, Harmonic Generation, and hematoxylin and eosin
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To determine whether the plasma concentration of vascular endothelial growth factor (VEGF) is elevated after a common surgical procedure, and if any increase is followed by a reduction in the amount of infused crystalloid fluid in the... more
To determine whether the plasma concentration of vascular endothelial growth factor (VEGF) is elevated after a common surgical procedure, and if any increase is followed by a reduction in the amount of infused crystalloid fluid in the blood. Nonrandomized study. Experimental group age-matched to control group. Operating room of a large medical research center. 10 ASA physical status I, II, and III patients, aged 51 to 94 years, scheduled for hip surgery; and 10 ASA physical status I and II volunteers, aged 53 to 71 years, comprising a control group. Patients and control subjects were given an intravenous volume load of Ringer&amp;amp;amp;amp;#39;s acetate solution (12.5 mL/kg for 30 min). The plasma concentrations of C-reactive protein, interleukin-6, interleukin-8 (inflammatory parameters used as biochemical evidence of trauma), and VEGF were measured in patients the morning after the day of the surgery. The area under the curve (AUC) for the plasma dilution was calculated in response to the intravenous fluid. VEGF concentration was tripled in the hip group (100.7 +/- 18.5 pg/L vs. 31.9 +/- 7.2 pg/L; p &amp;amp;amp;amp;lt; 0.001) as a consequence of the trauma of surgery. The other inflammatory parameters were also significantly increased. There was no difference in AUC between the two groups during infusion, but after infusion AUC was significantly increased in the hip group versus controls (4.88 vs. 2.8; p = 0.025), suggesting persistence of the infused fluid to remain in the vasculature. AUC was not highly correlated with any of the inflammatory parameters regardless of group during or after infusion. Intravascular persistence of infused crystalloid is increased after hip surgery despite elevated VEGF levels in plasma.