Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action
<p>The interaction of polyphenols with cellular signaling pathways involved in chronic disease. Flavonoid-induced activation and/or inhibition of MAP kinase and PI3 kinase signaling leads to the activation of transcription factors which drive gene expression. For example, activation of ERK/Akt and the downstream transcription factor CREB by flavonoids may promote changes in neuronal viability and synaptic plasticity, which ultimately influence neurodegenerative processes. Polyphenol-induced inhibition of the JNK, ASK1 and p38 pathways leads to inhibition of both apoptosis in neurons and a reduction of neuroinflammatory reactions in microglia (reduced iNOS expression and NO• release). Alternatively, their interaction with signaling may lead to direct activation of proteins such as eNOS, which controls nitric oxide release in the vasculature and thus influences CVD risk.</p> "> Figure 2
<p>Formation of Advanced Glycation Endproducts (AGEs) and the sites where flavonoids may inhibit their formation (*). These include monosaccharide autoxidation, glycation, glycoxidation, as well as AGE receptor binding, which results in the activation and release of inflammation mediators.</p> ">
Abstract
:1. Introduction
2. Polyphenols and Cancer
3. Polyphenols and Cardiovascular Disease
4. Polyphenols and Neurodegeneration
5. Summary
Acknowledgements
References
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Vauzour, D.; Rodriguez-Mateos, A.; Corona, G.; Oruna-Concha, M.J.; Spencer, J.P.E. Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action. Nutrients 2010, 2, 1106-1131. https://doi.org/10.3390/nu2111106
Vauzour D, Rodriguez-Mateos A, Corona G, Oruna-Concha MJ, Spencer JPE. Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action. Nutrients. 2010; 2(11):1106-1131. https://doi.org/10.3390/nu2111106
Chicago/Turabian StyleVauzour, David, Ana Rodriguez-Mateos, Giulia Corona, Maria Jose Oruna-Concha, and Jeremy P. E. Spencer. 2010. "Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action" Nutrients 2, no. 11: 1106-1131. https://doi.org/10.3390/nu2111106