Effect of Fucoidan Extracted from Mozuku on Experimental Cartilaginous Tissue Injury
<p>Average defect restoration scores. Data are expressed as the average ± standard deviation. * <span class="html-italic">p</span> < 0.05.</p> "> Figure 2
<p>Light microscopy of tissues from each group (HE stain; 40×). (<b>A</b>) C group; (<b>B</b>) F 8 group; (<b>C</b>) F 50 group; (<b>D</b>) F 146 group; (<b>E</b>) F 239 group; (<b>F</b>) F 330 group; (<b>G</b>) F 400 group; (<b>H</b>) F 1000 group. (a) cartilage layer; (b) superficial layer of cancellous bone; (c) deeper layer of cancellous bone. * joint cavity.</p> "> Figure 3
<p>Light microscopy of tissues from each group (Alcian blue stain; ×40). (<b>A</b>) C group; (<b>B</b>) F 8 group; (<b>C</b>) F 50 group; (<b>D</b>) F 146 group; (<b>E</b>) F 239 group; (<b>F</b>) F 330 group; (<b>G</b>) F 400 group; (<b>H</b>) F 1000 group.</p> "> Figure 4
<p>Light microscopy of tissues from each group (safranin O stain; 40×). (<b>A</b>) C group; (<b>B</b>) F 8 group; (<b>C</b>) F 50 group; (<b>D</b>) F 146 group; (<b>E</b>) F 239 group, (<b>F</b>) F 330 group; (<b>G</b>) F 400 group; (<b>H</b>) F 1000 group.</p> "> Figure 5
<p>Image analysis of Alcian blue-stained specimens. Data are expressed as the average ± standard deviation. *<span class="html-italic">p</span> < 0.05.</p> "> Figure 6
<p>Image analysis of safranin O-stained specimens. The data are expressed as the average ± standard deviation. * <span class="html-italic">p</span> < 0.05.</p> ">
Abstract
:1. Introduction
2. Results
2.1. General Condition
2.2. Changes in Muscle Weight
2.3. Macroscopic Findings
2.4. Histological Findings
2.5. Image Analysis for Safranin O- and Alcian Blue-Stained Specimens
3. Discussion
4. Experimental Section
4.1. Preparation of Fucoidan
4.2. Animals
4.3. Fucoidans
4.4. Preparation of the Model of Articular Cartilage Injury
4.5. Postmortem Examination
4.6. Evaluation of Healing at Injured Sites
4.7. Histological Examination
4.8. Statistical Analysis
5. Conclusion
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Osaki, T.; Kitahara, K.; Okamoto, Y.; Imagawa, T.; Tsuka, T.; Miki, Y.; Kawamoto, H.; Saimoto, H.; Minami, S. Effect of Fucoidan Extracted from Mozuku on Experimental Cartilaginous Tissue Injury. Mar. Drugs 2012, 10, 2560-2570. https://doi.org/10.3390/md10112560
Osaki T, Kitahara K, Okamoto Y, Imagawa T, Tsuka T, Miki Y, Kawamoto H, Saimoto H, Minami S. Effect of Fucoidan Extracted from Mozuku on Experimental Cartilaginous Tissue Injury. Marine Drugs. 2012; 10(11):2560-2570. https://doi.org/10.3390/md10112560
Chicago/Turabian StyleOsaki, Tomohiro, Koudai Kitahara, Yoshiharu Okamoto, Tomohiro Imagawa, Takeshi Tsuka, Yasunari Miki, Hitoshi Kawamoto, Hiroyuki Saimoto, and Saburo Minami. 2012. "Effect of Fucoidan Extracted from Mozuku on Experimental Cartilaginous Tissue Injury" Marine Drugs 10, no. 11: 2560-2570. https://doi.org/10.3390/md10112560