Objective To assess the efficacy of tacrolimus and clobetasol propionate in the treatment of alopecia areata. Methods A clinical trial was carried out in the department of Dermatology and Venereology, Dhaka Medical College Hospital,... more
Objective To assess the efficacy of tacrolimus and clobetasol propionate in the treatment of alopecia areata. Methods A clinical trial was carried out in the department of Dermatology and Venereology, Dhaka Medical College Hospital, Dhaka, Bangladesh from May 2013 to April 2014. Total sixty patients were enrolled and divided into group A and group B. Thirty of group A patients were treated with topical tacrolimus and thirty of group B patients were treated with topical clobetasol propionate. Results In group A, the duration of illness ranged from 2 months to 36 months and in group B, from 1 month to 24 months. Among the patients of group A and B, 25 (83.3%) and 27 (90%) patients improved, respectively. After 16th week of treatment, slight response in 6 (20%) and 4 (13.3%) and moderate response in 18 (59.4%) and 22 (63.2%) and marked response in 1 (3.3%) and 1 (3.3%) was seen in group A and group B, respectively. No significant difference was observed ( p value = 0.648). Conclusion B...
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Objective To correlate the clinical patterns of onychomycosis with the type of mycological agents in onychomycosis. Patients and methods In this cross-sectional study, 120 patients with onychomycosis, attending outpatient department, were... more
Objective To correlate the clinical patterns of onychomycosis with the type of mycological agents in onychomycosis. Patients and methods In this cross-sectional study, 120 patients with onychomycosis, attending outpatient department, were selected by purposive type of sampling technique. They were subjected to thorough clinical examination. Nail material was collected for mycological diagnosis by microscopy and culture on dermatophyte test medium. Results Microscopy was positive in 47 (39.2%) cases, whereas culture yielded Trichophyton rubrum in 53 (44.2%) and T. mentagrophytes in 2 (1.7%) patients. Common clinical nail changes in mycologically proven cases were thickening of nail plate (68.9%), subungual hyperkeratosis (63.9%), onycholysis (55.7%), roughening of nail plate (29.5%), yellowish discoloration (29.5%) and brownish-yellow discoloration (21.3%). Only, subungual hyperkeratosis was found significantly more in mycologically positive cases (63.9%) than in mycologically negati...
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Introduction In recent times, condylomata acuminata has emerged as a disease of major public concern because of its high prevalence, sexual mode of transmission, its association with various neoplasia and HIV, difficulty in treatment and... more
Introduction In recent times, condylomata acuminata has emerged as a disease of major public concern because of its high prevalence, sexual mode of transmission, its association with various neoplasia and HIV, difficulty in treatment and high rates of recurrence. Imiquimod is effective in the treatment of condylomata acuminata but there is paucity of data regarding its side effect and its comparison with established treatment method-cryotherapy. Objective The aim of this study was to compare the safety level of Imiquimod vs cryotherapy in the treatment of condylomata acuminata. Patients and Methods A randomized controlled clinical trial was conducted from April 2019 to March 2020 in the Department of Dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Primarily 64 patients were enrolled in this study and randomized by lottery method into group A and Group B and patients of group A was treated with Imiquimod and patients of group ...
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Objective To compare the efficacy of combination of intralesional corticosteroid injection and cryotherapy with intralesional corticosteroid injection alone in patients of keloid. Methods A clinical trial was carried out in the department... more
Objective To compare the efficacy of combination of intralesional corticosteroid injection and cryotherapy with intralesional corticosteroid injection alone in patients of keloid. Methods A clinical trial was carried out in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh for duration of January 2013 to August 2013. About 30 patients (group A) were treated with intralesional triamcinolone acetonide with cryotherapy and 30 patients (group B) were treated with intralesional triamcinolone acetonide. Results Improvement rate was highest for the lesions on the chest, which was 18 (34.6%) and lowest for back 3 (5.8%). Out of all patients from group A, the mean size of the lesions were 8.17cm, 5.90 cm, 4.32 cm, and 3.57 cm at 1st visit, 2nd visit, 3rd visit and 4th visit, respectively. In group B, the mean size of the lesions was 7.50 cm, 4.92 cm, 3.00 cm, and 4.75 cm at 1st visit, 2nd visit, 3rd visit and 4th visit, resp...
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A controlled clinical trial was conducted in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh to compare the side-effects of adapalene and benzoyl peroxide combination... more
A controlled clinical trial was conducted in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh to compare the side-effects of adapalene and benzoyl peroxide combination gel with adapalene monotherapy and benzoyl peroxide monotherapy in the treatment of acne vulgaris. The study conducted in sixty patients. Group A (case) 20 patients were treated with adapalene and benzoyl peroxide combination gel, group B (control) 20 patients were treated with topical adapalene and group C (control) 20 patients were treated with topical benzoyl peroxide. The side effects experienced by patients of different groups in their first follow up were noticed. In group A - erythema, scaling, dryness, burning and pruritus were present in 45%, 10%, 35%, 40% and 10% of patients and in group B, 35%, 25%, 30%, 35% and 15% respectively. However in group C dryness and pruritus were absent in all the patients and the erythema, scaling and burning w...
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Background: Computed tomography (CT) is the gold standard for exact delineation of paranasal sinus(PNS) disease. There are many radiologically important diseases of paranasal sinuses. Objective: to evaluate the malignant PNS mass by... more
Background: Computed tomography (CT) is the gold standard for exact delineation of paranasal sinus(PNS) disease. There are many radiologically important diseases of paranasal sinuses. Objective: to evaluate the malignant PNS mass by computed tomographic image and the findings of this modality were compared with histopathological result.Methods: It was a cross sectional type of study and carried out with suspected PNS mass having patients during January 2009 to October 2010.Results: The mean age of the patients was 35.95 ± 18.24 and common complaints of the patients were nasal obstruction (73.7%) and maximum 53.9% patients had PNS mass in maxillary sinuses. Out of 76 cases 21.1 % found malignant mass on CT and after histopathology 19. 7% had malignant mass. Out of all cases 14 were diagnosed as malignant PNS mass by CT scan and confirmed by histopathological evaluation and they were true positive. Two cases were diagnosed as malignant PNS mass by CT scan but not confirmed by histop...
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A cross sectional study was carried out in the department of Obstetrics and Gynae of Dhaka Medical College Hospital (DMCH). Two hundred thirty two cases who fulfilled the inclusion criteria were studied. This study aimed to assess the... more
A cross sectional study was carried out in the department of Obstetrics and Gynae of Dhaka Medical College Hospital (DMCH). Two hundred thirty two cases who fulfilled the inclusion criteria were studied. This study aimed to assess the outcome of implementation of WHO modified partograph in labour management with special interest to evaluate the fetomaternal outcome. Among the 232 cases, engaged fetal head had more vaginal delivery, 78.8% than unengaged head. The rate of caesarean section was 26.9% in women with unengaged head vs 11.5% in women with engaged head in this study. This study showed that there was no LUCS when cases remained within alert line and outside the action line in partograph all were delivered by caesarean section. The rate of spontaneous delivery was more 58.6% who did not require any augmentation. On the other hand 80 percent cases of LUCS needed augmentation. In this study, 84.1 percent babies cried spontaneously, 12.9 percent cried after resuscitation and onl...
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Computed tomography (CT) is the gold standard for exact delineation of paranasal sinus(PNS) disease. There are many radiologically important diseases of paranasal sinuses. Objective of the study was to evaluate the role of computed... more
Computed tomography (CT) is the gold standard for exact delineation of paranasal sinus(PNS) disease. There are many radiologically important diseases of paranasal sinuses. Objective of the study was to evaluate the role of computed tomographic image(CT) in the diagnosis of nasopharyngeal angiofibroma. A cross sectional study was carried out in the department of Radiology & Imaging, Bangabandhu Sheikh Mujib Medical University(BSMMU), Dhaka in collaboration with department of Otolaryngology and department of Pathology of BSMMU. This study was carried out with patients having suspected PNS mass and the duration of the study was from January 2009 to October 2010. Maximum 30.3% patients were belonged to 46 to 60 years age group and of them maximum 73.7% had complaints of nasal obstruction. Maximum 53.9% patients had PNS mass in maxillary sinuses and out of all cases 8 were diagnosed as having nasopharyngeal angiofibroma by CT scan and confirmed by histopathological evaluation. Two cases ...
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A cross sectional study carried out with patients having suspected paranasal sinus (PNS) mass during January 2009 to October 2010 to evaluate the fungal diseases in PNS by computed tomographic(CT) image and comparison of the findings of... more
A cross sectional study carried out with patients having suspected paranasal sinus (PNS) mass during January 2009 to October 2010 to evaluate the fungal diseases in PNS by computed tomographic(CT) image and comparison of the findings of this modality with histopathological result. Among the total 76 patients, the mean age of the patients was 35.95 ± 18.24 and common complaints of the patients were nasal obstruction (73.7%) and maximum 53.9% patients had PNS mass in maxillary sinuses. Out of all cases 10 were diagnosed as having fungal infection/mass by CT scan and confirmed by histopathological evaluation. Two cases were diagnosed as having fungal infection/mass by CT scan but not confirmed by histopathological findings. Of 64 cases of other than fungal infection/mass, which were diagnosed by CT scan, six were confirmed as having fungal infection/mass and 58 were other than having fungal infection/mass by histopathology. Sensitivity of CT scan to diagnose fungal infection/mass was 6...
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Anhidrosis is the inability of the body to produce and /or deliver eccrine sweat to the skin surface in response to an appropriate stimulus or environment. It may be due to changes in the eccrine sweat gland, alterations in the nervous... more
Anhidrosis is the inability of the body to produce and /or deliver eccrine sweat to the skin surface in response to an appropriate stimulus or environment. It may be due to changes in the eccrine sweat gland, alterations in the nervous pathway or due to metabolic, endocrine or systemic disease. Purely psychogenic anhidrosis is also known. Occasionally it may not be possible to identify the cause. It may be localized, generalized, partial or complete. Extensive anhidrosis may impair heat regulation and produce heat exhaustion. The pathogenesis and underlying lesion of acquired idiopathic generalized anhidrosis (AIGA) are apparently heterogeneous. Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder in which systemic anhidrosis occurs in the absence of any causative skin, metabolic or neurological disorder. Congenital insensitivity to pain and anhidrosis (CIPA), also known as hereditary sensory and autonomic neuropathy type III is an autosomal recessive disorder charac...
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DOI: http://dx.doi.org/10.3329/bmj.v41i3.18950Bangladesh Medical Journal 2012 Vol.41(3): 7
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Research Interests: Medicine and Population
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A cross sectional study, conducted in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU) for duration of January 2009 to December 2010. Hundred twenty patients with onychomycosis were... more
A cross sectional study, conducted in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU) for duration of January 2009 to December 2010. Hundred twenty patients with onychomycosis were selected by purposive type of nonprobability sampling technique. Majority of the patients 61(150.8%) were in the age group of 21-30 years old. Mean age of the patients were 32.8±14 years and most of the patients were house wives 36(30.0%). Disfigurement 117(97.5%) and discomfort 89(74.2%) were more common chief complaints of the patients. The mean duration of disease was 20.4±15.4 months and nail fold changes were associated with 37(30.8%) patients and more than a half 63(52.5%) of the patients had history of wet works. Regarding the history of past illness, it was observed that previous onychmycosis found 26(21.7%), nail trauma 26(21.7%) and immune suppression 6(5.0%). In endocrinopathies, hypothyroidism was observed in 1(0.8%), Diabete...
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Vitiligo is an acquired skin disorder characterized by welldefined white patches that are often symmetrically distributed. The study was conducted to compare the efficacy of the combination of topical betamethasone dipropionate and... more
Vitiligo is an acquired skin disorder characterized by welldefined white patches that are often symmetrically distributed. The study was conducted to compare the efficacy of the combination of topical betamethasone dipropionate and calcipotriene with betamethasone dipropionate and calcipotriene alone in the treatment of localized vitiligo. A clinical trial was carried out with the patients of vitiligo from January 2012 to August 2012. In group A, 20 patients were applied betamethasone dipropionate cream 0.05% and topical calcipotriene ointment (0.005%), in group B, 20 patients were applied betamethasone dipropionate cream 0.05% only; In group C, 20 patients were applied calcipotriene ointment 0.005% alone. From base line percentage reduction of total lesion in 1st follow up in group A, group B and group C were 20%, 15% and 10% respectively. At 3rd follow up in group A, group B and group C it was 50%, 37% and 30% and at 5th follow up, it was 80%, 75% and 65% respectively. ANOVA test ...
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Verruca or warts are common significant cause of cosmetic concern and frustration of the patient. Social activities may be affected. Verruca are formed by benign proliferations of the skin and mucosa that are caused by infection with ... more
Verruca or warts are common significant cause of cosmetic concern and frustration of the patient. Social activities may be affected. Verruca are formed by benign proliferations of the skin and mucosa that are caused by infection with Human papilloma virus (HPV). These viruses do not produce acute signs or symptoms but induce a slow, focal expansion of epithelial cells. There are 100 types of Human papilloma virus (HPV). The natural history of common warts is for most of them to spontaneously resolve. But lesions are sometime uncomfortable. Warts typically continue to increase in size and distribution and may become more resistant to treatment over time. A significant proportion of women with genital HPV infection develops low-grade cervical lesions. Most of these low-grade lesions regress spontaneously; one study suggests that approximately 15 percent progress to high-grade cervical lesions within two years. High-grade cervical lesions have a strong malignant potential; one s...
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A cross sectional study of thirty eight vitiligo patients attending at the outpatients was conducted. The result revealed generalized presentation in 53.6% cases followed by focal presentation, acro-facial and segmented presentation which... more
A cross sectional study of thirty eight vitiligo patients attending at the outpatients was conducted. The result revealed generalized presentation in 53.6% cases followed by focal presentation, acro-facial and segmented presentation which were 26.3% cases, 15.8%cases and 5.3% cases. Progressive type was found in majority of cases which were 71.1% cases followed by stable case which was 39.9% cases and positive family history was found in 36.8% cases in our study. Among 38 vitiligo patients highest number of associated autoimmune disease was the thyroid abnormalities of which hypothyroidism was 15.8% and hyperthyroidism was 7.9% cases respectively. Diabetes mellitus was found in 2.6% cases, Addisons disease and SLE were found in 2.6%case each. No autoimmune disease was found in the rest 68.5% cases. DOI: http://dx.doi.org/10.3329/cbmj.v2i2.16700 Community Based Medical Journal 2013 July: Vol.02 No 02: 57-61
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Background: Transvaginal sonography is superior to transabdominal sonography in most cases of pelvic pathology. Objective: This study was undertaken to see the clinicalpathological characteristics of endometrial hyperplasia. Methodology:... more
Background: Transvaginal sonography is superior to transabdominal sonography in most cases of pelvic pathology. Objective: This study was undertaken to see the clinicalpathological characteristics of endometrial hyperplasia. Methodology: This cross sectional study was carried out from January 2007 to December 2008 for a period of two years. All suspected cases of endometrial hyperplasia were included for this study. Transvaginal sonography (TVS) performed and confirmation was done by histopathological examination. Result: A total number of 40 cases were enrolled for this study. The most common diagnosed endometrial pathology was endometrial hyperplasia which was 42.5% cases. Endometrial polyp was diagnosed in 32.5% cases. Endometrial carcinoma was in 7.5% patients and submucosal fibroid was in 10.0%. Conclusion: Endometrial hyperplasia is the most common disease among the women presented with endometrial pathology. DOI: http://dx.doi.org/10.3329/jssmc.v5i1.16198 J Shaheed Suhrawardy...
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Animal bite is common in Bangladesh. A cross sectional type of descriptive study was carried out at the Institute of Public Health (IPH), Dhaka to find out the knowledge and practices related to wound care among animal bite cases ... more
Animal bite is common in Bangladesh. A cross sectional type of descriptive study was carried out at the Institute of Public Health (IPH), Dhaka to find out the knowledge and practices related to wound care among animal bite cases during the month of February, 1998. A total of 200 patients were interviewed, 55% of them came from urban area. Maximum (65.5%) patients were teenagers and adult (above 13 yrs.) with mean age 22.15 yrs. Male and female ratio was 80.5:19.5. Majority of cases were poor (76.5%) and only 12% attained educational level of SSC pass or above. In 92.5% cases dog was the biting animal, 60% of which were stray. Only 91(45.5%) patients took immediate measures for wound care. Of them only 11 patients knew and washed the wound by soap and water and 3 patients did it after getting advice from physicians. 134 (67%) patients consulted with physicians one hour to several days after, whereas 33% within one hour. Among the attending physicians 31.5% were MBBS...
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Endometriosis is a common cause of pelvic pain and infertility in young women. Transvaginal sonography is major means for diagnosing ovarian masses. In our study, we scanned 60 patients with endometriomata who underwent laparotomy or... more
Endometriosis is a common cause of pelvic pain and infertility in young women. Transvaginal sonography is major means for diagnosing ovarian masses. In our study, we scanned 60 patients with endometriomata who underwent laparotomy or laparoscopy. We compared preoperative ultrasonographic diagnosis with histological reports. The sonographic criteria for the diagnosis of endometriomata were (1) cystic structure with low, homogeneous echogenicity and (2) thick cystic wall with regular margins. In 50 patients, sonography suggested an endometrioma. In 47 cases, the diagnosis was correct. The false‐positive cases were all caused by cystic teratomas with a homogeneous sonographic pattern. Ten false‐negative cases were diagnosed by ultrasonography as functional ovarian cysts (5), teratomas (3), and benign ovarian cystoma (1). Only 1 case of a 5‐mm endometrioma was demonstrated by laparoscopy but not by TVS. The sensitivity of TVS for diagnosing endometriomata was 82.4% and specificity 97.7%...
Research Interests: Radiology, Adolescent, Medicine, Prospective studies, Humans, and 15 moreFemale, Clinical, Clinical Sciences, Middle Aged, Adult, Endometriosis, Ovarian cysts, Teratoma, Sensitivity and Specificity, Laparoscopy, Predictive value of tests, Laparotomy, Cystadenoma, transvaginal sonography, and Ovarian Neoplasms
Address for correspondence Dr. Lubna Khondker, Assistant Professor, Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh. E-mail: lubna_derma@yahoo.com ... Pulse dose of oral... more
Address for correspondence Dr. Lubna Khondker, Assistant Professor, Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University Shahbag, Dhaka, Bangladesh. E-mail: lubna_derma@yahoo.com ... Pulse dose of oral itraconazole is ...
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Background: Acne is a multifactorial disease and represents a spectrum of disease severity from a couple of blackheads and pustules to severe nodulocystic fulminant acne. The severity of the disease differs from patient to patient and... more
Background: Acne is a multifactorial disease and represents a spectrum of disease severity from a couple of blackheads and pustules to severe nodulocystic fulminant acne. The severity of the disease differs from patient to patient and treatment must therefore be tailored to the ...
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This study looked into the relationship between the histology and clinical characteristics of burning mouth syndrome (BMS). Individuals who experienced BMS symptoms for a minimum of six months underwent clinical and histological... more
This study looked into the relationship between the histology and clinical characteristics of burning mouth syndrome (BMS). Individuals who experienced BMS symptoms for a minimum of six months underwent clinical and histological evaluations. Preliminary assessments included recording mean age, diabetes mellitus, menopausal status, length of non-irritable and irritative salivation or symptoms, and oral hygiene. Clinical trials were conducted on the following conditions: headache, pain, non-specific health issues, taste, thirst, dry mouth, and severe menopausal symptoms. Blood tests for HBS Ag, CBC and S. Iron, S. Ferritin, S. Folic acid as well as testing for female hormones including iron, folic acid, TSH, FT3, T4, and estrogen, were among the laboratory tests. The tongue is subjected to a prospective, blind histological examination, and mucosal samples are prepared for light microscopy. The Statistical Package of Social Science (SPSS) version 23 computer statistical program (SPSS Inc. Chicago, USA) was used to compile the data that had been gathered. The tongue and oral mucosa were examined for variations in their histological and clinical characteristics using the Chi Squire and Student's t-tests; p-values less than 0.05 are regarded as statistically significant. In summary, BMS is linked to xerostomia, altered taste on laboratory examination, physical and psychological stress, and histological characteristics that may indicate a source of neuropathy.
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Lymphomatoid papulosis (LyP) is a rare cutaneous condition characterized by chronic, recurrent, and self-regressing papulonodular skin eruptions. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders, along... more
Lymphomatoid papulosis (LyP) is a rare cutaneous condition characterized by chronic, recurrent, and self-regressing papulonodular skin eruptions. It belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders, along with primary cutaneous anaplastic large cell lymphoma (primary C-ALCL) with which it shares overlapping clinical and histopathologic features. The occurrence of LyP is extremely rare, with an estimated overall prevalence rate of 1.2 to 1.9 cases per 1 million population. Patients with LyP are at an increased risk of developing cutaneous or nodal lymphoid malignancies such as classic mycosis fungoides, ALCL, and Hodgkin lymphoma. Treatment includes use of topical steroids with or followed by phototherapy (psoralen-UVA light therapy [PUVA]) or oral low-dose methotrexate (MTX). Complications due to long-term treatment may also include a higher incidence of non-melanoma skin cancer (due to PUVA) or hepatic fibrosis (due to MTX). Here, we report a case of...
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Background Dermatophytoses are becoming increasingly unresponsive to topical conventional antifungals now a days. Sertaconazole is a new, broad spectrum, fungicidal and fungistatic imidazole with added antipruritic and anti-inflammatory... more
Background Dermatophytoses are becoming increasingly unresponsive to topical conventional antifungals now a days. Sertaconazole is a new, broad spectrum, fungicidal and fungistatic imidazole with added antipruritic and anti-inflammatory activity that may be beneficial in efficacy and improving the quality of life for patients with dermatophytoses. Objective To assess the efficacy and safety of topical sertaconazole cream in the treatment of localized tinea corporis and tinea cruris. Methods A prospective, clinical trial was conducted with 81 cases of dermatophytosis patients attending outpatient department (OPD) of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Patients were advised to apply sertaconazole cream 2 times per day for 4 weeks and patients were followed up for clinical improvement and side-effects of drug therapy. Results The improvement of clinical score was from baseline to 41.6% at week 1; 89.3% at week 2 and 91.5%...
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Background Melasma is a common acquired macular hyperpigmentation which involves mostly the sun exposed areas of face and neck. Objective To assess the efficacy of the combination of 20% azelaic acid with 0.05% tretinoin cream in the... more
Background Melasma is a common acquired macular hyperpigmentation which involves mostly the sun exposed areas of face and neck. Objective To assess the efficacy of the combination of 20% azelaic acid with 0.05% tretinoin cream in the treatment of melasma. Patients and methods 30 patients of melasma were treated with daily night appl ication of 20% azelaic acid and 0.05% tretinoin. Patients were assessed at 4, 8 and 12 weeks of treatment using melasma area severity index. Side effects during therapy we re also noted. Results Majority i.e. 43% cases were between 26 to 30 years, 73.3% of patients were females and 56.7% were housewives, 70% were married and 86.7% were in middle class. Family history of melasma was positive in 66.7% cases. 93.3% patients had no hi story of systemic drug and 73.3% had no history of use of cosmetics. 93.3% of patients had m alar area involvement and 6.7% had centrofacial area involvement. After treatment, the avera ge MASI score decreased by 38.66% indicat...
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Objective To compare the efficacy of mometasone furoate and tacrolimus in the treatment of atopic dermatitis. Methods Sixty patients of atopic dermatitis were treated with mometasone furoate 0.1% (n=30) and tacrolimus 0.03% (n=30). Both... more
Objective To compare the efficacy of mometasone furoate and tacrolimus in the treatment of atopic dermatitis. Methods Sixty patients of atopic dermatitis were treated with mometasone furoate 0.1% (n=30) and tacrolimus 0.03% (n=30). Both treatments were applied twice daily for 12 weeks. Patients were followed up monthly. The disease severity assessed by SCORAD index. A 4-point scale was used to measure the level of response to treatment. Results Before treatment the respective mean SCORAD was 30.57±13.62 and 30.90±17.17 in group A and B and at the end of treatment decreased to 11.87±12.04 and 11.20±13.85, respectively ( p >0.05). Percent reduction of severity from baseline to final follow-up was 69.20±23.41 in group A and 74.77±23.30 in group B ( p =0.360). At final follow-up 56.7% of group A and 63.3% of group B achieved excellent response, 13.3% of group A and 16.7% of group B achieved good response. Conclusion We conclude that both treatments, mometasone furoate and tacrolimus,...
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Objective To compare the adverse effects of low-dose oral prednisolone and oral mini pulse dexamethasone in patients of vitiligo. Methods A clinical trial was carried out from January 2013 to December 2013. Total sixty patients of... more
Objective To compare the adverse effects of low-dose oral prednisolone and oral mini pulse dexamethasone in patients of vitiligo. Methods A clinical trial was carried out from January 2013 to December 2013. Total sixty patients of vitiligo were enrolled and 30 of group A patients were treated with low dose oral prednisolone (0.3 mg/kg body weight) daily and 30 of group B patients were treated with oral dexamethasone pulse therapy (10 mg per week) for 16 weeks. Results During 12 week follow-up, increased body weight, headache, dyspepsia and fatigue were more frequent in group A as compared to group B. Similarly, in group A other side effects noted were acne (33.3%), mooning of face (26.6%), striae (26.6%), hypertrichosis 13.2%, purpura (6.7%) and among the female patients, menstrual abnormality (71.4%) whereas in group B, no patient developed these problems from baseline to follow- up period (p<0.05). Conclusion Low dose oral prednisolone was found to be associated with more adver...
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Tuberculosis is a serious infection that affects many people worldwide, with a recent increasing prevalence especially in high-risk patients, such as HIV infection, intravenous drug abuse, diabetes mellitus, immunosuppressive therapy,... more
Tuberculosis is a serious infection that affects many people worldwide, with a recent increasing prevalence especially in high-risk patients, such as HIV infection, intravenous drug abuse, diabetes mellitus, immunosuppressive therapy, malignancies, end-stage renal disease, and and/or with multiple comorbidities. Although the incidence of Cutaneous Tuberculosis (CTB) is rare, it should be considered in patients presenting with atypical skin lesions suggestive of an underlying infectious etiology. Most often TB is an airborne transmissible disease with skin manifestations presenting as a result of hematogenous spread or direct extension from a latent or active foci of infection. However, primary inoculation may occur as a direct introduction of the mycobacterium into the skin or mucosa of a susceptible individual by trauma or injury. Although rare, it is important for clinicians to recognize the many clinical variants of CTB to prevent missed or delayed diagnoses. It is imperative th...
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Objective To assess the efficacy of benzoyl peroxide and clindamycin combination therapy with benzoyl peroxide alone in the treatment of acne vulgaris. Methods A clinical trial was carried out in the Department of Dermatology and... more
Objective To assess the efficacy of benzoyl peroxide and clindamycin combination therapy with benzoyl peroxide alone in the treatment of acne vulgaris. Methods A clinical trial was carried out in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The study duration was from July 2013 to December 2013. Total sixty patients of clinically diagnosed mild to moderate acne was enrolled and thirty of group A patients were treated by benzoyl peroxide alone and thirty of group B patients were treated by benzoyl peroxide and clindamycin combination therapy. Results At baseline mean number of comedones in group A and group B was 12.77±4.01 and 11.80±3.93, respectively ( p =0.350) and at final follow-up 4.17±4.02 and 3.47±4.00 ( p >0.05). At baseline mean number of papules in group A and group B was 17.30±10.29 and 18.57±13.88, respectively ( p =0.690) and at final follow-up 7.63±8.08 and 7.73±9.98 ( p >0.05). At baseline mean number...
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Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/ AIDS) is a global pandemic. According to Global HIV & AIDS statistics 2018, approximately 36.9 million people are living with HIV globally, 77.3 million... more
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/ AIDS) is a global pandemic. According to Global HIV & AIDS statistics 2018, approximately 36.9 million people are living with HIV globally, 77.3 million [59.9 million–100 million] people have become infected with HIV since the start of the epidemic, 35.4 million [25.0–49.9 million] people died from AIDS-related illnesses since the start of the epidemic and 940000 [670000–1.3 million] people died from AIDS-related illnesses in 2017. It weakens a person’s immune system by destroying important cells that fight disease and infection. Dermatologic diseases are common in the HIV-infected population. Skin disease can be uniquely associated with HIV disease and many of the cutaneous diseases are not unique to this group, but the presentation can be more severe and recalcitrant to treatment. The spectrum of skin conditions includes skin findings associated with primary HIV infection and a broad range of skin...
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Background: Pemphigus vulgaris is associated with high morbidity as well as significant mortality rate. Today the risk of death in pemphigus from the side effect of oral prednisolone is greater than risk of death from the disease itself.... more
Background: Pemphigus vulgaris is associated with high morbidity as well as significant mortality rate. Today the risk of death in pemphigus from the side effect of oral prednisolone is greater than risk of death from the disease itself. Objective: To observe the adverse effects of parenteral dexamethasone compared with oral prednisolone in the treatment of pemphigus vulgaris. Methods: An interventional study was carried out in the department of Dermatology and Venereology, Bangabandu Sheikh Mujib Medical University, Dhaka, Bangladesh. Total number of patients was thirty and among them fifteen patients were treated with parenteral dexamethasone (Group-A) and other fifteen were treated with oral prednisolone (Group-B). Results: The study showed statistically significant differences of skin lesion as well as mucosal lesion of pemphigus after 6 weeks of therapy between of two groups (P<0.05). The most common adverse effects were increased body weight(40%), increased appetite(40%),...
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Background: For better management of lichen planus a clinical trial of oral methotrexate is necessary in ow· country. Objective: The objective of this study is to evaluate efficacy and safety ofmethotrexate therapy in the treatment of... more
Background: For better management of lichen planus a clinical trial of oral methotrexate is necessary in ow· country. Objective: The objective of this study is to evaluate efficacy and safety ofmethotrexate therapy in the treatment of lichen planus.Methods: It was a prospective randomized controlled clinical trial conducted in the department of Dermatology and Venereology, BSMMU, Dhaka, from January 2009 to December 2010. Forty four patients of lichen planus were included in the study. Cases (group-A, n=23) were treated with methotrexate (10 mg) single morning dose and control (group-B, n=21) were treated with mini pulse betamethasone (5mg) single morning dose on 2 consecutive days during the period of 12 weeks. Results: Clinical parameters were measured by follow up clinical examination. Morphological lesion of lichen planus improved 95. 7% in group-A and only 28.6% improved in group-B. At the end of study 82.6% bad no complaints of itching in group-A and 100% had no complaints of ...
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Background: Vitiligo is a common dermatological disorder characterized by acquired, idiopathic, progressive, hypomelanosis of the skin and hair, with total absence of melanocytes microscopically. Objective: The study was conducted to find... more
Background: Vitiligo is a common dermatological disorder characterized by acquired, idiopathic, progressive, hypomelanosis of the skin and hair, with total absence of melanocytes microscopically. Objective: The study was conducted to find out the relationship between serum zinc level and clinical spectrum of vitiligo. Methods: A cross sectional study conducted in the departmenl of Dermatology and Venereology and department of Biochemistry, Bangabandbu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh and the period of study was from May 2010 to October 2011. Results: The mean difference of sernm zinc level in male and female of both groups were significant (p<0.05) but the mean serum zinc level was not significantly different (p>0.05) among various clinical types ofvitiligo. ln case oflocalized vitiligo mean serum zinc level was 755.3 ± 288.6, in case of acrofacial viriligo mean serum zinc level was 821.4 ± 259.6 and in case of generalized vitiligo mean sernm zinc le...
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Most of the patients of psoriasis have a chronic course withthe need for continuous control of disease activity. Patientswith moderate-to-severe disease generally requirephototherapy, photo-chamotherapy or systemic agents... more
Most of the patients of psoriasis have a chronic course withthe need for continuous control of disease activity. Patientswith moderate-to-severe disease generally requirephototherapy, photo-chamotherapy or systemic agents (e.g.cyclosporine, methotrexate, oral retinoids, fumaric acidesters) to control their disease adequately. In general thesetherapeutic modalities have proven to be highly effective inthe treatment of psoriasis. However, potentially serious toxicitycan limit their long term use. In this respect, hydroxyureacompares favourably with methotrexate which has a potentialfor producing irreversible hepatic damage and cyclosporineA with its potential for dose-related nephrotoxicity.Hydroxyurea, a hydroxylated molecule of urea is commonlyused to treat chronic myelogeneous leukemia andpolycythemia vera. Recent studies suggest it as an alternativeto methotrexate in moderate-to-severe psoriasis. DOI: http://dx.doi.org/10.3329/jbcps.v29i4.11330 J Bangladesh Coll Phys Surg 2011...
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Lipoid proteinosis is a rare autosomal recessive disorder, characterized histologically by infiltration of periodic acid Schiff-positive hyaline material into the skin, upper aerodigestive tract, and internal organs. Classical clinical... more
Lipoid proteinosis is a rare autosomal recessive disorder, characterized histologically by infiltration of periodic acid Schiff-positive hyaline material into the skin, upper aerodigestive tract, and internal organs. Classical clinical features include skin scarring, beaded eyelid papules, and laryngeal infiltration leading to hoarseness. Moreover, the infiltrates in the tongue and its frenulum limit lingual movements and cause speech difficulties. Usually, the hoarse voice is present at birth or in early infancy, as the first manifestation. In more severe cases, diffuse infiltration of the pharynx and larynx might cause respiratory distress, at times requiring tracheostomy. The disorder has recently been shown to result from loss-of-function mutations in the extracellular matrix protein 1 gene on chromosome 1q21. The function of the protein extracellular matrix protein 1 gene is still unclear, although an important role in skin physiology and homeostasis has been hypothesized. In t...
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Melasma is characterized by brown patches, typically on malar prominences and forehead. The pigmented patches are usually affect darker complexioned individual especially Asian. So it is a great problem in our country. A clinical trial... more
Melasma is characterized by brown patches, typically on malar prominences and forehead. The pigmented patches are usually affect darker complexioned individual especially Asian. So it is a great problem in our country. A clinical trial was conducted to find out the effect of the combination of 20% azelaic acid cream with 0.05% tretinoin cream in the treatment of melasma. Thirty clinically diagnosed cases of melasma attending the outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, were enrolled Majority of !he study subjects (43%) were between 26 to 30 years and most of them (73.3%) were female. Regarding occupation 56.7% were housewife. Out of the study subjects 70% were married and 86.7% were of middle class. Around 66.7% cases had positive family history of melasma and maximum 93.3% patient had no history of systemic drug and the maxim11m 73.3% patient had no history of use of cosmetics. It was observed that highest (93...
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Background: Seborrheic dermatitis is a common papulosquamous dermatosis and occurring in 2% to 5% of the population. The prevalence of seborrheic dermatitis among HIV-positive and AIDS patients between 34% and 83%. The ... more
Background: Seborrheic dermatitis is a common papulosquamous dermatosis and occurring in 2% to 5% of the population. The prevalence of seborrheic dermatitis among HIV-positive and AIDS patients between 34% and 83%. The anti-inflammatory activity of oral itraconazole and efficacy on Malessezia suggests that itraconazole capsule will be the first oral treatment option in future in seborrheic dermatitis. Unfortunately there is no data base study with the efficacy of oral itraconazole for the treatment of seborrheic dermatitis over Bangladeshi people.Objectives: To evaluate the efficacy of itraconazole in the treatment of Seborrheic dermatitis.Methods: This was an interventional type of study and total thirty seven patients of seborrheic dermatitis from department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU) was enrolled. The study was carried out for a period of two years from January 2008 to December 2009 and purposive type non-pro...
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Background & Methodology: It was an opened clinical trial. The study was carried out from March 2009 to February 2011, in the outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU)... more
Background & Methodology: It was an opened clinical trial. The study was carried out from March 2009 to February 2011, in the outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka, Bangladesh to evaluate the efficacy and side effects of the combination therapy of hydroquinone(HQ), kojic acid(KA) and glycolic acid(GA) for the treatment of melasma. Patients suffering from melasma were selected as study population. Within the period of data collection, thirty patients of melasma were assigned purposively. The efficacy was evaluated using Melasma Area and Severity Index (MASI) Score. The severity of melasma of each of the four regions (forehead, right malar region, left malar region and chin) are assessed based on three variables, percentage of the total area involved (A), darkness (D) and homogenicity (H).Results:The study showed that majority (30%) of the cases were between 20 to 25 years, majority (77%) of patients were f...
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A clinical trial was carried out in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka to evaluate the efficacy of Mometasone Furoate 0.1% cream in atopic dermatitis. Forty patients... more
A clinical trial was carried out in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka to evaluate the efficacy of Mometasone Furoate 0.1% cream in atopic dermatitis. Forty patients of atopic dermatitis were selected and randomized into two groups. In Group I, study patients were applied Mometasone Furoate 0.1% cream to the affected skin and in Group II, control patients were allowed to apply white vaseline to the affected skin. SCORAD index was assessed fortnightly at 2nd and 3rdvisit and final SCORAD index were calculated at the end of 4 week (3rd visit). In the study, at base line SCORAD index in case group was 49.76 ± 17.25 and in control group was 55.25 ± 13.94 (p>0.05). At 2nd visit that is at the end of 2 (two) weeks of medication SCORAD in case group was 27.39 ± 11.16 and in control group was 50.05 ± 14.69 (p=0.001) and at 3rd visit that is at the end of 4 (four) weeks of medication in case group SCORAD was 12.08 ± 6....
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Leprosy (Hansens disease) is a chronic granulomatous infectious disease that primarily affects the peripheral nerves, skin, upper respiratory tract mucosa, eyes and certain other tissues. It is diagnosable and curable if recognized early... more
Leprosy (Hansens disease) is a chronic granulomatous infectious disease that primarily affects the peripheral nerves, skin, upper respiratory tract mucosa, eyes and certain other tissues. It is diagnosable and curable if recognized early and treated adequately. A twenty nine-year-old male from Jessore, Bangladesh reported in Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh with the complaints of multiple erythematous, large, raised and circumscribed lesions with loss of sensations on different parts of the body, especially distal portions of all four limbs for last eight months. Subsequently he developed ulcers on the anesthetic fingers due to smoking and few ulcerative lesions on both feet. Skin examination revealed multiple erythematous, large nodular lesions on both sides of the cheek and forehead, multiple erythematous, indurated, large plaques with raised margin and central clearing on the trunk, waist and all four limbs, few satellite lesions around the large pl...
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The causes of polyneuropathy are many and it is important to identify them, as some of them, especially the inflammatory types are treatable. To explore the different etiological factors of polyneuropathy, this cross sectional study was... more
The causes of polyneuropathy are many and it is important to identify them, as some of them, especially the inflammatory types are treatable. To explore the different etiological factors of polyneuropathy, this cross sectional study was carried out in the department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka. Data were collected by taking medical history and clinical examination and subsequent laboratory investigations. A total of 60 subjects were included in this study and mean age of the entire patient was 42.25 year. Out of all respondents, 83.3% had muscle weakness, similar number had problems with object handling, 66.3% had muscle cramp, 63.3% had impaired standing or gait, 55.0% had distal paraesthesia, 41.7% had burning feet, 8.3% had restless legs and 5.0% had stiffness. Out of all patients of polyneuropathy, 33.3% had diabetic neuropathy, 11.7% had Guillain-Barré syndrome, 10.0% had chronic inflammatory demyelinating polyneuropathy, si...