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Publication Date: 2014
Publication Name: Radiotherapy and Oncology
Research Interests:
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Publication Date: 2014
Publication Name: PLoS ONE
Research Interests:
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Swallowing-sparing intensity-modulated radiotherapy for head and neck cancer patients: Treatment planning optimization and clinical introductionmore
by Kim Wopken and Johannes Langendijk
Publication Date: 2013
Research Interests: Adolescent, Prospective studies, Humans, Female, Male, and 5 moreAged, Middle Aged, Adult, Parotid Gland, and Cohort Studies
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PO-0715 VARIABILITY OF NTCP PREDICTION OF SWALLOWING ORGANS AT RISK, DUE TO VARIATION IN DELINEATION GUIDELINESmore
by Kim Wopken and Johannes Langendijk
Publication Date: 2012
Publication Name: Radiotherapy and Oncology
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Publication Date: 2008
Publication Name: Cereal Chemistry
Research Interests:
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To determine if acute symptoms during definitive radiotherapy (RT) or chemoradiation (CHRT) are prognostic factors for late dysphagia in head and neck cancer (HNC). This prospective cohort study consisted of 260 HNC patients who received... more
To determine if acute symptoms during definitive radiotherapy (RT) or chemoradiation (CHRT) are prognostic factors for late dysphagia in head and neck cancer (HNC). This prospective cohort study consisted of 260 HNC patients who received definitive RT or CHRT. The primary endpoint was grade 2-4 swallowing dysfunction at 6months after completing RT (SWALM6). During treatment, acute symptoms, including oral mucositis, xerostomia and dysphagia, were scored, and the scores were accumulated weekly and entered into an existing reference model for SWALM6 that consisted of dose-volume variables only. Both acute xerostomia and dysphagia were strong prognostic factors for SWALM6. When acute scores were added as variables to the reference model, model performance increased as the course of treatment progressed: the AUC rose from 0.78 at the baseline to 0.85 in week 6. New models built for weeks 3-6 were significantly better able to identify patients with and without late dysphagia. Acute xeros...