Diffusion and Displacement Encoded MRI Dataset to Estimate In Vivo Cardiomyocyte Strain

## Supplemental MRI Data for in vivo estimation of cardiomyocyte strain ##

The contents of this dataset includes the necessary DENSE MRI and cDTI data to 

compute in vivo cardiomyocyte strain at one mid-ventricular location. The 

following README file will break down the contents of this supplemental dataset.

A detailed description of the methods used to compute cardiomyocyte strain from

the attached data can be found in the following work:

> Verzhbinsky, I.A., Perotti, L.E., Moulin K., Cork, T.E., Loecher, M., 

> Ennis, D.B. (2019). Estimating Aggregate Cardiomyocyte Strain Using In Vivo 

> Diffusion and Displacement Encoded MRI. 

### DENSE folder

#### Dicom subfolder

The DENSE folder contains all DENSE MRI data in the 'Dicom' subfolder. Data is 

divided into magnitude, x phase, y phase, and z phase dicoms for 2 DENSE MRI

slices located 4 mm above and below the location of cDTI.

#### Processed subfolder

The 'Processed' subfolder contains the processed Langrangian displacements for 

each DENSE MRI slice in a MatLab file format. DENSE MRI displacement data was 

processed using the following open-source DENSE processing tool:

> https://github.com/denseanalysis/denseanalysis

### cDTI folder

#### Dicom subfolder

Diffusion weighted dicom data acquired across the entire left ventricle is 

located in the Dicom subfolder. The data is organized into 1 b0 image followed

by 12 diffusion weighted images repeated 30 times. 

(1 b0 + 12 Diffusion) * 30 averages = 390 total images.  

The cDTI slice that is located between the 2 provided DENSE slices is number 6, 

with image number 1 beginning at the most apical slice.

### Processed subfoler

The processed subfolder contains a single MatLab file with the diffusion weighed

images and reconstructed diffusion tensors registered to the DENSE MRI data. 

'IMaffine' - a cDTI image matrix at slice 6 with the following dimensions:

[yres xres (b0 + 12 diffusion)]

'D' - the registered reconstructed diffusion tensors at slice 6 with the 

following dimensions:

[yres xres 3 3] 

At each cDTI voxel, all reconstructed diffusion tensors are represented as 

symmetric 3 by 3 matrices.