Natasha October

Kaempferide was isolated from the ethyl acetate fraction of the aqueous ethanol extract of Thesium viride (Santalacea), a plant used in traditional medicine for the treatment of jaundice and ulcer using a combination of silica gel column chromatography and preparative TLC. The structure of this compound was elucidated using NMR spectroscopic analysis and by comparison with reported data. This is the first report of isolation of this compound from this plant. The antimicrobial activity of n-hexane, chloroform, ethyl acetate and n-butanol fractions was determined on some gram negative, gram positive bacteria and fungi. The ethyl acetate fraction was found to have higher inhibitory effect to the test microorganisms.

ABSTRACT (Chemical Equation Presented) The synthesis, cytotoxicity, and antimalarial activity of resistance-reversing bifunctional dihydropyrimidone-chloroquinoline conjugates are reported herein. In vitro assay results indicate this class of compounds is highly active against both chloroquine-resistant and chloroquine-sensitive strains of P. falciparum.