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Latest articles

    1. Cell Biology
    2. Medicine

    PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

    Pengbo Chen, Bo Li ... Xinfeng Zheng
    The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal cells was characterized in vitro.
    1. Medicine

    Loss of CTRP10 results in female obesity with preserved metabolic health

    Fangluo Chen, Dylan C Sarver ... G William Wong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine
    2. Immunology and Inflammation

    Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

    Haiyi Fei, Xiaowen Lu ... Lingling Jiang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine

    Three components of glucose dynamics – value, variability, and autocorrelation – are independently associated with coronary plaque vulnerability

    Hikaru Sugimoto, Ken-ichi Hironaka ... Shinya Kuroda
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine
    2. Neuroscience

    CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis

    Ayni Sharif, Matthew S Jeffers ... Manoj M Lalu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Medicine

    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Medicine

    Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

    Marketa Jirouskova, Karel Harant ... Martin Gregor
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine

    Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

    Feilin Cao, Zhaosheng Ma ... Shifen Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Medicine

    Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Imposing Calorie Restriction: A Randomized Controlled Pilot Study

    Isabell Wilming, Jana Tuschewski ... Dominic Landgraf
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Medicine

    Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

    Ole Bæk, Tik Muk ... Duc Ninh Nguyen
    Reduced parenteral glucose during neonatal infection redirects hepatic metabolism to oxidative phosphorylation and gluconeogenesis, dampens systemic proinflammatory responses, and significantly enhances survival in preterm newborns.
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Highlights

    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    Explore the latest COVID-19 research

    Edited by Diane M Harper et al.
    1. Medicine

    Meet our new Senior Editors in Medicine

    1. Medicine
    2. Epidemiology and Global Health
    virus

    We’ve extended the deadline for our call for papers on the impact of COVID-19 on cancer

Senior editors

  1. Olujimi A Ajijola
    University of California, Los Angeles, United States
  2. Pramod Mistry
    Yale University School of Medicine, United States
  3. Ma-Li Wong
    State University of New York Upstate Medical University, United States
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