Papers by Dirk Van Gestel
Physica Medica, 2019
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Radiation Oncology, Jun 28, 2023
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Physics and Imaging in Radiation Oncology, Jul 1, 2022
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World Journal of Urology, Mar 1, 2019
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Radiotherapy and Oncology, May 1, 2023
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Frontiers in Oncology, Feb 19, 2021
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Technical Innovations & Patient Support in Radiation Oncology, Jun 1, 2022
Highlights • Radiation Therapists specialised in image-guided radiation therapy (RTT spIGRT) expe... more Highlights • Radiation Therapists specialised in image-guided radiation therapy (RTT spIGRT) experience their role positiveltly.• The RTT spIGRT role is perceived to have a positive influence on radiotherapy treatment delivery.• A legal framework to provide formal RTT training and continuous education in order to increase radiotherapy treatment quality is of utmost importance.
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Cancer Radiotherapie, Apr 1, 2020
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Precision Cancer Medicine
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Dysphagia
Cough efficacy is considered a reliable predictor of the aspiration risk in head and neck cancer ... more Cough efficacy is considered a reliable predictor of the aspiration risk in head and neck cancer patients with radiation-associated dysphagia. Currently, coughing is assessed perceptually or aerodynamically. The goal of our research is to develop methods of acoustic cough analysis. In this study, we examined in a healthy population the acoustical differences between three protective maneuvers: voluntary cough, voluntary throat clearing, and induced reflexive cough. Forty healthy participants were included in this study. Voluntary cough, voluntary throat clearing, and reflexive cough samples were recorded and analyzed acoustically. Temporal acoustic features were the following: the slope and curvature of the amplitude contour, as well as the average, slope, and curvature of the sample entropy and kurtosis contours of the recorded signal. Spectral features were the relative energy in the frequency bands (0–400 Hz, 400–800 Hz, 800–1600 Hz, 1600 Hz-3200 Hz, > 3200 Hz) as well as the ...
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Radiotherapy and Oncology, 2020
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Radiotherapy, by its mechanism, has always been suspected to be contra-indicated in patients with... more Radiotherapy, by its mechanism, has always been suspected to be contra-indicated in patients with xeroderma pigmentosum, depriving them of this very effective modality in the treatment of their cancers. As these suspicions have still not been confirmed, the place of radiotherapy should be reconsidered, while applying precautionary principles.
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Radiotherapy and Oncology, 2020
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Radiotherapy and Oncology, 2021
BACKGROUNDAND PURPOSE: to evaluate dosimetric differences in unintended dose to the lower axilla ... more BACKGROUNDAND PURPOSE: to evaluate dosimetric differences in unintended dose to the lower axilla between 3D-standard (3DCRT), tangential beam forward intensity modulated radiotherapy (F-IMRT) and volumetric modulated arc therapy (VMAT). The objective is to evaluate whether results of clinical trials, such as the ACOSOG-Z011 trial, that evaluated omission of axillary clearance can be extrapolated towards more conformal techniques like VMAT. MATERIALS AND METHODS twenty-five consecutive patients treated with whole breast radiotherapy alone (WBRT) using a F-IMRT technique were identified. Three additional plans were created for every patient: one plan using a single 270° arc (VMAT 1x270°), another using two small ≤90° opposing arcs (VMAT 2x <90°) and thirdly a 3DCRT plan without F-IMRT. Axillary levels I-II were contoured after the treatment plans were made. RESULTS the volume of the axilla level I that was covered by the 50% isodose (V50%) was significantly higher for VMAT 2x <90° (71.3cm3, 84% of structure volume, p<0.001) and VMAT 1x270° (68.8 cm3, 81%, p<0.01) compared to 3DCRT (60.3cm3, 71%) and F-IMRT (60.8cm3, 72%). The V50% to the axilla level II, however, was low for all techniques: 12.3cm3 (12%); 8.9cm3 (9%); 4.3cm3 (4%); 4.4cm3 (4%) for VMAT 2x <90°, VMAT 1x270°, 3DCRT, F-IMRT, respectively. For the higher doses (V90% and above), no clinically relevant differences were seen between the different modalities. CONCLUSION WBRT treatments with VMAT do not lead to a significant reduction of the unintended axillary dose in comparison with a tangential beam setup. Hence, concerning tumor control, VMAT can be applied to clinical situations similar to the Z0011 trial. The intermediate axillary dose is higher with VMAT, but the clinical consequence of this difference on toxicity is unknown.
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Radiotherapy and Oncology, 2021
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Radiotherapy and Oncology, 2021
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Scholars Journal of Medical Case Reports, 2020
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Physica Medica, 2020
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Cancers, 2019
Radiotherapy (RT) in patients with melanoma historically showed suboptimal results, because the d... more Radiotherapy (RT) in patients with melanoma historically showed suboptimal results, because the disease is often radioresistant due to various mechanisms such as scavenging free radicals by thiols, pigmentary machinery, or enhanced DNA repair. However, radiotherapy has been utilized as adjuvant therapy after the complete excision of primary melanoma and lymph nodes to reduce the rate of nodal recurrences in high-risk patients. The resistance of melanoma cells to radiotherapy may also be in relation with the constitutive activation of the MAPK pathway and/or with the inactivation of p53 observed in about 90% of melanomas. In this study, we aimed to assess the potential benefit of adding RT to BRAF-mutated melanoma cells under a combined p53 reactivation and MAPK inhibition in vitro and in a preclinical animal model. We found that the combination of BRAF inhibition (vemurafenib, which completely shuts down the MAPK pathway), together with p53 reactivation (PRIMA-1Met) significantly en...
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Radiotherapy and Oncology, 2019
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Papers by Dirk Van Gestel