IntroductionKnowledge of normal radiographic appearance is essential to avoid misinterpretation of radiographs. This study aimed to assess the computed tomographic (CT) appearance of the plantar surface of the proximal metatarsus and... more
IntroductionKnowledge of normal radiographic appearance is essential to avoid misinterpretation of radiographs. This study aimed to assess the computed tomographic (CT) appearance of the plantar surface of the proximal metatarsus and evaluate the influence of the radiographic angle on the trabecular/cortical interface of the proximal plantar metatarsal cortex on lateromedial and slightly oblique radiographs.MethodsEight hindlimbs were collected from six horses with no known history of lameness and euthanized for reasons unrelated to the study. Limbs underwent computed tomographic (CT) and radiographic examination (dorsoplantar, lateromedial, and slightly oblique radiographic views obtained by angling the beam dorsally and plantarly from the plane used for the lateromedial projection). Standing magnetic resonance (MR) imaging and computed tomography (CT) were used to confirm normalcy. Images were compared side-by-side by two experienced readers.ResultsLimbs were normal at MR imaging....
Hydrotherapy has been utilized in horse rehabilitation programs for over four decades. However, a comprehensive description of the swimming cycle of horses is still lacking. One of the challenges in studying this motion is 3D underwater... more
Hydrotherapy has been utilized in horse rehabilitation programs for over four decades. However, a comprehensive description of the swimming cycle of horses is still lacking. One of the challenges in studying this motion is 3D underwater motion capture, which holds potential not only for understanding equine locomotion but also for enhancing human swimming performance. In this study, a marker-based system that combines underwater cameras and markers drawn on horses is developed. This system enables the reconstruction of the 3D motion of the front and hind limbs of six horses throughout an entire swimming cycle, with a total of twelve recordings. The procedures for pre- and post-processing the videos are described in detail, along with an assessment of the estimated error. This study estimates the reconstruction error on a checkerboard and computes an estimated error of less than 10 mm for segments of tens of centimeters and less than 1 degree for angles of tens of degrees. This study...
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L'objectif de cette these etait d'etudier, dans les conditions de l'examen clinique des boiteries, les mouvements de chevaux atteints de lesions de l'appareil locomoteur. La premiere partie de cette these comprend 4... more
L'objectif de cette these etait d'etudier, dans les conditions de l'examen clinique des boiteries, les mouvements de chevaux atteints de lesions de l'appareil locomoteur. La premiere partie de cette these comprend 4 articles consacres a l'evaluation de la symetrie locomotrice. Dans le premier article, les effets des asymetries de placement des marqueurs entre les 2 cotes du cheval sur les variables cinematiques sont determines. Dans le deuxieme et le troisieme article, la symetrie des mouvements des membres est etudiee par une methode d'inter-correlation. Dans le quatrieme, la symetrie des mouvements du tronc est etudiee a l'aide des series de fourier. Dans ces articles, plusieurs indices permettant de quantifier le degre de boiterie d'un cheval, d'identifier automatiquement le membre boiteux et de caracteriser la nature des mouvements compensateurs du tronc ont ete definis. La seconde partie de ce travail concerne l'etude des mouvements de flexion-extension du dos du cheval. Cette partie comprend egalement 4 articles. Le premier article presente, en terme de decours angulaires, les mouvements de flexion-extension des 3 principales regions du dos du cheval (parties thoracique, thoraco-lombaire et lombo-sacree) dans une population de chevaux sains. Le deuxieme article decrit et evalue une methode permettant de mesurer in vivo, au niveau de chaque etage vertebral, les deplacements generes par les mouvements de flexion-extension thoraco-lombaire. Le troisieme presente les resultats de l'exploitation de cette methode sur une population de chevaux sains, alors que le quatrieme article presente les resultats obtenus dans une population de chevaux atteints de troubles locomoteurs spontanes.
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L'objectif de cette these etait d'etudier, dans les conditions de l'examen clinique des boiteries, les mouvements de chevaux atteints de lesions de l'appareil locomoteur. La premiere partie de cette these comprend 4... more
L'objectif de cette these etait d'etudier, dans les conditions de l'examen clinique des boiteries, les mouvements de chevaux atteints de lesions de l'appareil locomoteur. La premiere partie de cette these comprend 4 articles consacres a l'evaluation de la symetrie locomotrice. Dans le premier article, les effets des asymetries de placement des marqueurs entre les 2 cotes du cheval sur les variables cinematiques sont determines. Dans le deuxieme et le troisieme article, la symetrie des mouvements des membres est etudiee par une methode d'inter-correlation. Dans le quatrieme, la symetrie des mouvements du tronc est etudiee a l'aide des series de fourier. Dans ces articles, plusieurs indices permettant de quantifier le degre de boiterie d'un cheval, d'identifier automatiquement le membre boiteux et de caracteriser la nature des mouvements compensateurs du tronc ont ete definis. La seconde partie de ce travail concerne l'etude des mouvements de fl...
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ABSTRACT Introduction Matrix therapy was introduced as a new branch in regenerative medicine led by the concept that reorganisation of the extracellular matrix (ECM) and restoration of the cellular micro-environment can trigger a... more
ABSTRACT Introduction Matrix therapy was introduced as a new branch in regenerative medicine led by the concept that reorganisation of the extracellular matrix (ECM) and restoration of the cellular micro-environment can trigger a regeneration process. Robust demonstration were provided in many publications [1] describing the efficacy of ReGeneraTing Agents (RGTA®) in improving speed and quality of healing of various injured tissues (skin, cornea, muscle….) both in preclinical models and in clinic without any report of toxicity. RGTA® are nano-biodegradable polymers engineered to mimic and replace heparan sulfates both as a storage and protector site for growth factors as well as a scaffold element in the reconstruction and organisation of the ECM of injured tissues. Horse tendonitis represents a big challenge for trainers and veterinarians and currently, no treatment has clearly proven its effectiveness in improving tendon healing. We now present several studies demonstrating that one dedicated RGTA® named EQUITEND® presents an efficient alternative for the treatment of tendonitis and recovery of horses’ performances. Methods Three studies were conducted by the CIRALE’s team. EQUITEND® has been tested in tendon healing after a single intra-lesional injection and under ultrasound guidance. The first one is a retrospective study included 16 French trotters with Superficial Digital Flexor Tendinopathy (SDFT) treated once with EQUITEND® and compared with a matching group. The second one is an experimental efficacy study on 12 experimental French Trotters after surgical induced SDFT [2]. The last one is a controlled randomised clinical trial conducted on 22 French Trotters (FT) race horses with spontaneous cases of tendonitis. Results The retrospective study demonstrates that horses treated with EQUITEND® went back in racing 2.4 months earlier and earned more in races than control group (74%, versus 15% in the control group). In the experimental efficacy study, improvement was suspected during the follow up of healing by echography but confirmed and quantified by measuring and comparing the mechanical resistance to rupture on isolated tendons at 3 months after injury. Taking into account of the horses’ age in the statistical analysis, (as it is a determining factor in the SDFT incidence), results revealed a significant positive effect of the EQUITEND® treatment on maximal force (p = 0.0038) (Figure 1) and on the stress at maximal force (p = 0.058). Finally, clinical trial has shown that EQUITEND® treated horses went back to racing in a shorter time, their performance as earning per race (compared to earnings per race before injury) was higher and they tend to have fewer tendonitis recurrence than placebo horses. Discussion All these studies demonstrated a good tolerance of EQUITEND®, a quick improvement of healing assessed by the ultrasound examination and a better recovery of horse’s performances in EQUITEND® treated group. The experimental study detailed the improvement of quality of healing evaluated by mechanical resistance properties of tendon to rupture, significantly higher for EQUITEND® horses. We conclude that EQUITEND® offers a real advantage upon existing therapies for tendonitis in racing horses. References 1 Johan van Neck, Bastiaan Tuk, Denis Barritault and Miao Tong Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview chapter 4 in Tissue Regeneration – From Basic Biology to Clinical Application ISBN 978–953-51–0387-5, edited by Jamie Davies 2 Schramme et al. Vet Comp Orthop Traumatol. 2010;23(4):231–9
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Research Interests: Clinical Trial, Biology, Cell Cycle, Cell Biology, Adipose tissue, and 15 moreCell Differentiation, Female, Animals, Bone marrow, Adipogenesis, Biochemical, Alkaline phosphatase, Anthraquinones, Adipocytes, Chondrocytes, Chondrogenesis, Cell Proliferation, Adult Stem Cell, Biochemistry and cell biology, and Azo compounds
Les amyloïdoses sont un groupe de maladies dont la caractéristique commune est le dépôt d’une substance amyloïde dans le milieu extracellulaire. L’amyloïdose est le plus souvent de type AA ou AL selon le type de protéine à l’origine du... more
Les amyloïdoses sont un groupe de maladies dont la caractéristique commune est le dépôt d’une substance amyloïde dans le milieu extracellulaire. L’amyloïdose est le plus souvent de type AA ou AL selon le type de protéine à l’origine du dépôt (respectivement la protéine SAA ou les chaînes légères des immunoglobulines). On distingue des formes généralisées et localisées d’amyloïdose en fonction de la distribution de la substance dans les tissus ou organes. Les formes généralisées, les plus courantes chez le cheval, sont les amyloïdoses de type AA dont l’évolution est secondaire à un processus inflammatoire chronique. Les formes localisées chez le cheval sont quant à elles plus souvent de type AL. Nous présentons ici un cas original d’amyloïdose généralisée, probablement de type AA, diagnostiqué à l’autopsie, secondaire à un processus infectieux chronique sous-cutané et osseux.
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Research Interests: Ultrasound and Collateral
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La scintigraphie osseuse est une technique interessante dans le diagnostic des pathologies locomotrices chez le cheval. Une dosimetrie et des mesures de contamination ont ete realisees pour determiner l'exposition aux rayonnements... more
La scintigraphie osseuse est une technique interessante dans le diagnostic des pathologies locomotrices chez le cheval. Une dosimetrie et des mesures de contamination ont ete realisees pour determiner l'exposition aux rayonnements ionisants pendant une scintigraphie osseuse. Des debits d'equivalents de dose ont ete detectes selon les differentes situations rencontrees lors de l'examen d'un cheval adulte de 500 kg (injection de 5,027 GBq de diphosphonate marque au technetium). Dans le but de reduire l'exposition du personnel, il est recommande de realiser les examens complementaires d'imagerie (radiographie, echographie) 24 heures apres l'injection du radiopharmaceutique, et de curer les boxes 4 jours apres cette injection.
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PROXIMAL palmar metacarpal pain is recognised as a major cause of forelimb lameness in athletic horses ([Dyson 2003][1]). The differential diagnosis is routinely based on clinical findings, perineural analgesia, and ultrasonographic,... more
PROXIMAL palmar metacarpal pain is recognised as a major cause of forelimb lameness in athletic horses ([Dyson 2003][1]). The differential diagnosis is routinely based on clinical findings, perineural analgesia, and ultrasonographic, radiographic and nuclear scintigraphic examinations ([Dyson 2003][
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