ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics
Fig 8
Podocyte-specific ARF6 null mice have aggravated proteinuria following nephrotoxic serum nephritis glomerular injury.
A. Urine albumin to creatinine ratio (UACR) was determined for sheep serum or nephrotoxic serum (NTS) treated WT and podocyte-specific ARF6 null mice (mean ± SEM). Results are representative of 10–15 mice per group. B. Day 3 glomerular ultrastructure was assessed by scanning electron microscope. Magnification x3000. Scale bar 5 μm. C. Indirect immunofluorescence of mouse kidney tissue sections stained with anti-WT1 (green) and anti-nephrin (red). Magnification x63. Scale bar 20 μm. D. Podocyte number per glomerular volume (μm3) in all treatment groups.